Results 31 to 40 of about 7,845 (216)

The inhibition of the dorsal paragigantocellular reticular nucleus induces waking and the activation of all adrenergic and noradrenergic neurons: a combined pharmacological and functional neuroanatomical study. [PDF]

PLoS ONE, 2014
GABAergic neurons specifically active during paradoxical sleep (PS) localized in the dorsal paragigantocellular reticular nucleus (DPGi) are known to be responsible for the cessation of activity of the noradrenergic neurons of the locus coeruleus during ...
Olivier Clément, Sara Valencia Garcia, Paul-Antoine Libourel, Sébastien Arthaud, Patrice Fort, Pierre-Hervé Luppi   +5 more
doaj   +1 more source

Serotonergic and noradrenergic contributions to human motor cortical and spinal motoneuronal excitability [PDF]

arXiv, 2023
Animal models indicate that motor behaviour is shaped by monoamine neurotransmitters released diffusely throughout the brain and spinal cord. We present strong evidence that human motor pathways are equally affected by neuromodulation through noradrenergic and serotonergic projections arising from the brainstem.
arxiv  

The Role of Noradrenergic and Glutamatergic Signaling in Noradrenergic Neurons in Respiratory Control

The FASEB Journal, 2020
Central noradrenergic (NA) neurons are a critical component of the brainstem respiratory network that maintains blood CO2 and O2 levels through respiratory chemoreflexes. NA dysfunction is implicated in numerous developmental respiratory disorders such as the fatal Sudden Infant Death Syndrome (SIDS), Rett Syndrome, and Congenital Central ...
Russell S. Ray, Yuan Chang
openaire   +2 more sources

Mirtazapine for the Treatment of Chronic Pruritus

Medicines, 2019
Background: Chronic pruritus is a debilitating condition associated with a wide range of dermatologic, systemic and psychogenic etiologies. In patients with chronic pruritus that is refractory to conventional therapy, symptoms can significantly decrease ...
Raveena Khanna, Emily Boozalis, Micah Belzberg, John G. Zampella, Shawn G. Kwatra   +4 more
doaj   +1 more source

Noradrenergic neuromodulation of nonlinear bursting neurons controls critical dynamics [PDF]

arXiv, 2021
In order to remain adaptable to a dynamic environment, neural activity must be simultaneously both sensitive and stable. To solve this problem, the brain has been hypothesised to sit near a critical boundary. Yet, precisely how criticality and these opposing information processing modes are implemented in the brain remains elusive. A potential solution
arxiv  

Altered functional connectivity pattern of hippocampal subfields in individuals with objectively‐defined subtle cognitive decline and its association with cognition and cerebrospinal fluid biomarkers

European Journal of Neuroscience, Volume 56, Issue 12, Page 6227-6238, December 2022., 2022
Obj‐SCD is considered to be the preclinical phase of AD. Different hippocampal subfields show specific functions. Hippocampal dysfunction in Obj‐SCD reflects subtle cognitive impairment and AD‐specific pathological changes. Abstract Recent studies have shown that in the preclinical phase of Alzheimer's disease (AD), subtle cognitive changes can be ...
Tiantian Qiu, Qingze Zeng, Yusong Zhang, Xiao Luo, Xiaopei Xu, Xiaodong Li, Zhujing Shen, Kaicheng Li, Chao Wang, Peiyu Huang, Minming Zhang, Shouping Dai, Fei Xie, for the Alzheimer's Disease Neuroimaging Initiative   +13 more
wiley   +1 more source

SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex

Communications Biology, 2022
Loss of SLITRK1 results in altered behaviour and in increased noradrenergic projections in OCD-related neural circuits, suggesting that differences in noradrenergic signaling may contribute to numerous neurodevelopmental disorders, including OCD ...
Minoru Hatayama, Kei-ichi Katayama, Yukie Kawahara, Hayato Matsunaga, Noriko Takashima, Yoshimi Iwayama, Yoshifumi Matsumoto, Akinori Nishi, Takeo Yoshikawa, Jun Aruga   +9 more
doaj   +1 more source

Inhibition of noradrenergic signalling in rodent orbitofrontal cortex impairs the updating of goal-directed actions

eLife, 2023
In a constantly changing environment, organisms must track the current relationship between actions and their specific consequences and use this information to guide decision-making.
Juan Carlos Cerpa, Alessandro Piccin, Margot Dehove, Marina Lavigne, Eric J Kremer, Mathieu Wolff, Shauna L Parkes, Etienne Coutureau   +7 more
doaj   +1 more source

Magnetic resonance imaging Locus Coeruleus abnormality in amnestic Mild Cognitive Impairment is associated with future progression to dementia

European Journal of Neurology, Volume 30, Issue 1, Page 32-46, January 2023., 2023
The Magnetic Resonance Imaging features of Locus Coeruleus (LC) at baseline in Mild Cognitive Impairment subjects converting to dementia at follow‐up (cMCI) differ from those of non‐converting ones (ncMCI). This is specifically related to rostral LC and is more evident in the left LC.
Alessandro Galgani, Francesco Lombardo, Nicola Martini, Andrea Vergallo, Luca Bastiani, Harald Hampel, Hana Hlavata, Filippo Baldacci, Gloria Tognoni, Daniele De Marchi, Irene Ghicopulos, Sara De Cori, Francesca Biagioni, Carla Letizia Busceti, Roberto Ceravolo, Ubaldo Bonuccelli, Dante Chiappino, Gabriele Siciliano, Francesco Fornai, Nicola Pavese, Filippo Sean Giorgi   +20 more
wiley   +1 more source

Cellular composition and circuit organization of the locus coeruleus of adult mice

eLife, 2023
The locus coeruleus (LC) houses the vast majority of noradrenergic neurons in the brain and regulates many fundamental functions, including fight and flight response, attention control, and sleep/wake cycles.
Andrew McKinney, Ming Hu, Amber Hoskins, Arian Mohammadyar, Nabeeha Naeem, Junzhan Jing, Saumil S Patel, Bhavin R Sheth, Xiaolong Jiang   +8 more
doaj   +1 more source