Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis
Nature Communications, 2021 Nonribosomal lipopeptides contain an acyl chain important for bioactivity, but its incorporation into the peptidyl backbone, mediated by the starter condensation (Cs) domain of nonribosomal peptide synthases, is not fully understood.
Lin Zhong +10 more
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Nonribosomal Peptide Synthesis Definitely Working Out of the Rules [PDF]
Microorganisms, 2022 Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous structural diversity and a broad range of biological activities useful in the medical and agro-ecological fields.
Matthieu Duban +2 more
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, 2009 Nonribosomal peptides are a diverse group of compounds synthesized via modular nonribosomal peptide synthetase (NRPS) enzyme complexes. They are produced by a variety of prokaryotes, including streptomycetes, bacillus, and cyanobacteria, and lower-order eukaryotes such as fungi and sponges.
Roberts, Alexandra A. +2 more
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Decoding and reprogramming fungal iterative nonribosomal peptide synthetases [PDF]
Nature Communications, 2017 Nonribosomal peptides are important bioactive molecules that are synthetized by enzymes containing several catalytic domains. Here the authors describe the catalytic mechanism of fungal nonribosomal peptide synthetases and present an approach to modify ...
Dayu Yu +3 more
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Life, 2020 (1) Background: Phytohabitans is a recently established genus belonging to rare actinomycetes. It has been unclear if its members have the capacity to synthesize diverse secondary metabolites.
Hisayuki Komaki, Tomohiko Tamura
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Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach [PDF]
Advanced ScienceNonribosomal peptide (NRP) antibiotics exhibit potent biological activities and are broadly used in clinical therapy. Because most microorganisms are difficult to culture and many antibiotic biosynthetic genes are silent, traditional activity tracking ...
Keyi Chen +9 more
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Synthesis of the Nonribosomal Peptide Phevalin and Analogs [PDF]
The Journal of Organic Chemistry, 2019 Phevalin, a cyclic nonribosomal peptide produced by Staphylococcus aureus, has intriguing biological properties. A synthetic route to access phevalin and similar pyrazinone natural products tyrvalin, leuvalin, phileucin, and a few synthetic analogs is described.
Remya Ramesh +3 more
openaire +3 more sources
Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential
Frontiers in Pharmacology, 2017 Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc.
Shivankar Agrawal +5 more
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Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases [PDF]
Marine DrugsNonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents.
Mengli Zhang +5 more
doaj +2 more sources
Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells [PDF]
Beilstein Journal of Organic ChemistryThe adenylation (A) domain is essential for non-ribosomal peptide synthetases (NRPSs), which synthesize various peptide-based natural products, including virulence factors, such as siderophores and genotoxins.
Fumihiro Ishikawa +3 more
doaj +2 more sources