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Identification of reactive carbonyl species as key inducers of harman and norharman formation in meat products: Insights from chemical model systems of tryptophan and myofibrillar protein

open access: yes
Harman and norharman are carcinogenic β-carboline heterocyclic amines (HAs) formed during meat thermal processing. In the initial phase of this study, we hypothesized that reactive carbonyl species (RCSs) drive their formation via the Pictet-Spengler ...
Minquan Xia   +8 more
core   +1 more source

Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain : Role of Neuromelanin and Cytochrome P450 for Toxicity

open access: yes, 2005
The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and ...
Östergren, Anna
core   +2 more sources

Comutagenic Action of Norharman and Harman

open access: yesProceedings of the Japan Academy, 1977
NAGAO, Minako   +8 more
openaire   +2 more sources

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