Results 21 to 30 of about 494,637 (215)
Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains [PDF]
, 2023 The adenylation reaction has been a subject of scientific intrigue since it was first recognized as essential to many biological processes, including the homeostasis and pathogenicity of some bacteria and the activation of amino acids for protein ...
Jaclyn, Winter, Stephanie , Heard
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A Nonribosomal System of Peptide Biosynthesis [PDF]
European Journal of Biochemistry, 1996 This review covers peptide structures originating from the concerted action of enzyme systems without the direct participation of nucleic acids. Biosynthesis proceeds by formation of linear peptidyl intermediates which may be enzymatically modified as well as transformed into specific cyclic structures.
H, Kleinkauf, H, Von Döhren
openaire +2 more sources
Biosynthetic Functionalization of Nonribosomal Peptides
Journal of the American Chemical Society, 2021 Nonribosomal peptides (NRPs) are a therapeutically important class of secondary metabolites that are produced by modular synthetases in assembly-line fashion. We previously showed that a single Trp-to-Ser mutation in the initial Phe-loading adenylation domain of tyrocidine synthetase completely switches the specificity toward clickable analogues.
David L. Niquille +3 more
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mSystems, 2021 Bacillus subtilis produces a wide range of secondary metabolites providing diverse plant growth-promoting and biocontrol abilities. These secondary metabolites include nonribosomal peptides with strong antimicrobial properties, causing either cell lysis,
Heiko T. Kiesewalter +10 more
doaj +1 more source
PARAS: High-Accuracy Machine Learning of Substrate Specificities in Nonribosomal Peptide Synthetases. [PDF]
JACS AuInternational audienceNonribosomal peptides are chemically and functionally diverse natural products with important applications in medicine and agriculture.
Terlouw BR +17 more
europepmc +3 more sources
A non-canonical NRPS is involved in the synthesis of fungisporin and related hydrophobic cyclic tetrapeptides in Penicillium chrysogenum. [PDF]
PLoS ONE, 2014 The filamentous fungus Penicillium chrysogenum harbors an astonishing variety of nonribosomal peptide synthetase genes, which encode proteins known to produce complex bioactive metabolites from simple building blocks. Here we report a novel non-canonical
Hazrat Ali +10 more
doaj +1 more source
NORINE: a database of nonribosomal peptides [PDF]
Nucleic Acids Research, 2007 Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows peptide production. It is performed by huge protein complexes called nonribosomal peptide synthetases (NRPSs).
Caboche, Ségolène +5 more
openaire +4 more sources
Frontiers in Catalysis, 2023 In nonribosomal peptide synthesis, condensation (C) domains are key catalytic domains that most commonly link carrier protein bound substrates to form peptides or depsipeptides.
Y. T. Candace Ho +28 more
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Expanding the toolbox for engineering nonribosomal peptide synthetases [PDF]
, 2023 Nonribosomal peptide synthetases (NRPSs) are an important source of pharmaceutically valuable natural products, including antibiotics. In depth understanding of enzymatic interactions responsible for the biosynthesis of these compounds by NRPSs is ...
Pourmasoumi, Farzaneh
core +1 more source
Biosynthesis and engineering of the nonribosomal peptides with a C-terminal putrescine
Nature Communications, 2023 The broad bioactivities of nonribosomal peptides rely on increasing structural diversity. Genome mining of the Burkholderiales strain Schlegelella brevitalea DSM 7029 leads to the identification of a class of dodecapeptides, glidonins, that feature ...
Hanna Chen +10 more
doaj +1 more source