Results 41 to 50 of about 8,679 (178)

Piecing together nonribosomal peptide synthesis

Current Opinion in Structural Biology, 2018
Nonribosomal peptide synthetases (NRPSs) produce peptide products with wide-ranging biological activities. NRPSs are macromolecular machines with modular assembly-line logic, a complex catalytic cycle, moving parts and multiple active sites. They are organized into repeating sets of domains, called modules.
Reimer, Janice M., Haque, Asfarul S., Tarry, Michael J., Schmeing, T. Martin   +3 more
openaire   +3 more sources

Prediction of monomer isomery in Florine: a workflow dedicated to nonribosomal peptide discovery. [PDF]

PLoS ONE, 2014
Nonribosomal peptides represent a large variety of natural active compounds produced by microorganisms. Due to their specific biosynthesis pathway through large assembly lines called NonRibosomal Peptide Synthetases (NRPSs), they often display complex ...
Thibault Caradec, Maude Pupin, Aurélien Vanvlassenbroeck, Marie-Dominique Devignes, Malika Smaïl-Tabbone, Philippe Jacques, Valérie Leclère   +6 more
doaj   +1 more source

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Metabolites, 2023
Three novel lipopeptides, PM130391 (1), PM130392 (2), and PM140293 (3) were obtained from cultures of Streptomyces tuirus PHM034 isolated from a marine sediment.
Ana Ceniceros, Librada Cañedo, Carmen Méndez, Carlos Olano, Carmen Schleissner, Carmen Cuevas, Fernando de la Calle, José A. Salas   +7 more
doaj   +1 more source

Dissecting and Exploiting Nonribosomal Peptide Synthetases

Acta Biochimica et Biophysica Sinica, 2004
A large number of therapeutically useful cyclic and linear peptides of bacteria or fungal origin are synthesized via a template-directed, nucleic-acid-independent nonribosomal mechanism. This process is carried out by mega-enzymes called nonribosomal peptide synthetases (NRPSs).
Qing-Tao, Shen, Xiu-Lan, Chen, Cai-Yun, Sun, Yu-Zhong, Zhang   +3 more
openaire   +2 more sources

Sfp-type PPTase inactivation promotes bacterial biofilm formation and ability to enhance wheat drought tolerance

Frontiers in Microbiology, 2015
Paenibacillus polymyxa is a common soil bacterium with broad range of practical applications. An important group of secondary metabolites in P. polymyxa are nonribosomal peptide and polyketide derived metabolites (NRP/PK).
Salme eTimmusk
doaj   +1 more source

Antibacterial Property of a Coral-Associated Bacterium Pseudoalteromonas luteoviolacea Against Shrimp Pathogenic Vibrio harveyi (In Vitro Study)

Hayati Journal of Biosciences, 2005
A coral-associated bacterium was successfully screened for secondary metabolites production based on PCR amplification of the nonribosomal peptide synthetase gene and was identified as closely related to Pseudoalteromonas luteoviolacea based on its 16S ...
OCKY KARNA RADJASA, TORBEN MARTENS, HANS-PETER GROSSART, AGUS SABDONO, MEINHARD SIMON, TONNY BACHTIAR   +5 more
doaj   +3 more sources

Norine: update of the nonribosomal peptide resource.

Nucleic acids research, 2019
Norine, the unique resource dedicated to nonribosomal peptides (NRPs), is now updated with a new pipeline to automate massive sourcing and enhance annotation. External databases are mined to extract NRPs that are not yet in Norine. To maintain a high data quality, successive filters are applied to automatically validate the NRP annotations and only ...
Flissi, Areski, Ricart, Emma, Campart, Clémentine, Chevalier, Mickael, Dufresne, Yoann, Michalik, Juraj, Jacques, Philippe, Flahaut, Christophe, Lisacek, Frederique, Leclère, Valérie, Pupin, Maude   +10 more
openaire   +5 more sources

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis

Nature Communications
Polyketides and nonribosomal peptides are important natural product classes with wide-ranging medical and agricultural applications. The analogous enzymatic logic employed by bacterial modular polyketide synthases (PKSs) and nonribosomal peptide ...
Munro Passmore, Xinyun Jian, Xinyi Zhao, Emmanuel L. C. de los Santos, Douglas M. Roberts, Józef R. Lewandowski, Matthew Jenner, Lona M. Alkhalaf, Gregory L. Challis   +8 more
doaj   +1 more source

The Nonribosomal Peptide Valinomycin: From Discovery to Bioactivity and Biosynthesis

Microorganisms, 2021
Valinomycin is a nonribosomal peptide that was discovered from Streptomyces in 1955. Over the past more than six decades, it has received continuous attention due to its special chemical structure and broad biological activities.
Shuhui Huang, Yushi Liu, Wan-Qiu Liu, Peter Neubauer, Jian Li   +4 more
doaj   +1 more source