Results 61 to 70 of about 494,637 (215)

Dissecting and Exploiting Nonribosomal Peptide Synthetases

Acta Biochimica et Biophysica Sinica, 2004
A large number of therapeutically useful cyclic and linear peptides of bacteria or fungal origin are synthesized via a template-directed, nucleic-acid-independent nonribosomal mechanism. This process is carried out by mega-enzymes called nonribosomal peptide synthetases (NRPSs).
Qing-Tao, Shen, Xiu-Lan, Chen, Cai-Yun, Sun, Yu-Zhong, Zhang   +3 more
openaire   +2 more sources

Prediction of monomer isomery in Florine: a workflow dedicated to nonribosomal peptide discovery. [PDF]

PLoS ONE, 2014
Nonribosomal peptides represent a large variety of natural active compounds produced by microorganisms. Due to their specific biosynthesis pathway through large assembly lines called NonRibosomal Peptide Synthetases (NRPSs), they often display complex ...
Thibault Caradec, Maude Pupin, Aurélien Vanvlassenbroeck, Marie-Dominique Devignes, Malika Smaïl-Tabbone, Philippe Jacques, Valérie Leclère   +6 more
doaj   +1 more source

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Metabolites, 2023
Three novel lipopeptides, PM130391 (1), PM130392 (2), and PM140293 (3) were obtained from cultures of Streptomyces tuirus PHM034 isolated from a marine sediment.
Ana Ceniceros, Librada Cañedo, Carmen Méndez, Carlos Olano, Carmen Schleissner, Carmen Cuevas, Fernando de la Calle, José A. Salas   +7 more
doaj   +1 more source

Antibacterial Property of a Coral-Associated Bacterium Pseudoalteromonas luteoviolacea Against Shrimp Pathogenic Vibrio harveyi (In Vitro Study)

Hayati Journal of Biosciences, 2005
A coral-associated bacterium was successfully screened for secondary metabolites production based on PCR amplification of the nonribosomal peptide synthetase gene and was identified as closely related to Pseudoalteromonas luteoviolacea based on its 16S ...
OCKY KARNA RADJASA, TORBEN MARTENS, HANS-PETER GROSSART, AGUS SABDONO, MEINHARD SIMON, TONNY BACHTIAR   +5 more
doaj   +3 more sources

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Novel chemical probes for the investigation of nonribosomal peptide assembly [PDF]

, 2017
Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights
Manuela Tosin, Y. T. C. Ho, Bushell, Dexter P., Ho, Y. T. Candace, Ghiringhelli, Francesca, Havemann, Judith, O. Köstner, Wilkening, Ina, E. Riva, Daniel J. Leng, Elena Riva, Riva, Elena, Judith Havemann, Francesca Ghiringhelli, J. Havemann, Otto Köstner, Leng, Daniel J., Passarella, Daniele, Dexter P. Bushell, I. Wilkening, Y. T. Candace Ho, D. P. Bushell, D. Passarella, M. Tosin, Daniele Passarella, F. Ghiringhelli, Ina Wilkening, Tosin, Manuela, Köstner, Otto, D. J. Leng   +29 more
core   +1 more source

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis

Nature Communications
Polyketides and nonribosomal peptides are important natural product classes with wide-ranging medical and agricultural applications. The analogous enzymatic logic employed by bacterial modular polyketide synthases (PKSs) and nonribosomal peptide ...
Munro Passmore, Xinyun Jian, Xinyi Zhao, Emmanuel L. C. de los Santos, Douglas M. Roberts, Józef R. Lewandowski, Matthew Jenner, Lona M. Alkhalaf, Gregory L. Challis   +8 more
doaj   +1 more source

Dereplication and de novo sequencing of nonribosomal peptides [PDF]

Nature Methods, 2009
Nonribosomal peptides (NRPs) are of great pharmacological importance, but there is currently no technology for high-throughput NRP 'dereplication' and sequencing. We used multistage mass spectrometry followed by spectral alignment algorithms for sequencing of cyclic NRPs. We also developed an algorithm for comparative NRP dereplication that establishes
Ng, Julio, Bandeira, Nuno, Liu, Wei-Ting, Ghassemian, Majid, Simmons, Thomas L., Gerwick, William, Linington, Roger, Dorrestein, Pieter, Pevzner, Pavel   +8 more
openaire   +2 more sources

Reengineering and Discovery of Nonribosomal Peptide Synthetases [PDF]

, 2010
Nonribosomal peptides are an important class of natural products including the life-saving antibiotics penicillin and vancomycin and the deadly microcystins and cereulide. This important category of natural products is thus a focus of many research labs
Evans, Bradley S.
core  

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
G. L. Challis, Challis, Gregory L.
core   +1 more source