Results 21 to 30 of about 8,679 (178)

A non-canonical NRPS is involved in the synthesis of fungisporin and related hydrophobic cyclic tetrapeptides in Penicillium chrysogenum. [PDF]

PLoS ONE, 2014
The filamentous fungus Penicillium chrysogenum harbors an astonishing variety of nonribosomal peptide synthetase genes, which encode proteins known to produce complex bioactive metabolites from simple building blocks. Here we report a novel non-canonical
Hazrat Ali, Marco I Ries, Peter P Lankhorst, Rob A M van der Hoeven, Olaf L Schouten, Marek Noga, Thomas Hankemeier, Noël N M E van Peij, Roel A L Bovenberg, Rob J Vreeken, Arnold J M Driessen   +10 more
doaj   +1 more source

NORINE: a database of nonribosomal peptides [PDF]

Nucleic Acids Research, 2007
Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows peptide production. It is performed by huge protein complexes called nonribosomal peptide synthetases (NRPSs).
Caboche, Ségolène, Pupin, Maude, Leclère, Valérie, Fontaine, Arnaud, Jacques, Philippe, Kucherov, Gregory   +5 more
openaire   +4 more sources

Exploring the selectivity and engineering potential of an NRPS condensation domain involved in the biosynthesis of the thermophilic siderophore fuscachelin

Frontiers in Catalysis, 2023
In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides or depsipeptides.
Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Y. T. Candace Ho, Thierry Izoré, Thierry Izoré, Joe A. Kaczmarski, Joe A. Kaczmarski, Edward Marschall, Edward Marschall, Edward Marschall, Minuri S. Ratnayake, Minuri S. Ratnayake, Minuri S. Ratnayake, Julien Tailhades, Julien Tailhades, Julien Tailhades, David L. Steer, David L. Steer, Ralf B. Schittenhelm, Ralf B. Schittenhelm, Manuela Tosin, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Colin J. Jackson, Max J. Cryle, Max J. Cryle, Max J. Cryle   +28 more
doaj   +1 more source

Biosynthesis and engineering of the nonribosomal peptides with a C-terminal putrescine

Nature Communications, 2023
The broad bioactivities of nonribosomal peptides rely on increasing structural diversity. Genome mining of the Burkholderiales strain Schlegelella brevitalea DSM 7029 leads to the identification of a class of dodecapeptides, glidonins, that feature ...
Hanna Chen, Lin Zhong, Haibo Zhou, Xianping Bai, Tao Sun, Xingyan Wang, Yiming Zhao, Xiaoqi Ji, Qiang Tu, Youming Zhang, Xiaoying Bian   +10 more
doaj   +1 more source

Polyketide Synthase and Nonribosomal Peptide Synthetase Gene Clusters in Type Strains of the Genus Phytohabitans

Life, 2020
(1) Background: Phytohabitans is a recently established genus belonging to rare actinomycetes. It has been unclear if its members have the capacity to synthesize diverse secondary metabolites.
Hisayuki Komaki, Tomohiko Tamura
doaj   +1 more source

Classification and Secondary Metabolite-Biosynthetic Gene Clusters of Marine Streptomyces Strains Including a Lobophorin- and Divergolide-Producer

Hydrobiology, 2023
Two Streptomyces strains, named N11-26 and DC10-5, were isolated from deep-sea and non-photosynthetic stony coral, respectively. Strain N11-26 produces lobophorin C and divergolides, which are antimicrobial substances.
Hisayuki Komaki, Tomohiko Tamura, Yasuhiro Igarashi   +2 more
doaj   +1 more source

Beyond Toxin Transport: Novel Role of ABC Transporter for Enzymatic Machinery of Cereulide NRPS Assembly Line

mBio, 2020
Nonribosomal peptide synthetases (NRPSs) and polyketide synthetases (PKSs) play a pivotal role in the production of bioactive natural products, such as antibiotics and cytotoxins. Despite biomedical and pharmaceutical importance, the molecular mechanisms
A. Gacek-Matthews, Z. Chromiková, M. Sulyok, G. Lücking, I. Barák, M. Ehling-Schulz   +5 more
doaj   +1 more source

Profile of PKS and NRPS Gene Clusters in the Genome of Streptomyces cellostaticus NBRC 12849^T

Fermentation, 2023
Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Streptomyces. Streptomyces cellostaticus is a validly recognized species and the type strain produces cellostatin. However, little is known about whether it has
Hisayuki Komaki, Tomohiko Tamura
doaj   +1 more source

Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential

Frontiers in Pharmacology, 2017
Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc.
Shivankar Agrawal, Shivankar Agrawal, Debabrata Acharya, Alok Adholeya, Colin J. Barrow, Sunil K. Deshmukh   +5 more
doaj   +1 more source

Pentaminomycins C–E: Cyclic Pentapeptides as Autophagy Inducers from a Mealworm Beetle Gut Bacterium

Microorganisms, 2020
Pentaminomycins C–E (1–3) were isolated from the culture of the Streptomyces sp. GG23 strain from the guts of the mealworm beetle, Tenebrio molitor. The structures of the pentaminomycins were determined to be cyclic pentapeptides containing a modified ...
Sunghoon Hwang, Ly Thi Huong Luu Le, Shin-Il Jo, Jongheon Shin, Min Jae Lee, Dong-Chan Oh   +5 more
doaj   +1 more source