Results 41 to 50 of about 557,797 (165)

Semi‐Artificial Photosynthesis Enables Light‐Driven Biomanufacturing in Non‐Photosynthetic Bacteria

Advanced Science, EarlyView.
A non‐invasive strategy exploits endogenous H2S metabolism in B. subtilis to drive in situ CdS biomineralization, enabling tight bio‐abiotic contact without genetic modification. Light harvested by the biomineralized nanoparticles powers NADPH regeneration, elevating 2’‐fucosyllactose and surfactin titres two‐ to three‐fold.
Jie Zheng, Anqi Tong, Wenxin Li, Meng Qiao, Yang Gu, Muhammad Sohail, Shan He, Sheng Yang, Xing Zhang   +8 more
wiley   +1 more source

ANTIFOULING ACTIVITY OF BACTERIA ASSOCIATED WITH SOFT CORAL Sarcophyton sp. AGAINST MARINE BIOFILMFORMING BACTERIA [PDF]

, 2006
Marine bacteria associated with soft coral Sarcophyton sp collected from vicinity of Peucang island, Ujung Kulon, West Java, were successfully screened for antifouling activity against marine biofilm-forming bacteria isolated from the surrounding ...
Radjasa, Ocky Karna, Sabdono, Agus
core   +1 more source

Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl‐Substituted, α‐Oxidized γ‐Amino Acids

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang, Alexander Popoff, Maja Hunter, Guangzhi Dai, Ronald Garcia, Huixin Xu, Haowen Zhao, Asfandyar Sikandar, Liujie Huo, Rolf Müller, Chengzhang Fu   +10 more
wiley   +2 more sources

Expanding the Chemical Space of Nonribosomal Peptide Synthetase-like Enzymes by Domain and Tailoring Enzyme Recombination

, 2018
The potential of tailoring enzymes in combination with engineered hybrid nonribosomal peptide synthetase-like enzymes was explored and resulted in methylated and prenylated forms of novel natural products, highlighting the possibilities and limitations ...
Clay C. C. Wang, Johannes W. A. van Dijk, Clay C. C. Wang (313310), Johannes W. A. van Dijk (3384221)   +3 more
core   +1 more source

Epoxinnamide: An Epoxy Cinnamoyl-Containing Nonribosomal Peptide from an Intertidal Mudflat-Derived Streptomyces sp.

Marine Drugs, 2022
Cinnamoyl-containing nonribosomal peptides (CCNPs) form a unique family of actinobacterial secondary metabolites and display various biological activities.
Sangwook Kang, Jaeho Han, Sung Chul Jang, Joon Soo An, Ilnam Kang, Yun Kwon, Sang-Jip Nam, Sang Hee Shim, Jang-Cheon Cho, Sang Kook Lee, Dong-Chan Oh   +10 more
doaj   +1 more source

ExMODE: A comprehensive resource for extremophile genomic and functional exploration

iMetaOmics, EarlyView.
ExMODE (https://db.genomics.cn/exmode/) integrates 3518 samples to build a unified extremophile resource, which hosts 1.35 billion habitat‐specific non‐redundant genes, 5.25 million representative protein structures, 67,026 metagenome‐assembled genomes (MAGs), and 164,132 biosynthetic gene clusters (BGCs). By combining sequence‐, structure‐, and genome‐
Denghui Li, Kailong Ma, Xiaoqiang Li, Jieni Wang, Zhen Cui, Yulu Zhang, Weiwen Wang, Jiawei Tong, Yang Guo, Zongan Wang, Peiyun Zeng, Jieyu Wang, Xiaokai Xu, Nannan Zhang, Yingying Zhang, Jing Chen, Qingjiang Hu, Wenzhen Yang, Zhiyong Li, Tao Yang, Wensi Du, Zhicheng Xu, Zhen Yue, Jian Wang, Guangyi Fan, Weijia Zhang, Xun Xu, Liujie Huo, Xiaofeng Wei, Liang Meng, Shanshan Liu   +30 more
wiley   +1 more source

A non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis

Beilstein Journal of Organic Chemistry, 2016
Auriculamide is the first natural product known from the predatory bacterium Herpetosiphon aurantiacus. It is composed of three unusual building blocks, including the non-proteinogenic amino acid 3-chloro-L-tyrosine, the α-hydroxy acid L-isoleucic acid ...
Daniel Braga, Dirk Hoffmeister, Markus Nett   +2 more
doaj   +1 more source

The sypA, sypB, and sypC Synthetase Genes Encode Twenty-Two Modules Involved in the Nonribosomal Peptide Synthesis of Syringopeptin by Pseudomonas syringae pv. syringae B301D

Molecular Plant-Microbe Interactions, 2003
Syringopeptin is a necrosis-inducing phytotoxin, composed of 22 amino acids attached to a 3-hydroxy fatty acid tail. Syringopeptin, produced by Pseudomonas syringae pv. syringae, functions as a virulence determinant in the plant-pathogen interaction.
Brenda K. Scholz-Schroeder, Jonathan D. Soule, Dennis C. Gross   +2 more
doaj   +1 more source

Comparative genomics of dark septate endophytes: shedding light on the enigmatic lifestyle and biology of DSEs

New Phytologist, EarlyView.
Ancestral lifestyle reconstruction across the phylogeny of the 107 analysed fungal genomes. Summary Dark septate endophytes (DSE) are widespread root‐colonising fungi with poorly understood lifestyle and ecological functions. We investigated their genomic traits, sexual reproduction signatures, carbohydrate‐active enzyme (CAZyme) and secondary ...
Sándor Csíkos, Zsolt Merényi, Dániel G. Knapp, Anna Lipzen, Kurt LaButti, Jasmyn Pangilinan, Robert Riley, Sajeet Haridas, Asaf Salamov, Kerrie Barry, Alan Kuo, Elodie Drula, Igor V. Grigoriev, Bernard Henrissat, Francis Martin, László G. Nagy, Gábor M. Kovács   +16 more
wiley   +1 more source

Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells

Beilstein Journal of Organic Chemistry
The adenylation (A) domain is essential for non-ribosomal peptide synthetases (NRPSs), which synthesize various peptide-based natural products, including virulence factors, such as siderophores and genotoxins.
Fumihiro Ishikawa, Sho Konno, Hideaki Kakeya, Genzoh Tanabe   +3 more
doaj   +1 more source