Results 51 to 60 of about 671,109 (238)

Cathepsin C-driven enhancement of neutrophil extracellular trap formation contributes to acute lung injury

iScience
Summary: Acute lung injury (ALI) is a severe pulmonary inflammatory disease with high morbidity and mortality rates. The pulmonary inflammatory phenotype of ALI is driven by the excessive aggregation and activation of neutrophils, triggering a cytokine ...
Xinyu Wu, Huijun Liu, Qingwu Qin, Lin Yuan, Ye Yao, Xizi Du, Qiuyan Qin, Leyuan Wang, Qianyu Zhao, Ling Qin, Yang Xiang, Ming Yang, Xiaoqun Qin, Chi Liu   +13 more
doaj   +1 more source

Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis

Frontiers in Cell and Developmental Biology, 2022
Organ development, homeostasis, and repair often rely on bidirectional, self-organized cell-niche interactions, through which cells select cell fate, such as stem cell self-renewal and differentiation.
Chin-Lin Guo
doaj   +1 more source

Notch signaling during human T cell development [PDF]

, 2012
Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy, A Krueger, A Sambandam, A Wilson, A Wolfer, AC Jaleco, AI Garbe, AP Weng, B Blom, B Reizis, B Vandekerckhove, BN Weber, C Benne, CC Tydell, CN Ting, D Hockemeyer, D Hockemeyer, E Robey, EM Six, ES David-Fung, F Klein, F Radtke, F Radtke, F Timmermans, F Weerkamp, F Weerkamp, G Awong, H Hirata, H Neves, H Wang, HT Petrie, HY Kueh, I Hoebeke, I Maillard, I Maillard, I Walle Van de, I Walle Van de, J Buer, J Gotter, J Plum, J Shi, JS Yuan, K Heinzel, K Hozumi, K Li, K Maki, K Tanigaki, L Li, M Ciofani, M Ciofani, M Ciofani, M Garcia-Peydro, M Ghisi, M Magri, M Smedt De, M Smedt De, M Smedt De, M Smedt De, MA Yui, MD Green, ML Joachims, N Lefort, P Beatus, P Doerfler, P Li, QL Hao, QL Hao, R Haddad, RN Motte-Mohs La, S Coppernolle Van, S Doulatov, S Gonzalez-Garcia, S Suliman, S Verbeek, SK Durum, SK Ye, SM Lehar, SY Lee, T Hosoya, T Ikawa, T Ikawa, T Kreslavsky, T Kreslavsky, T Palomero, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, TB Feyerabend, TM Schmitt, TN Taghon, W Dontje, WA Dik, Y Wu, YR Carrasco, Z Galic   +97 more
core   +2 more sources

Notch and Hedgehog Signalling Axis Drive Senescence in HER2-Positive Breast Cancer Resistant to Trastuzumab

European Journal of Biology
Objective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, remains a significant ...
Asiye Büşra Boz Er, İdris Er
doaj   +1 more source

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]

, 2018
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana, Campese, Antonio Francesco, Felli, MARIA PIA, Ferrandino, Francesca, Grazioli, Paola, Screpanti, Isabella   +5 more
core   +2 more sources

Notch signalling in T cells: bridging tumour immunity and intratumoral cellular crosstalk

Frontiers in Immunology
BackgroundNotch receptor–ligand interaction is ubiquitous and fundamental for coordinating cellular differentiation and determining cell fate for the development of various tissues and organs.
Jasmine Sultana, Pritha Roy Choudhury, Saurav Bera, Mohona Chakravarti, Aishwarya Guha, Prodipto Das, Juhina Das, Gayatri S Iyer, Anirban Sarkar, Sukanya Dhar, Nilanjan Ganguly, Rathindranath Baral, Anamika Bose, Saptak Banerjee   +13 more
doaj   +1 more source

The Effect of Numerical 2D and 3D Fem Element Modelling on Strain and Stress Distributions at Laser Weld Notches in Steel Sandwich Type Panels

Polish Maritime Research, 2018
Like other means of transport, merchant ships face the problem of increasing requirements concerning the environment protection, which, among other issues, implies the reduction of fuel consumption by the ship.
Niklas Karol, Kozak Janusz
doaj   +1 more source

Research progress in the roles of Notch signaling pathway during fracture healing

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur.
GUO Liqiang, ZHAO Shitian, SHU Bing
doaj   +1 more source

Suppression of Second-Order Harmonic Current for Droop-Controlled Distributed Energy Resource Converters in DC Microgrids [PDF]

, 2020
Droop-controlled distributed energy resource converters in dc microgrids usually show low output impedances. When coupled with ac systems, second-order harmonics typically appear on the dc-bus voltage, causing significant harmonic currents at the ...
Caldognetto, Tommaso, Liu, Guangyuan, Magnone, Paolo, Mattavelli, Paolo   +3 more
core   +1 more source

Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics

npj Systems Biology and Applications
Engineered T cells have emerged as highly effective treatments for hematological cancers. Hundreds of clinical programs are underway in efforts to expand the efficacy, safety, and applications of this immuno-therapeutic modality.
Daniel C. Kirouac, Cole Zmurchok, Denise Morris   +2 more
doaj   +1 more source