Results 1 to 10 of about 2,524,732 (339)

Engineering of an enhanced synthetic Notch receptor by reducing ligand-independent activation. [PDF]

Commun Biol, 2020
Notch signaling is highly conserved in most animals and plays critical roles during neurogenesis as well as embryonic development. Synthetic Notch-based systems, modeled from Notch receptors, have been developed to sense and respond to a specific ...
Yang ZJ, Yu ZY, Cai YM, Du RR, Cai L.
europepmc   +2 more sources

A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers. [PDF]

PLoS Computational Biology, 2023
All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the Notch signal
Daipeng Chen, Zary Forghany, Xinxin Liu, Haijiang Wang, Roeland M H Merks, David A Baker   +5 more
doaj   +2 more sources

Ubiquitylation is required for the incorporation of the Notch receptor into intraluminal vesicles to prevent prolonged and ligand-independent activation of the pathway [PDF]

BMC Biology, 2022
Background Ubiquitylation of the ligands and the receptor plays an important part in the regulation of the activity of the evolutionary conserved Notch signalling pathway.
Björn Schnute, Hideyuki Shimizu, Marvin Lyga, Martin Baron, Thomas Klein   +4 more
doaj   +2 more sources

Prognostic roles of Notch receptor mRNA expression in human ovarian cancer. [PDF]

Oncotarget, 2017
Aberrant activation of Notch signaling pathway has been correlated with high grade ovarian carcinoma and carcinogenesis. However, the predictive and prognostic values of Notch signaling pathway in ovarian cancer patients remains unclear.
Chen C, Wang X, Huang S, Wang L, Han L, Yu S.   +5 more
europepmc   +2 more sources

Prognostic values of four Notch receptor mRNA expression in gastric cancer. [PDF]

Sci Rep, 2016
Notch ligands and receptors are frequently deregulated in several human malignancies including gastric cancer. The activation of Notch signaling has been reported to contribute to gastric carcinogenesis and progression.
Wu X, Liu W, Tang D, Xiao H, Wu Z, Chen C, Yao X, Liu F, Li G.   +8 more
europepmc   +2 more sources

In vivo analysis of the Notch receptor S1 cleavage.

PLoS ONE, 2009
A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface.
Robert J Lake, Lisa M Grimm, Alexey Veraksa, Andrew Banos, Spyros Artavanis-Tsakonas   +4 more
doaj   +2 more sources

Notch receptor expression in neurogenic regions of the adult zebrafish brain. [PDF]

PLoS ONE, 2013
The adult zebrash brain has a remarkable constitutive neurogenic capacity. The regulation and maintenance of its adult neurogenic niches are poorly understood.
Vanessa de Oliveira-Carlos, Julia Ganz, Stefan Hans, Jan Kaslin, Michael Brand, Michael Brand   +5 more
doaj   +2 more sources

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Signal Transduction and Targeted Therapy
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution.
Qingmiao Shi, Chen Xue, Yifan Zeng, Xin Yuan, Qingfei Chu, Shuwen Jiang, Jinzhi Wang, Yaqi Zhang, Danhua Zhu, Lanjuan Li   +9 more
doaj   +2 more sources

Development of an optimized synthetic Notch receptor as an in vivo cell-cell contact sensor. [PDF]

Proc Natl Acad Sci U S A, 2017
He L, Huang J, Perrimon N.
europepmc   +2 more sources

Control of transcriptional activity by design of charge patterning in the intrinsically disordered RAM region of the Notch receptor. [PDF]

Proc Natl Acad Sci U S A, 2017
Sherry KP, Das RK, Pappu RV, Barrick D.
europepmc   +2 more sources