Results 91 to 100 of about 208,237 (324)

Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.
Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +14 more
wiley   +1 more source

Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats

eLife
Extinction is a specific example of learning where a previously reinforced stimulus or response is no longer reinforced, and the previously learned behaviour is no longer necessary and must be modified.
Simon Lui, Ashleigh K Brink, Laura H Corbit   +2 more
doaj   +1 more source

Effects of Noradrenergic Stimulation Upon Context-Related Extinction Learning Performance and BOLD Activation in Hippocampus and Prefrontal Cortex Differ Between Participants Showing and Not Showing Renewal

Frontiers in Behavioral Neuroscience, 2019
While the neural structures mediating context-related renewal of extinction are well established, the neurotransmitter systems processing renewal remain elusive.
Silke Lissek, Anne Klass, Martin Tegenthoff   +2 more
doaj   +1 more source

The role of copper in disulfiram-induced toxicity and radiosensitisation of cancer cells. [PDF]

, 2013
Disulfiram has been used for several decades in the treatment of alcoholism. It now shows promise as an anti-cancer drug and radiosensitizer. Proposed mechanisms of action include the induction of oxidative stress and inhibition of proteasome activity ...
Babich, John W, Boyd, Marie, Mairs, Robert J., Rae, Colin, Sorensen, Annette, Tesson, M.   +5 more
core   +1 more source

Characterization of di‐gital, tri‐gital, and tetra‐gital temporal movement of systolic blood pressure on the arterial pulse waveform of rats at different vascular stiffness

Animal Models and Experimental Medicine, EarlyView.
The example of the time dependent fluctuation of systolic pressure on rat arterial pulse waveform in ms. The four levels of the systolic pressure fluctuation show di‐gital, tri‐gital and tetra‐gital fluctuation. The red dots represent particular heartbeats. Abstract Background An arterial stiffness is an indicator of many cardiovascular diseases.
Anton Misak, Lenka Tomasova, Marian Grman, Karol Ondrias   +3 more
wiley   +1 more source

Effect Of Different Doses Of Noradrenaline Against Ischemia-induced Ventricular Arrhythmias In Rat Heart In Vivo

Indian Pacing and Electrophysiology Journal, 2009
BackgroundThe present study was designed to evaluate the preconditioning effect of different doses of noradrenaline on ischemia-induced ventricular arrhythmias in open chest anesthetized rats.MethodsThe anaesthetized rats were subjected to 25 min of ...
Alireza Imani, Mahdieh Faghihi, Mansoor Keshavarz, Seyed Morteza Karimian, Somayeh Sadeghi Niaraki   +4 more
doaj  

Hormonal and Psychological Responses to a Single Cold-Water Immersion in Regularly Winter-Swimming Males

Applied Sciences
The psychological response to cold is complex. The present study aimed to determine if regular winter swimmers differed from those who did not practise winter swimming in terms of (1) daily perceived emotional states, (2) subjectively perceived ...
Aneta Teległów, Krzysztof Wrześniewski, Jan Blecharz   +2 more
doaj   +1 more source

Selective WGA uptake in the hippocampus from the locus coeruleus of DBH-WGA transgenic mice

Frontiers in Behavioral Neuroscience, 2012
We generated transgenic mice in which a transsynaptic tracer, wheat germ agglutinin (WGA), was specifically expressed in the locus coeruleus neurons under the control of the dopamine-β-hydroxylase gene promoter. WGA protein was produced in more than 95%
Susan G eWalling, Robert A.M. Brown, Nobuhiko eMIYASAKA, Yoshihiro eYoshihara, Carolyn W Harley   +4 more
doaj   +1 more source

Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]

, 2004
Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C., Laakmann, G., Schule, C.   +2 more
core   +1 more source

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention

Animal Models and Experimental Medicine, EarlyView.
This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
wiley   +1 more source