Results 41 to 50 of about 671,109 (238)
Frontiers in Immunology, 2018 The Notch pathway plays critical roles in the development and functional modulation of myeloid cells. Previous studies have demonstrated that Notch activation promotes M1 polarization and phagocytosis of macrophages; however, the downstream molecular ...
Yan Lin +13 more
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A crack-like notch analogue for a safe-life fretting fatigue design methodology [PDF]
, 2003 Various analogies have recently been proposed for comparing the stress fields induced in fretting fatigue contact situations, with those of a crack and a sharp or a rounded notch, resulting in a degree of uncertainty over which model is most appropriate ...
Ciavarella, M.
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A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss [PDF]
, 2016 Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we identified a missense mutation in ...
Cabrera Serrano, Macarena +5 more
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Notch signaling and Notch signaling modifiers [PDF]
The International Journal of Biochemistry & Cell Biology, 2011 Originally discovered nearly a century ago, the Notch signaling pathway is critical for virtually all developmental programs and modulates an astounding variety of pathogenic processes. The DSL (Delta, Serrate, LAG-2 family) proteins have long been considered canonical activators of the core Notch pathway. More recently, a wide and expanding network of
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Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Signal Transduction and Targeted TherapyNotch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution.
Qingmiao Shi +9 more
semanticscholar +1 more source
Analysis of Various Chevron Notch Types and its Influence on the Ligament Area [PDF]
, 2019 Specimens for the bending tests with the chevron notch are standardized for the evaluation of the fracture toughness of various materials. In this contribution a difference of the ligament area of the specimens with the straight through notch and the
Miarka, Petr +3 more
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eLife, 2016 Drosophila hematopoiesis bears striking resemblance with that of vertebrates, both in the context of distinct phases and the signaling molecules. Even though, there has been no evidence of Hematopoietic stem cells (HSCs) in Drosophila, the larval lymph ...
Nidhi Sharma Dey +4 more
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Intratumoral heterogeneity generated by Notch signaling promotes small cell lung cancer
Nature, 2017 The Notch signalling pathway mediates cell fate decisions and is tumour suppressive or oncogenic depending on the context. During lung development, Notch pathway activation inhibits the differentiation of precursor cells to a neuroendocrine fate.
Jing S. Lim +19 more
semanticscholar +1 more source
Active control of vibrant actuators with adaptive adjustment of the reference [PDF]
, 1999 An improved adaptive filter for eliminating periodic vibrations of unknown frequency in rotary machinery is presented. The proposed canceller is based on a usual bank of digital adaptive notch filters, each filter tuned in the cancellation of one ...
Bertran Albertí, Eduardo +1 more
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Notch one for activating NOTCH [PDF]
Science-Business eXchange, 2011 Vanderbilt researchers have identified downregulation of NOTCH signaling as a mechanism tumors use to evade the immune system, suggesting that restoring activation of the pathway could improve cancer immunotherapy. Researchers have been split on whether it is better to up- or downregulate NOTCH.
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