Results 91 to 100 of about 504 (130)

The role of norharman in alcohol dependence and smoking: The potential inhibitory role of norharman on the urge for alcohol and nicotine use

Journal of Substance Use, 2005
The aim of this study was to investigate the role of the endogenous substance norharman in processes of alcohol and nicotine or tobacco dependence in both humans and animals. For this purpose heavy smokers and excessive alcohol drinkers were recruited, and rats were made dependent on alcohol and nicotine.
Fekkes, Durk, Spijkerman, R, Bongers, IL (Ilja), Eijnden, R   +3 more
openaire   +1 more source

Prototropic behavior of norharmane within ionic liquids

Journal of Photochemistry and Photobiology A: Chemistry, 2021
Abstract Ionic liquids are established as alternate solvents for several traditional organic solvents as well as aqueous-based media in many areas of chemistry. Proton transfer reactions exhibit a high dependency on the nature of the solubilizing media.
null Bhawna, Divya Dhingra, Ashish Pandey, Siddharth Pandey   +3 more
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Effects of the co-mutagen norharman in rats

Toxicology Letters, 1979
Abstract Studies were made on the acute and subacute toxic effects of the co-mutagen norharman when given orally to male Fischer strain rats. Animals were given diets containing 1500 ppm of norharman for 28 days, and 3 or 6 animals were killed for examination on days 0, 1, 3, 7, 14, 21, and 28.
Gen'i Murasaki, Yukitada Miyata, Tomoyuki Shirai, Masayuki Arai, Takashi Kawachi, Nobuyuki Ito   +5 more
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Photophysics of norharmane in micellar environments: a fluorometric study

Biophysical Chemistry, 2004
Steady state photophysics of norharmane (NHM) has been studied in different aqueous micellar environments. In aqueous solution at pH 7, excitation of the neutral species promotes a rapid transfer of proton giving rise to the corresponding cationic emission. Aqueous micelles differing in their surface charge characteristics interact with the fluorophore
Arabinda, Mallick, Nitin, Chattopadhyay
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In vitro and in vivo formation of aminophenylnorharman from norharman and aniline

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2002
Norharman is not mutagenic to Salmonella strains, but becomes so to S. typhimurium TA98 and YG1024 with S9 mix in the presence of the non-mutagenic aromatic amine, aniline. The mutagenicity from norharman and aniline in the presence of S9 mix is reported to be due to formation of a mutagenic compound, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole ...
Yukari, Totsuka, Hiroyuki, Kataoka, Takeji, Takamura-Enya, Takashi, Sugimura, Keiji, Wakabayashi   +4 more
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Norharman and ellipticine: A comparison of their abilities to interact with DNA in vitro

Cancer Letters, 1980
The anti-tumor agent ellipticine has been compared in vitro with the bacterial co-mutagen norharman, a compound which it resembles superfically in chemical structure. Ellipticine was shown to stabilize the structure of double stranded calf-thymus DNA, to induce mutations in strain TA153 of Salmonella tryhimurium and to cause BHK cells to transform ...
J, Ashby, B M, Elliott, J A, Styles
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Norharmane as a potential chemical entity for development of anticancer drugs

European Journal of Medicinal Chemistry, 2019
Cancer is a leading cause of death generally, and to overcome this problem the introduction of a new drug developing is a continuous endeavour. An alkaloid, norharmane and its derivatives, which have anticancer activities, widely distributed in several living and synthetic chemical sources.
Chita Ranjan Sahoo, Sudhir Kumar Paidesetty, Rabindra Nath Padhy   +2 more
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Factors Influencing the Norharman and Harman Contents in Espresso Coffee

Journal of Agricultural and Food Chemistry, 2007
Espresso coffee (EC) brews were analyzed for beta-carboline [norharman (NH) and harman (H)] contents, by RP-HPLC with fluorescence detection. The influence of the coffee species (arabica or robusta), the roast degree, and the brew length was studied.
Rita C, Alves, Susana, Casal, Beatriz P P, Oliveira   +2 more
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Norharman inhibition of [3H]-diazepam binding in mouse brain

Life Sciences, 1981
Abstract Norharman competitively inhibits specific binding of [ 3 H]-diazepam in mouse brain homogenates. In vivo this β-carboline produces a striking rigid catatonic-like appearance which is abolished by diazepam. It also causes a rapid tremor but has little anticonvulsant effect.
A M, Morin, I A, Tanaka, C G, Wasterlain
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Cyclodextrins modify the proton transfer photoreactions of norharmane

Journal of Photochemistry and Photobiology A: Chemistry, 2005
Abstract Excited state proton transfer reactions of norharmane have been investigated in the presence of cyclodextrins (CDs): β-CD and modified β-CDs at pH values of 4.0, 7.8, 10.0 and 13.0. The spectral shape and the species present in the equilibria depend on the CDs and the pH of the media.
José L. Prados, Andrés G. León, Ana I. Olives, M. Antonia Martín, Benito Del Castillo   +4 more
openaire   +1 more source