Results 81 to 90 of about 890 (147)

Norharman-induced motoric impairment in mice: Neurodegeneration and glial activation in substantia nigra

, 2006
The beta-carboline norharman is present in cooked food and tobacco smoke and show structural resemblance to the neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Fredriksson, Anders,, Brittebo, Eva B,, Östergren, Anna,   +2 more
core   +1 more source

Oxidative metabolism of the bioactive and naturally occurring β-carboline alkaloids, norharman and harman, by human cytochrome P450 enzymes

, 2013
Norharman and harman are naturally occurring β-carboline alkaloids exhibiting a wide range of biological, psychopharmacological, and toxicological actions. They occur in foods and tobacco smoke and also appear endogenously in humans.
Herraiz, Tomás, Guillén, Hugo, Arán, Vicente J.   +2 more
core   +1 more source

The role of norhaman in alcohol dependence and smoking

, 2005
Item does not contain fulltextThe aim of this study was to investigate the role of the endogenous substance norharman in processes of alcohol and nicotine or tobacco dependence in both humans and animals.
Bongers, I.M.B., Spijkerman, R., Fekkes, D., van den Eijnden, R.J.J.M., Bongers, I.M.B.; id_orcid, Eijnden, R.J.J.M. van den, Spijkerman, R, Eijnden, R, Bongers, IL (Ilja), Fekkes, Durk   +9 more
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Effect of different types of sugars in a marinating formulation on the formation of heterocyclic amines in grilled chicken [PDF]

, 2014
The aim of the study was to determine the effect of different types of sugar on the formation of heterocyclic amines (HCA) in marinated grilled chicken. Chicken breast samples were marinated with table sugar, brown sugar, and honey for 24 h at 4 °C.
Selamat, Jinap, Hasnol, Nur Diyana Syamim, Sanny, Maimunah   +2 more
core   +1 more source

Inhibitory effects of grape seed extract on the formation of heterocyclic aromatic amines in beef and chicken meatballs cooked by different techniques [PDF]

, 2017
Heterocyclic aromatic amines (HCAs) are mutagenic compounds formed when foods are cooked at high temperatures. The objective of this study was to examine the efficiency of the grape seed extract (GSE) on the formation of HACs in beef and chicken ...
Uren, Ali, Hasan Keskekoglu, Keskekoglu, Hasan, Ali Uren   +3 more
core   +1 more source

Contribution of Harman and Norharman to the Reinforcing Efficacy of Aqueous Tobacco Smoke Extract Self-Administered by Rats

, 2012
Background: Animal models of drug abuse treat nicotine as the primary reinforcing agent that promotes tobacco addiction. However, rodents demonstrate poor self-administration of nicotine despite evidence of tobacco's high abuse potential in humans.
Crowther, Alex John (11688232), null null, Alex John Crowther   +2 more
core   +1 more source

Farklı Gün Uygulamalarının Bazı Siyanobakterilerde Norharman Üretimi Üzerine Etkisi

, 2016
Siyanobakteriler, metabolizmalarından ötürü biyolojik, ekolojik ve ekonomik bakımdan önemli bakterilerdir. Özellikle çeşitli olumsuz şartlarda üretilmiş ve her biri özelleşmiş fonksiyonlara sahip bir dizi sekonder metabolit içerirler.
İnanç Baral, Zekeriya Altuner, Tünay Karan, Taner Daştan   +3 more
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Inhibition of monoamine oxidase by the tryptophan derivatives harman and norharman which are present in tobacco smoke: A possible explanation for the lower incidence of Parkinson´s disease in smokers

, 2008
Titeldatei Einleitung Materialien und Methoden Ergebnisse Diskussion Fazit, Zusammenfassung und Methodikanhang LiteraturverzeichnisEpidemiologische Studien zeigen, dass Tabakraucher eine verminderte Inzidenz der Parkinson´schen Krankheit ...
Meier-Henco, Mignon Lesly
core   +1 more source

Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain : Role of Neuromelanin and Cytochrome P450 for Toxicity

, 2005
The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and ...
Östergren, Anna
core   +2 more sources

Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents

, 2011
Monoamine oxidase (MAO) enzymes catalyze the oxidative deamination of amines and neurotransmitters and inhibitors of MAO are useful as neuroprotectants. This work evaluates the human MAO-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Herraiz Tomico, Tomás, Tomás Herraiz
core   +1 more source