Results 91 to 100 of about 557,797 (165)

Design of α‑Keto Carboxylic Acid Dimers by Domain Recombination of Nonribosomal Peptide Synthetase (NRPS)-Like Enzymes

, 2019
Nonribosomal peptide synthetase (NRPS)-like enzymes comprising A–T–TE architectures catalyze the dimerization of α-keto carboxylic acids leading to the formation of hydroxybenzoquinones or lactones.
Kristin Öqvist (6169292), Elisabeth Hühner (6169289), Shu-Ming Li (1523233)   +2 more
core   +1 more source

Methylation-Dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis

, 2015
Biochemical studies of purified and dissected fungal polyketide synthase and nonribosomal peptide synthetase (PKS-NRPS) hybrid enzymes involved in biosynthesis of pseurotin and aspyridone indicate that one α-methylation step during polyketide synthesis ...
Kenji Watanabe (75040), Yi Tang (55726), Yuta Tsunematsu (1311840), Mancheng Tang (1347630), Wei Xu (28953), Yi Zou (439002)   +5 more
core   +1 more source

Identification of the lipodepsipeptide selethramide encoded in a giant nonribosomal peptide synthetase from a Burkholderia bacterium. [PDF]

Proc Natl Acad Sci U S A, 2023
Romanowski SB, Lee S, Kunakom S, Paulo BS, Recchia MJJ, Liu DY, Cavanagh H, Linington RG, Eustáquio AS.   +8 more
europepmc   +1 more source

NUCLEAR MAGNETIC RESONANCE CHARACTERIZATION OF AN UNUSUAL 37 KILODALTON NONRIBOSOMAL PEPTIDE SYNTHETASE EPIMERIZATION DOMAIN [PDF]

, 2018
Yersiniabactin synthetase is a megadalton nonribosomal peptide synthetase that produces the iron-chelator yersiniabactin, which is essential for parasitic growth of Yersinia pestis, the etiological agent of plague.
Nichols, Scott Robert
core  

Desymmetrization of Cyclodepsipeptides by Assembly Mode Switching of Iterative Nonribosomal Peptide Synthetases

, 2019
Nonribosomal peptide synthetases assemble a considerable number of structurally complex peptides of pharmacological importance. This turns them into important biosynthetic machineries for peptide diversification by engineering approaches.
Sylvester Hoffmann (6481823), Roderich D. Süssmuth (1432969), Charlotte Steiniger, Sylvester Hoffmann, Charlotte Steiniger (6481820), Roderich D. Süssmuth   +5 more
core   +1 more source

Introduction of a non-natural amino acid into a nonribosomal peptide antibiotic by modification of adenylation domain specificity

, 2012
Calcium-dependent antibiotics (CDA) are cyclic lipopeptides assembled by nonribosomal peptide synthetase (NRPS) enzymes. Active site modification of the 3-methyl glutamate activating adenylation (A) domain of the CDA NRPS enables the incorporation of ...
Nunns, L, Struck, A-W, Micklefield, J, Nunns, Laura, Majid Al Nakeeb, Laura Nunns, Struck, Anna Winona, Richard Lewis, Lewis, R, Thirlway, J, Styles, M, Colin P. Smith, Styles, Matthew, Anna‐Winona Struck, Al Nakeeb, Majid, Micklefield, Jason, Thirlway, Jenny, Jason Micklefield, Smith, CP, Lewis, Richard, Al Nakeeb, M, Smith, Colin P., Matthew Styles, Jenny Thirlway   +23 more
core   +1 more source

SCREENING OF SECONDARY METABOLITE-PRODUCING BACTERIA ASSOCIATED WITH CORALS USING 16S rDNA-BASED APPROACH [PDF]

, 2003
A total of 42 coral-associated bacteria were screened for their ability to produce secondary metabolites by using 16S rDNA-based approach. A specific oligonucleotides primer was used to amplify DNA non-ribosomal peptide synthetase (NRPS).
Sabdono, Agus, Karna Radjasa, Ocky
core   +1 more source

Dynamics and mechanistic interpretations of nonribosomal peptide synthetase cyclization domains. [PDF]

Curr Opin Chem Biol, 2023
Gnann AD, Marincin K, Frueh DP, Dowling DP.   +3 more
europepmc   +1 more source

Nonribosomal peptide synthetase genes in the genome of Fusarium graminearum, causative agent of wheat head blight

, 2005
Fungal nonribosomal peptide synthetases (NRPSs) are responsible for the biosynthesis of numerous metabolites which serve as virulence factors in several plant-pathogen interactions. The aim of our work was to investigate the diversity of these genes in a
S. Kocsubé, Kocsubé, S., Beáta Tóth, Mesterházy, Á., Tóth, Beáta, Á. Mesterházy, Varga, J., J. Varga   +7 more
core   +1 more source

Sesquicilins A–H: 11-mer peptaibols with selective antibacterial activity against foodborne pathogens in aquatic products

Aquaculture and Fisheries
Antimicrobial agents with favourable food safety profiles are urgently needed to control human pathogenic bacteria associated with aquatic products. A mass spectrometry- and bioassay-guided screening approach was employed to identify structurally novel ...
Kainan Song, Wenhua Li, Yan Zhang, Liwen Zhang, Qun Yue, Zhigang Zhou, Chen Wang, Yuquan Xu   +7 more
doaj   +1 more source