Results 141 to 150 of about 77,506 (299)

Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes

open access: yeseLife
Central noradrenergic (NA) neurons are key constituents of the respiratory homeostatic network. NA dysfunction is implicated in several developmental respiratory disorders including Congenital Central Hyperventilation Syndrome (CCHS), Sudden Infant Death
Yuan Chang   +4 more
doaj   +1 more source

The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression

open access: yesAdvanced Science, Volume 12, Issue 26, July 10, 2025.
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao   +7 more
wiley   +1 more source

Locus coeruleus integrity correlates with plasma soluble Axl levels in Alzheimer's disease patients

open access: yesAlzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION Locus coeruleus (LC) is one of the earliest structures altered in Alzheimer's disease (AD). Inflammation is also now considered critical in AD pathology, early stage included. However, no association between LC degeneration and the peripheral inflammation has been reported yet.
Alessandro Galgani   +9 more
wiley   +1 more source

Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease

open access: yesAnnals of Neurology, Volume 98, Issue 1, Page 136-146, July 2025.
Objective The objective of this study was to investigate the differences in cyclic alternating patterns (CAP) metrics, a non‐rapid eye movement (NREM) sleep physiological rhythm, among recently diagnosed patients with Parkinson's disease (PD), and individuals at high and low risk for developing PD based on genetic and prodromal risk.
Andrew Dagay   +5 more
wiley   +1 more source

Noradrenergic modulation of saccades in Parkinson’s disease

open access: yesBrain Communications
Abstract Noradrenaline is a powerful modulator of cognitive processes, including action decisions underlying saccadic control. Changes in saccadic eye movements are common across neurodegenerative diseases of ageing, including Parkinson’s disease.
Isabella F. Orlando   +11 more
openaire   +3 more sources

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