Nonribosomal Peptide Synthetases in Animals. [PDF]
Genes (Basel), 2023 Nonribosomal peptide synthetases (NRPSs) are a class of cytosolic enzymes that synthesize a range of bio-active secondary metabolites including antibiotics and siderophores. They are widespread among both prokaryotes and eukaryotes but are considered rare among animals.
Suring W +5 more
europepmc +4 more sources
Nonribosomal Peptide Synthesis Definitely Working Out of the Rules [PDF]
Microorganisms, 2022 Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous structural diversity and a broad range of biological activities useful in the medical and agro-ecological fields.
Matthieu Duban +2 more
doaj +2 more sources
Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases [PDF]
Marine DrugsNonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents.
Mengli Zhang +5 more
doaj +2 more sources
Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells [PDF]
Beilstein Journal of Organic ChemistryThe adenylation (A) domain is essential for non-ribosomal peptide synthetases (NRPSs), which synthesize various peptide-based natural products, including virulence factors, such as siderophores and genotoxins.
Fumihiro Ishikawa +3 more
doaj +2 more sources
Discovery of Acyl-Surugamide A2 from Marine Streptomyces albidoflavus RKJM-0023—A New Cyclic Nonribosomal Peptide Containing an N-ε-acetyl-L-lysine Residue [PDF]
MoleculesWe report the discovery of a novel cyclic nonribosomal peptide (NRP), acyl-surugamide A2, from a marine-derived Streptomyces albidoflavus RKJM-0023 (CP133227).
Zacharie A. Maw +5 more
doaj +2 more sources
BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure
Computational and Structural Biotechnology Journal, 2022 Nonribosomal peptides are a class of secondary metabolites synthesized by multimodular enzymes named nonribosomal peptide synthetases and mainly produced by bacteria and fungi.
Dmitry N. Konanov +3 more
doaj +1 more source
A Nonribosomal System of Peptide Biosynthesis [PDF]
European Journal of Biochemistry, 1996 This review covers peptide structures originating from the concerted action of enzyme systems without the direct participation of nucleic acids. Biosynthesis proceeds by formation of linear peptidyl intermediates which may be enzymatically modified as well as transformed into specific cyclic structures.
H, Kleinkauf, H, Von Döhren
openaire +2 more sources
Biosynthetic Functionalization of Nonribosomal Peptides
Journal of the American Chemical Society, 2021 Nonribosomal peptides (NRPs) are a therapeutically important class of secondary metabolites that are produced by modular synthetases in assembly-line fashion. We previously showed that a single Trp-to-Ser mutation in the initial Phe-loading adenylation domain of tyrocidine synthetase completely switches the specificity toward clickable analogues.
David L. Niquille +3 more
openaire +3 more sources
mSystems, 2021 Bacillus subtilis produces a wide range of secondary metabolites providing diverse plant growth-promoting and biocontrol abilities. These secondary metabolites include nonribosomal peptides with strong antimicrobial properties, causing either cell lysis,
Heiko T. Kiesewalter +10 more
doaj +1 more source
Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis
Nature Communications, 2021 Nonribosomal lipopeptides contain an acyl chain important for bioactivity, but its incorporation into the peptidyl backbone, mediated by the starter condensation (Cs) domain of nonribosomal peptide synthases, is not fully understood.
Lin Zhong +10 more
doaj +1 more source