Results 1 to 10 of about 671,109 (238)

Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration

eLife, 2020
Neuronal degeneration in the zebrafish retina stimulates Müller glia (MG) to proliferate and generate multipotent progenitors for retinal repair. Controlling this proliferation is critical to successful regeneration.
Mi-Sun Lee, Jin Wan, Daniel Goldman
doaj   +1 more source

Mechanisms of Notch signaling: a simple logic deployed in time and space

Development, 2019
Most cells in our body communicate during development and throughout life via Notch receptors and their ligands. Notch receptors relay information from the cell surface to the genome via a very simple mechanism, yet Notch plays multiple roles in ...
D. Henrique, F. Schweisguth
semanticscholar   +1 more source

Notch Filtering Suitable for Real Time Removal of Power Line Interference [PDF]

, 2013
This paper presents a high performance notch filtering for real time suppression of power line interference in a general signal. The disturbing signal is suppressed using an optimal notch FIR filter with tunable notch frequency.
Vlcek, M., Zahradnik, P.
core   +1 more source

Emerging structures and dynamic mechanisms of γ-secretase for Alzheimer’s disease

Neural Regeneration Research
γ-Secretase, called “the proteasome of the membrane,” is a membrane-embedded protease complex that cleaves 150+ peptide substrates with central roles in biology and medicine, including amyloid precursor protein and the Notch family of cell-surface ...
Yinglong Miao, Michael S. Wolfe
doaj   +1 more source

Fatigue life prediction of titanium alloy TA19 based on Weibull distribution and first-order reliability correction

Cailiao gongcheng
With the improvement in aeroengine performance，critical components （such as centrifugal impellers） operate under high-temperature，high-stress，and complex load conditions.
QUAN Changbiao, LIAO Mingfu, LI Jian, TANG Xiuzhi, HUANG Jia, QIN Houjun   +5 more
doaj   +1 more source

Critical Distance Default Values for Structural Steels and a Simple Formulation to Estimate the Apparent Fracture Toughness in U-Notched Conditions

Metals, 2018
The structural integrity assessment of components containing notch-type defects has been the subject of extensive research in the last few decades. The assumption that notches behave as cracks is generally too conservative, making it necessary to develop
Sergio Cicero, Juan Diego Fuentes, Isabela Procopio, Virginia Madrazo, Pablo González   +4 more
doaj   +1 more source

An Extended Finite Element Method (XFEM) Study on the Elastic T-Stress Evaluations for a Notch in a Pipe Steel Exposed to Internal Pressure

Mathematics, 2021
The work investigates the importance of the K-T approach in the modelling of pressure cracked structures. T-stress is the constant in the second term of the Williams expression; it is often negligible, but recent literature has shown that there are cases
Khadija Yakoubi, Soufiane Montassir, Hassane Moustabchir, Ahmed Elkhalfi, Catalin Iulian Pruncu, Jamal Arbaoui, Muhammad Umar Farooq   +6 more
doaj   +1 more source

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Science Translational Medicine, 2018
Aberrant hepatocyte Notch activation is required for development of NASH-associated fibrosis, and Notch inhibition ameliorates obesity-induced liver disease.
Changyu Zhu, KyeongJin Kim, Xiaobo Wang, Alberto Bartolomé, M. Salomao, P. Dongiovanni, M. Meroni, M. Graham, Katherine P. Yates, A. Diehl, R. Schwabe, I. Tabas, Luca Valenti, J. Lavine, U. Pajvani   +14 more
semanticscholar   +1 more source

Macrophage Notch1 Participates in LPS-Induced Acute Lung Injury via Regulating CCR5 Expression in Mice

Frontiers in Bioscience-Landmark
Background: As pivotal immunoregulatory sentinels in pulmonary defense systems, alveolar macrophages (AMs) play dual roles in mediating inflammatory responses and tissue repair processes during various phases of inflammatory cascades ...
Ruiyu Zhang, Hui Du, Zhi Liu, Yuxi Lei, Huizhi Hu, Junwen Zheng, Pu Yang, Dongchi Zhao   +7 more
doaj   +1 more source

Low-Noise Chopper-Stabilized Multi-Path Operational Amplifier with Nested Miller Compensation for High-Precision Sensors

Applied Sciences, 2019
This paper presents a low-noise multi-path operational amplifier for high-precision sensors. A chopper stabilization technique is applied to the amplifier to remove offset and flicker noise.
Jaesung Kim, Hyungseup Kim, Kwonsang Han, Donggeun You, Hyunwoo Heo, Yongsu Kwon, Dong-il “Dan” Cho, Hyoungho Ko   +7 more
doaj   +1 more source