Results 141 to 150 of about 96,327 (352)
The futuristic manifolds of REM sleep
Summary Since one of its first descriptions 70 years ago, rapid eye movement sleep has continually inspired and excited new generations of sleep researchers. Despite significant advancements in understanding its neurocircuitry, underlying mechanisms and microstates, many questions regarding its function, especially beyond the early neurodevelopment ...
Liborio Parrino, Ivana Rosenzweig
wiley +1 more source
Improvement of the noradrenergic symptom cluster following treatment with milnacipran
Depression has a major impact on social functioning. Decreased concentration, mental and physical slowing, loss of energy, lassitude, tiredness, and reduced self-care are all symptoms related to reduced noradrenergic activity.
S. Kasper, D. Meshkat, A. Kutzelnigg
semanticscholar +1 more source
Narcolepsy and rapid eye movement sleep
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini+4 more
wiley +1 more source
There is abundant evidence for abnormalities of the norepinephrine (NE) and serotonin (5HT) neurotransmitter systems in depression and anxiety disorders. The majority of evidence supports underactivation of serotonergic function and complex dysregulation
K. Ressler, C. Nemeroff
semanticscholar +1 more source
Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli+12 more
wiley +1 more source
MORPHINE ANALGESIA AND THE BULBOSPINAL NORADRENERGIC SYSTEM: INCREASE IN THE CONCENTRATION OF NORMETANEPHRINE IN THE SPINAL CORD OF THE RAT CAUSED BY ANALGESICS [PDF]
Hirohito Shiomi, Hiroshi Takagi
openalex +1 more source
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont+5 more
wiley +1 more source
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core
Management of Adult Obstructive Sleep Apnoea: Many Questions, Not Enough Answers!
ABSTRACT Obstructive sleep apnoea (OSA) conveys a substantial global public burden due to its high prevalence and causative relationship with cardiometabolic diseases. The current diagnostic reliance on the apnoea/hypopnoea index (AHI) is insufficient to address the complex, multifaceted condition, and a revision of the standard criteria is urgently ...
Maria Stanczyk+4 more
wiley +1 more source
Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash+5 more
wiley +1 more source