Results 81 to 90 of about 557,797 (165)

ANTI-BACTERIAL PROPERTY OF A CORAL-ASSOCIATED BACTERIUM Bacillus sp. AGAINST CORAL PATHOGENIC [PDF]

, 2006
Marine organisms such as corals are frequently colonized by bacteria that may be pathogenic to them. One of the means by which they are able to combat microbial attack is by chemical defense.
Radjasa, Ocky Karna, Sabdono, Agus
core   +1 more source

Suppression of linear side products by macromolecular crowding in nonribosomal enterobactin biosynthesis

, 2008
Nonribosomal enterobactin synthetase of Escherichia coli was found to prematurely release a large amount of linear precursors in an in vitro reconstitution.
Zheng, Suilan, Guo, Zhihong, Jiang, Ming, Guo, Zu Feng   +3 more
core   +1 more source

Suppression of Linear Side Products by Macromolecular Crowding in Nonribosomal Enterobactin Biosynthesis

, 2016
Nonribosomal enterobactin synthetase of Escherichia coli was found to prematurely release a large amount of linear precursors in an in vitro reconstitution.
Ming Jiang (11433), Zhihong Guo (404198), Zu-Feng Guo (2185165), Suilan Zheng (2389246)   +3 more
core   +1 more source

Unlocking probiotic potential: Non-ribosomal peptide synthetase (NRPS)-driven biosurfactant synthesis for industrial innovation

Frontiers in Industrial Microbiology
Non-ribosomal peptide synthetases (NRPS) are multi-modular enzymes that produce secondary metabolites. The diverse and functionally important biosurfactants derived from various microbes have numerous applications across multiple industries.
Kamini Pandey, Madhu Kumari, Barkha Singhal   +2 more
doaj   +1 more source

The role of the phosphopantetheinyltransferase enzyme, PswP, in the biosynthesis of antimicrobial secondary metabolites by Serratia marcescens Db10 [PDF]

, 2014
Phosphopantetheinyl transferase (PPTase) enzymes fulfil essential roles in primary and secondary metabolism in prokaryotes, archaea and eukaryotes. PPTase enzymes catalyse the essential modification of the carrier protein domain of fatty acid synthases ...
Gerc, Amy J., Stanley-Wall, Nicola R.; id_orcid, Coulthurst, Sarah J.; id_orcid   +2 more
core   +1 more source

Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines

Acta Pharmaceutica Sinica B
Ergopeptines or their derivatives are widely used for treating neurodegenerative and cerebrovascular diseases. The nonribosomal peptide synthetase—d-lysergyl peptide synthetase A (LPSA) determines ergopeptine formation but the detailed mechanism remains ...
Jing-Jing Chen, Ting Gong, Wei-Bo Wang, Tian-Jiao Chen, Jin-Ling Yang, Ping Zhu   +5 more
doaj   +1 more source

Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase–Polyketide Synthase Interface for Leinamycin Biosynthesis

, 2017
Leinamycin (LNM) is biosynthesized by a hybrid nonribosomal peptide synthetase (NRPS)–acyltransferase (AT)-less type I polyketide synthase (PKS). Characterization of LnmI revealed ketosynthase (KS)–acyl carrier protein (ACP)–KS domains at the NRPS–PKS ...
Chin-Yuan Chang (1769713), Guohui Pan (218646), Ben Shen (1309689), Yong Huang (15745), Gong-Li Tang (1829416)   +4 more
core   +1 more source

A Journey into the Blue: Current Knowledge and Emerging Insights into Marine-Derived Peptaibols

Marine Drugs
Peptaibols represent a large family of membrane-active, linear fungal peptides, with variable lengths from 5 to 21 α–amino acid residues. As products of nonribosomal peptide synthetase (NRPS) biosynthetic machinery, they encompass several non ...
Claudia Finamore, Carmen Festa, Mattia Cammarota, Simona De Marino, Maria Valeria D’Auria   +4 more
doaj   +1 more source

Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes

Beilstein Journal of Organic Chemistry, 2011
Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry responsible for the formation of these compounds have revealed fascinating mechanisms that are not, or only rarely, found in other microorganisms.
Jan-Christoph Kehr, Douglas Gatte Picchi, Elke Dittmann   +2 more
doaj   +1 more source

A portable pathway specific transcription factor-promoter circuit enables heterologous production of fungal nonribosomal peptides

Most fungal nonribosomal peptide synthetase (NRPS) biosynthetic gene clusters remain transcriptionally silent, severely restricting the discovery of bioactive peptide metabolites. Standard constitutive promoters fail to support robust expression of large.
Zedong Ren, Jie Fan, Peng-Lin Wei, Jinwei Ren, Wenbing Yin, Yuanyuan Li, Shengquan Zhang   +6 more
core   +1 more source