Results 31 to 40 of about 208,237 (324)

Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography [PDF]

, 2012
Preliminary investigation of the radioiodinated (S,S)-reboxetine analogue, 123I-INER, in baboons showed this tracer to have promise for imaging the noradrenaline transporter (NAT) using single photon emission computed tomography (SPECT).
Baldwin, Baldwin, Chang, Ding, Gandelman, Grandoso, Jobson, Jobson, Jobson, Kanegawa, Kiyono, Kung, Lakshmi, McConathy, Schou, Schou, Schou, Seibyl, Seneca, Smith, Stoddart, Tamagnan, Tavares, Tavares, Tejani-Butt, Zeng, Zoghbi   +26 more
core   +1 more source

Noradrenaline and serotonin-dependent sensitization of MSCs to noradrenaline

MethodsX
Stem and progenitor cells are characterized by peculiar mechanisms of hormonal regulation. Here we describe a protocol of analysis of hormonal cross-talk in adipose tissue derived multipotent mesenchymal stem cells (MSCs).
Vadim I. Chechekhin, Konstantin Yu. Kulebyakin, Natalia I. Kalinina, Pyotr A. Tyurin-Kuzmin   +3 more
doaj   +1 more source

Preclinical discovery of duloxetine for the treatment of depression [PDF]

, 2012
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María, Elorza, Julián, Micó Segura, Juan Antonio, Perez-Caballero, Laura, Torres-Sanchez, Sonia   +4 more
core   +2 more sources

Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]

, 2020
In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP, Baudel, MASM-A, Large, WA, Shi, J   +3 more
core   +1 more source

Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites

Journal of International Medical Research, 2020
Objective To identify factors associated with outcome of septic shock patients receiving high dose noradrenaline according to three primary infection sites.
Kang-song Wu, Dan-yan Gu, Ting-ting Wang, Bu-wen Yu, Kong-han Pan, Jian-cang Zhou   +5 more
doaj   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

A randomised controlled study of high intensity exercise as a dishabituating stimulus to improve hypoglycaemia awareness in people with type 1 diabetes:a proof of concept study [PDF]

, 2020
Aims/hypothesis Approximately 25% of people with type 1 diabetes have suppressed counterregulatory hormonal and symptomatic responses to insulin-induced hypoglycaemia, which renders them at increased risk of severe, disabling hypoglycaemia.
Farrell, Catriona M., Fournier, Paul, Hapca, Simona M., Jones, Timothy, McCrimmon, Rory J., McNeilly, Alison D., West, Daniel   +6 more
core   +4 more sources

Relationship between the tissue level of cyclic AMP and the fat cell size of human adipose tissue.

Journal of Lipid Research, 1978
The relationship between mean fat cell size, maximal tissue cyclic AMP concentration, and glycerol release was investigated in human subcutaneous adipose tissue incubated in vitro with or without isoprenaline or noradrenaline added at maximal effective ...
P Arner, J Ostman
doaj   +1 more source

Vascular responses of the extremities to transdermal application of vasoactive agents in Caucasian and African descent individuals [PDF]

, 2015
This is an accepted manuscript of an article published by Springer in European Journal of Applied Physiology on 04/04/2015, available online: https://doi.org/10.1007/s00421-015-3164-2 The accepted version of the publication may differ from the final ...
AC Shore, Army Medical surveillance activity, AT Koutsavlis, B Endrich, B Waeber, BJ Kim, C Cardillo, C Cardillo, CC Ungley, CC Ungley, Clare M. Eglin, CM Stein, CM Stein, CR Anderson, CS Thompson-Torgerson, D Bylund, D Miller, DA Rosenbaum, DF Kahn, DL Feairheller, DS Jones, DW DeGroot, E Clark, E Mata-Greenwood, FSC Golden, GA Conway, HA Daanen, HC Parkington, HP Rang, J Gainer, J Jia, J Jia, J Lundberg, James R. House, JE Burgess, JE Ramsay, JM Johnson, JP Noon, K Hope, K Komori, K Sauerstein, KK Griendling, KW Russell, L Ekenvall, L Kalinowski, LA Holowatz, LA Holowatz, M Honda, M Roustit, M Schmelz, M Shibasaki, MA Chotani, MA Chotani, MA Hashmi, Matthew J. Maley, ME Pueyo, Michael J. Tipton, MJ Easter, MJ Maley, MS Taylor, N Melikian, O Wilson, RF Furchgott, RG Hendry, RT Grant, RT Grant, SJ Duffy, SJ Morris, SJ Sarnoff, SR Bailey, T Lewis, TJ Cleophas, TM Mäkinen, WH Candler   +73 more
core   +4 more sources

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source