Results 71 to 80 of about 557,797 (165)

Determining the Sequence of Two Colibactin Genes, clbN and clbB, in Some Clinical Isolates of E. coli

Medical Journal of Babylon
Background: Escherichia coli is a widespread human-infecting bacterium that can produce the genotoxin colibactin, which is encoded by the pks pathogenicity island and has been reported as a determinant of bacterial virulence.
Noor Ismeal Nasser, Mohammed Sabri Abdul-Razzag, Nadia Mudher AL-Hili   +2 more
doaj   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science
Nonribosomal peptide (NRP) antibiotics exhibit potent biological activities and are broadly used in clinical therapy. Because most microorganisms are difficult to culture and many antibiotic biosynthetic genes are silent, traditional activity tracking ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
doaj   +1 more source

Interdomain and Intermodule Organization in Epimerization Domain Containing Nonribosomal Peptide Synthetases

, 2016
Nonribosomal peptide synthetases are large, complex multidomain enzymes responsible for the biosynthesis of a wide range of peptidic natural products. Inherent to synthetase chemistry is the thioester templated mechanism that relies on protein/protein ...
Naga Sandhya Guntaka (2852846), Wei-Hung Chen (693540), Kunhua Li (1576657), Steven D. Bruner (1576660)   +3 more
core   +1 more source

Draft genome sequence of a porcine commensal, Rothia nasimurium, encoding a nonribosomal peptide synthetase predicted to produce the ionophore antibiotic valinomycin

, 2017
We report the draft whole-genome sequence of Rothia nasimurium isolated from a porcine tonsil. The genome encodes a nonribosomal peptide synthetase predicted to produce valinomycin, a cyclic dodecadepsipeptide ionophore. Previously, valinomycin was known
Gaiser, Rogier A., Rogier A. Gaiser, Peter van Baarlen, Michiel Kleerebezem, Medema, Marnix H., Baarlen, Peter, van, Marnix H. Medema, Wells, Jerry M., Jerry M. Wells, Kleerebezem, Michiel   +9 more
core   +1 more source

Engineering the future of medicine: Natural products, synthetic biology and artificial intelligence for next‐generation therapeutics

Clinical and Translational Medicine
The eXchange Unit between Thiolation domains approach and artificial intelligence (AI)‐driven tools like Synthetic Intelligence are transforming nonribosomal peptide synthetase and polyketide synthase engineering, enabling the creation of novel bioactive
Emre F. Bülbül, Helge B. Bode, Steven Schmitt, Kenan A. J. Bozhüyük   +3 more
doaj   +1 more source

Nonribosomal peptides

, 2009
Nonribosomal peptides are a diverse group of compounds synthesized via modular nonribosomal peptide synthetase (NRPS) enzyme complexes. They are produced by a variety of prokaryotes, including streptomycetes, bacillus, and cyanobacteria, and lower-order ...
Roberts, Alexandra A., Pearson, Leanne A. Pearson, Alexandra Roberts, Leanne Pearson, Brett Neilan, Neilan, Brett A.   +5 more
core   +1 more source

Non-ribosomal peptide synthetase (NRPS)-encoding products and their biosynthetic logics in Fusarium

Microbial Cell Factories
Fungal non-ribosomal peptide synthetase (NRPS)-encoding products play a paramount role in new drug discovery. Fusarium, one of the most common filamentous fungi, is well-known for its biosynthetic potential of NRPS-type compounds with diverse structural ...
Ziwei Huang, Wangjie Zhu, Yifan Bai, Xuelian Bai, Huawei Zhang   +4 more
doaj   +1 more source

The Contribution of Syringopeptin and Syringomycin to Virulence of Pseudomonas syringae pv. syringae strain B301D on the Basis of sypA and syrB1 Biosynthesis Mutant Analysis

Molecular Plant-Microbe Interactions, 2001
Sequencing of an approximately 3.9-kb fragment downstream of the syrD gene of Pseudomonas syringae pv. syringae strain B301D revealed that this region, designated sypA, codes for a peptide synthetase, a multifunctional enzyme involved in the thiotemplate
Brenda K. Scholz-Schroeder, Michael L. Hutchison, Ingeborg Grgurina, Dennis C. Gross   +3 more
doaj   +1 more source

Priming Type II Polyketide Synthases via a Type II Nonribosomal Peptide Synthetase Mechanism

, 2016
Benzoic acid priming of the enterocin and actinorhodin type II polyketide synthase complexes was accomplished in vitro via an unprecedented type II nonribosomal peptide synthetase-like mechanism involving the benzoate:acyl carrier protein (ACP) ligase ...
Qian Cheng (285039), Miho Izumikawa (1491067), Bradley S. Moore (1331865)   +2 more
core   +1 more source

Revealing the Inter-Module Interactions of Multi-Modular Nonribosomal Peptide Synthetases

, 2017
Nonribosomal peptide synthetase (NRPS) enzymes are large modular proteins involved in the biosynthesis of many important pharmaceuticals such as penicillin and cyclosporin. In this issue of Structure, Tarry et al.
J. Shaun Lott, T. Verne Lee, Lott, J Shaun, Lee, T Verne   +3 more
core   +1 more source