Results 61 to 70 of about 890 (147)

Recent Perspectives on Meat Consumption and Cancer Proliferation

Journal of Food Processing and Preservation, Volume 2025, Issue 1, 2025.
Red and processed meat consumption has been associated with a higher risk of developing several types of cancer such as colorectal, prostate, breast, lung, and pancreatic cancers according to a recent investigation by multiple in vivo and in vitro studies.
Ushna Momal, Hammad Naeem, Farhan Aslam, Muhammad Shahbaz, Muhammad Imran, Muzzamal Hussain, Awais Ahmad, Anjuman Gul Memon, Ahmed Mujtaba, Muhammad Atif, Tahir Mehmood, Tadesse Fenta Yehuala, Essam Hebishy   +12 more
wiley   +1 more source

Effects of harman and norharman on the mutagenicity and binding to DNA of benzo[a]pyrene metabolites in vitro and on aryl hydrocarbon hydroxylase induction in cell culture

, 1977
Harman and norharman, two β-carboline derivatives known to exist in certain foods and to be formed during pyrolysis of tobacco and meat, were tested for mutagenic activity in the presence of benzo[a]pyrene, mouse liver enzymes, and Salmonella typhimurium
Pelkonen, Olavi, Nebert, Daniel W, Legraverend, Catherine, Levitt, Roy C   +3 more
core   +1 more source

Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain [Elektronisk resurs] : Role of Neuromelanin and Cytochrome P450 for Toxicity

, 2005
The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and ...
Lindquist, Nils Gunnar, Tjälve, Hans,, Svensson, Anne-Lie, Brittebo, Eva, Östergren, Anna,   +4 more
core   +5 more sources

Mechanism of action of “cistanche deserticola–Polygala” in treating Alzheimer's disease based on network pharmacology methods and molecular docking analysis

IET Systems Biology, Volume 18, Issue 6, Page 271-284, December 2024.
Differential expression of genes between AD patients and the normal population (a) Basic information of GSE5281 dataset. AD patient samples were labelled with green, while control group samples were labelled with purple. (b) Uniform manifold approximation and projection(UMAP) of differentially expressed gene (DEG) in GSE5281. (c) Expression density map
Shaoqiang Wang, Yifan Wang
wiley   +1 more source

Differential effects of dopamine melanin on norharman-induced toxicity in PC12 cells

, 2007
The food contaminant norharman structurally resembles MPTP a compound that selectively damages pigmented brain areas. Both compounds are sequestered and retained in melanin-containing neurons.
Lindquist, Nils Gunnar,, Brittebo, Eva B.,, Östergren, Anna,   +2 more
core   +1 more source

Integration of pharmacochemistry, pharmacodynamics and metabolomics to reveal active ingredients and mechanism of Nan Bao detox capsule alleviating methamphetamine addiction

Addiction Biology, Volume 29, Issue 11, November 2024.
Experimental flowchart: NBDC is composed of various medicinal materials such as ginseng, astragalus and polygala. UPLC‐MS is used to analyse the components of NBDC. MA addiction rats is administered with NBDC. Blood samples are subjected to metabolomic analysis.
Bin Zhang, Chen Yang, Yuxiao Zheng, Xinliang Li, Xingguo Wang, Li Yuehui   +5 more
wiley   +1 more source

The total ion current (TIC) of harman and norharman extracted from MM (pink) and LB (black) post-incubation media.

, 2018
The total ion current (TIC) of harman and norharman extracted from MM (pink) and LB (black) post-incubation media.
Anna Katarzyna Wrońska (4922722), Agata Kaczmarek (4922719), Mieczysława Irena Boguś (4922725), Michalina Kazek (4922728)   +3 more
core   +1 more source

Comparing application methods of reishi mushroom (Ganoderma lucidum) extract in deep‐fried meatballs: impact on heterocyclic aromatic amine formation

Journal of the Science of Food and Agriculture, Volume 104, Issue 10, Page 5826-5833, 15 August 2024.
Abstract BACKGROUND The present research was conducted to investigate the impact of reishi mushroom extract (RME) on the formation of heterocyclic aromatic amines (HAAs) in meatballs. Sample preparations involved applying RME using either the spreading or addition method, with varying concentrations (0%, 0.25%, 0.5%, and 1% of RME), followed by deep ...
Bengu Guzel, Damla Gumus, Mevlude Kizil
wiley   +1 more source

Monoamine oxidase inhibitory activity in tobacco particulate matter: Are harman and norharman the only physiologically relevant inhibitors?

, 2019
Monoamine oxidase inhibition is significant in smokers, but it is still unclear how the inhibition that is seen in the brains and bodies of smokers is brought about. Our aim was to test the contribution of the harman and norharman in tobacco smoke to MAO-
Katharine A. Brennan (6651969), Penelope Truman (6651966), Peter Grounds (6651968)   +2 more
core   +1 more source

Bitter melon extract mitigates heterocyclic aromatic amine formation in chicken thigh meat

Food Science &Nutrition, Volume 12, Issue 6, Page 4259-4268, June 2024.
The impact of bitter melon extract (BME) on heterocyclic aromatic amine (HAA) formation in chicken thigh meat during pan‐frying at various temperatures has been investigated. Higher cooking temperatures led to increased total HAA levels, while marination with BME significantly mitigated HAA formation, demonstrating reductions ranging from 25.9% to 69.9%
Damla Gumus, Arife Macit, Bengu Guzel, M. Merve Tengilimoglu‐Metin, Mevlude Kizil   +4 more
wiley   +1 more source