Results 101 to 110 of about 557,797 (165)

Biosynthesis of Antifungal Solanimycin May Involve an Iterative Nonribosomal Peptide Synthetase Module. [PDF]

ACS Chem Biol, 2023
Murphy AC, Corney M, Monson RE, Matilla MA, Salmond GPC, Leeper FJ.   +5 more
europepmc   +1 more source

A multifunctional PKS-NRPS megasynthetase in nematodes produces divergent signaling molecules that control different developmental arrests

Nature Communications
To maximize their reproductive success, nematodes not only must arrest their development in response to adverse growth conditions but also must quickly recover if conditions improve. However, the molecular signals that coordinate these transitions remain
Kevin Mai, Chi-Su Yoon, Dilip V. Prajapati, Yuelan Li, Rongrong Yu, Hanh Witte, Subhradeep Bhar, Likui Feng, David A. deGuzman, Elijah Abraham, Matthew T. Gordon, Surasree Rakshit, Melisa S. Gonzalez, Priya, Ralf J. Sommer, Rebecca A. Butcher   +15 more
doaj   +1 more source

Proof-Reading Thioesterase Boosts Activity of Engineered Nonribosomal Peptide Synthetase. [PDF]

ACS Chem Biol, 2022
Pourmasoumi F, De S, Peng H, Trottmann F, Hertweck C, Kries H.   +5 more
europepmc   +1 more source

ClusterCAD 2.0: an updated computational platform for chimeric type I polyketide synthase and nonribosomal peptide synthetase design. [PDF]

Nucleic Acids Res, 2023
Tao XB, LaFrance S, Xing Y, Nava AA, Martin HG, Keasling JD, Backman TWH.   +6 more
europepmc   +1 more source

Discovery and Biosynthesis of Azabicyclene, a Conserved Nonribosomal Peptide in Pseudomonas aeruginosa

, 2019
Azabicyclene, an azetidine-containing natural product, was identified using quorum-sensing molecules to upregulate expression of a gene cluster highly conserved in the human pathogen Pseudomonas aeruginosa. Mutational studies of the gene cluster revealed
Adam R. Lescallette (5767934), Bo Li, Jon B. Patteson (4573225), Jon B. Patteson, Bo Li (112195), Adam R. Lescallette   +5 more
core   +1 more source

Mutagenetic analysis of the biosynthetic pathway of tetramate bripiodionen bearing 3-(2H-pyran-2-ylidene)pyrrolidine-2,4-dione skeleton

Microbial Cell Factories
Background Natural tetramates are a family of hybrid polyketides bearing tetramic acid (pyrrolidine-2,4-dione) moiety exhibiting a broad range of bioactivities.
Haixia Zang, Yijia Cheng, Mengjia Li, Lin Zhou, Li-Li Hong, Hai Deng, Hou-Wen Lin, Yongjun Zhou   +7 more
doaj   +1 more source

Characterization and catalytic investigation of fungal single-module nonribosomal peptide synthetase in terpene-amino acid meroterpenoid biosynthesis. [PDF]

J Ind Microbiol Biotechnol, 2023
Tseng CC, Chen LX, Lee CF, Tu Z, Lin CH, Lin HC.   +5 more
europepmc   +1 more source

Structure elucidation and activity of kolossin A, the D-/L-Pentadecapeptide product of a giant nonribosomal peptide synthetase

, 2015
The largest continuous bacterial nonribosomal peptide synthetase discovered so far is described. It consists of 15 consecutive modules arising from an uninterrupted, fully functional gene in the entomopathogenic bacterium Photorhabdus luminescens.
Bode, H., Brachmann, Alexander O., Waterfield, Nick R., Heinemann, S., Fuchs, S., Waterfield, Nicholas R., Arndt, H., Jadhav, Kirtikumar B., Kaiser, M., Seyfarth, Lydia, Sack, Holger, Fuchs, Sebastian W., Dauth, C., Kaiser, Marcel, Arndt, Hans-Dieter, Sack, H., Bode, Helge B., Dauth, Christina, Brachmann, A., Jadhav, K., Heinemann, Stefan H., Seyfarth, L., Waterfield, N.   +22 more
core   +1 more source

TagR, a newly identified member of the MarR family of transcriptional regulators, represses the NRPS operon in Klebsiella oxytoca

Microbiology Spectrum
Toxigenic Klebsiella oxytoca strains produce the pyrrolobenzodiazepine enterotoxins tilimycin (TM) and tilivalline (TV), which contribute to the development of antibiotic-associated hemorrhagic colitis.
Cristopher Perez, Mario A. López-Luis, Carlos J. Jiménez-Sánchez, Fermín I. Hernández-Pompa, Diana Rodríguez-Valverde, Sandra Rivera-Gutiérrez, Roberto Rosales-Reyes, Fernando Chimal-Cázares, Jorge Soria-Bustos, Jorge A. Yañez-Santos, Maria L. Cedillo, Miguel A. De la Cruz, James G. Fox, Miguel A. Ares   +13 more
doaj   +1 more source

Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase. [PDF]

ACS Chem Biol, 2021
Morgan GL, Li K, Crawford DM, Aubé J, Li B.   +4 more
europepmc   +1 more source