Results 111 to 120 of about 557,797 (165)

FRET Monitoring of a Nonribosomal Peptide Synthetase Elongation Module Reveals Carrier Protein Shuttling between Catalytic Domains. [PDF]

Angew Chem Int Ed Engl, 2022
Rüschenbaum J, Steinchen W, Mayerthaler F, Feldberg AL, Mootz HD.   +4 more
europepmc   +1 more source

Massetolide A biosynthesis in Pseudomonas fluorescens [PDF]

, 2007
Kock, M.J.D., de, T. A. van Beek, Bruijn, I., de, I. de Bruijn, Raaijmakers, J.M., Beek, T.A., van, J. M. Raaijmakers, M. J. D. de Kock, Waard, P., de, P. de Waard   +9 more
core   +1 more source

Alternative enzymatic pathways to penicillin antibiotics

Nature Communications
The discovery of penicillin, more than a century ago, has been one of the most significant advances in medicine. Despite the growing threat of antimicrobial resistance, which has rendered many other antibiotics ineffective, penicillin derivatives remain ...
Puja Saha, Guangcai Xu, Deepanjan Panda, Duncan Smith, Wei Li Thong, Luke Ward, Luis Bering, Sebastian Cuesta-Hoyos, Sarah A. Shepherd, Jason Micklefield   +9 more
doaj   +1 more source

A Conserved Nonribosomal Peptide Synthetase in Xenorhabdus bovienii Produces Citrulline-Functionalized Lipopeptides. [PDF]

J Nat Prod, 2021
Li JH, Cho W, Hamchand R, Oh J, Crawford JM.   +4 more
europepmc   +1 more source

Accurate Substrate-Like Probes for Trapping Late-Stage Intermediates in Nonribosomal Peptide Synthetase Condensation Domains. [PDF]

ACS Chem Biol, 2022
Wheadon MJ, Townsend CA.
europepmc   +1 more source

In vitro characterization of nonribosomal peptide synthetase-dependent O-(2-hydrazineylideneacetyl)serine synthesis indicates a stepwise oxidation strategy to generate the α-diazo ester moiety of azaserine. [PDF]

Chem Sci, 2023
Shikai Y, Kawai S, Katsuyama Y, Ohnishi Y.   +3 more
europepmc   +1 more source

Structural characterization of a PCP-R didomain from an archaeal nonribosomal peptide synthetase reveals novel interdomain interactions. [PDF]

J Biol Chem, 2021
Deshpande S, Altermann E, Sarojini V, Lott JS, Lee TV.   +4 more
europepmc   +1 more source

Structure of a stand-alone homodimeric nonribosomal peptide synthetase condensation domain reveals occlusion of the canonical carrier-protein interface. [PDF]

J Biol Chem
Singh J, Grant TD, Gulick AM.
europepmc   +1 more source

Degradation of Nonribosomal Peptide Synthetase Megasynthetases SrfAA and SrfAB by Acyldepsipeptide-Activated ClpP in Bacillus Subtilis. [PDF]

Chembiochem
Ishikawa F, Uchida C, Ohnishi R, Imai T, Tanabe G.   +4 more
europepmc   +1 more source

Teicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks. [PDF]

Biochemistry
Ratnayake MS, Jian X, Tailhades J, Challis GL, Hansen MH, Lewandowski JR, Cryle MJ.   +6 more
europepmc   +1 more source