Results 81 to 90 of about 504 (130)
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The impact of smoking and drinking on plasma levels of norharman
European Neuropsychopharmacology, 2002The hypothesized role of the beta-carboline norharman in processes of drug dependence forms the basis for several studies on plasma levels of norharman among substance-using populations, particularly among alcoholics and smokers. However, it is not clear whether norharman is implicated in processes of dependence to both substances, or only to tobacco ...
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exaly +6 more sources
Tryptophan: a precursor for the endogenous synthesis of norharman in man
Neuroscience Letters, 2001We investigated whether in healthy subjects L-tryptophan may serve as a precursor for the endogenous synthesis of the beta-carboline norharman. For this purpose subjects, smokers as well as non-smokers, received 0 or 1.2 g of an oral dose of tryptophan. Smokers started the experiment 2 h after cessation of smoking.
Durk Fekkes +2 more
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Norharman and anxiety disorders
Acta Neuropsychiatrica, 1996SummaryNorharman is a ß-carboline, possibly of endogenous origin, although cigarette smoking and food are sources too. In brain specific binding sites have been demonstrated. In higher doses norharman binds to benzodiazepine receptors and has MAO-B inhibitory activity.
L, Pepplinkhuizen +2 more
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Photochemistry of norharmane in aqueous solution
Photochemical & Photobiological Sciences, 2009The photochemistry of norharmane (9H-pyrido[3,4-b]indole) in acidic (pH 5.0+/-0.1) and alkaline (pH 10.0+/-0.1) aqueous solutions was studied. The photochemical reactions were monitored by TLC, UV/VIS absorption spectroscopy, high-performance liquid chromatography (HPLC), electronic ionization-mass spectrometry (EI-MS), UV-laser desorption/ionization ...
M Micaela, Gonzalez +4 more
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Comutagenic effect of norharman with aminopyridine derivatives
Mutation Research Letters, 1982The mutagenicities of 3 monoaminopyridines, 4 methyl-substituted monoaminopyridines and 3 diaminopyridines were tested with or without norharman in the Salmonella assay system. None of the compounds was mutagenic without norharman. However, 3-aminopyridine and 2-amino-3-methylpyridine were mutagenic in the presence of norharman and S9 mix; 3 ...
K, Wakabayashi +3 more
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Effect of norharman on the mutagenicity of toluidine metabolites
Toxicology Letters, 1989Among the different metabolites of o-toluidine only the nitroso and hydroxylamino derivatives were found to be very potent frameshift mutagens in the presence of the co-mutagen norharman and S9. In the absence of norharman and S9 they are only base pair mutagens.
R L, Gupta +4 more
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Photochemical and sonochemical reactions of norharmane
Journal of Photochemistry and Photobiology A: Chemistry, 1996In this work, a study on the photochemical and sonochemical behaviour of norharmane in halomethane media (dichloromethane, chloroform, carbon tetrachloride and dibromomethane) is presented. When solutions of norharmane in these media are irradiated with UV light or sonicated with ultrasound at 20 or 50 kHz, the cationic species of norharmane appears in
D. Reyman +3 more
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Norharman and alcohol-dependency in male Wistar rats
European Neuropsychopharmacology, 2002We examined the effects of ethanol ingestion to rats on levels of the beta-carboline norharman in plasma, brain and liver at the end of ethanol ingestion and 10 h after withdrawal. We also investigated the effect of exogenously administered norharman on the behavioural signs of alcohol withdrawal.
Fekkes, Durk +2 more
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Chronic effects of norharman in rats treated with aniline
Toxicology Letters, 1980The carcinogenic effects of aniline and norharman given alone or in combination were examined in rats. Neoplastic changes including hyperplastic changes of the urinary bladder were not found in all groups. Papillomas of forestomach were observed in 5 rats out of 110 rats. However, this was not significantly different among the groups. Pyelonephritis or
A, Hagiwara +5 more
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Mutagenicities of mono-nitrobenzene derivatives in the presence of norharman
Mutation Research Letters, 1983The mutagenicities of 22 mono-nitrobenzene derivatives, i.e., nitrobenzene [98-95-3] and the ortho, meta and para isomers of nitrotoluene [88-72-2, 99-08-1, 99-99-0], nitrophenol [88-75-5, 554-84-7, 100-02-7], nitroanisole [91-23-6, 555-03-3, 100-17-4], nitrochlorobenzene [88-73-3, 121-73-3, 100-00-5], nitrobenzoic acid [552-16-9, 121-92-6, 62-23-7 ...
J, Suzuki, T, Koyama, S, Suzuki
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