Results 51 to 60 of about 557,797 (165)
Molecular Plant-Microbe Interactions, 2015 The Sfp-type 4′-phosphopantetheinyl transferase Ppt1 is required for activation of nonribosomal peptide synthetases, including α-aminoadipate reductase (AAR) for lysine biosynthesis and polyketide synthases, enzymes that biosynthesize peptide and ...
Nur Ain Izzati Mohd Zainudin +7 more
doaj +1 more source
An Engineered Nonribosomal Peptide Synthetase Shows Opposite Amino Acid Loading and Condensation Specificity [PDF]
, 2021 Engineering of nonribosomal peptide synthetases (NRPS) has faced numerous obstacles despite being an attractive path towards novel bioactive molecules. Specificity filters in the nonribosomal peptide assembly line determine engineering success, but the
Philipp, Stephan +5 more
core +2 more sources
Sustainable Routes Toward Amino Acid‐Based Surfactants: Borrowing Hydrogen Catalysis and Beyond
ChemSusChem, Volume 19, Issue 20, 28 October 2026.This perspective examines how amino acid‐based surfactants become more sustainable only when molecular architecture is matched to an appropriate synthetic disconnection. Borrowing Hydrogen catalysis provides a central route to N‐alkylated derivatives, while enzymatic, biosynthetic, and renewable‐platform strategies complement it.
Maximilian Fellert, Ben L. Feringa
wiley +1 more source
Frontiers in Microbiology, 2019 Scedosporium species are opportunistic fungi which preferentially affect patients with underlying conditions such as immunosuppression or cystic fibrosis (CF).
Yohann Le Govic +8 more
doaj +1 more source
, 2016 The Nonribosomal Peptide Synthetase Enzyme DdaD Tethers Nβ-Fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic ...
J. Martin Bollinger (450755) +5 more
core +1 more source
Predicting Functional Diversity Within Enzyme Families: A Practical Perspective
ChemBioChem, Volume 27, Issue 19, 14 October 2026.Integrating machine learning into enzyme discovery requires navigating the trade‐offs between data quantity and quality. This article provides a best‐practice framework for developing robust predictors, focusing on mitigating bias in biochemical datasets, implementing systematic “cold‐drug” validation strategies, and utilizing explainable artificial ...
Nika Sokolova, Kristina Haslinger
wiley +1 more source
BMC Research Notes, 2020 Objective A Paenibacillus strain isolated in previous research exhibited antimicrobial activity against relevant human pathogens including Staphylococcus aureus and Listeria monocytogenes.
Magdalena Pajor +3 more
doaj +1 more source
, 2016 Analysis of naphthyridinomycin gene cluster revealed that this antibiotic is generated by nonribosomal peptide synthetase (NRPS) machinery. However, four modules encoded by two genes do not correspond with the structural units in the final product ...
Yue Zhang (30585) +7 more
core +1 more source
On the Evolution of Nonribosomal Peptide Synthetase Gene Clusters in Cyanobacteria [PDF]
, 2007 Cyanobacteria from genera Anabaena, Microcystis and Planktothrix produce a wide selection of nonribosomal peptides, e.g. microcystins and cyanopeptolins.
Tooming-Klunderud, Ave
core
Chapter 14 Biosynthesis of Nonribosomal Peptide Precursors
, 2009 Nonribosomal peptides are natural products typically of bacterial and fungal origin. These highly complex molecules display a broad spectrum of biological activities, and have been exploited for the development of immunosuppressant, antibiotic ...
Wilkinson, Barrie +3 more
core +1 more source