Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand. [PDF]
PLoS ONE, 2016 Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated
Maxwell Greene +5 more
doaj +4 more sources
The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking. [PDF]
Elife, 2018 Li B +6 more
europepmc +2 more sources
The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation [PDF]
Biomolecules, 2021 Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limited ...
Judith Hounjet, Marc Vooijs
doaj +4 more sources
A new model of Notch signaling: Control of Notch receptor cis-inhibition via Notch ligand dimers [PDF]
PLOS Computational Biology, 2022 AbstractAll tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the Notch signal transduction pathway, a ubiquitous signalling system found in the vast majority of metazoan
Daipeng Chen +5 more
openalex +6 more sources
Notch Receptor Activation Inhibits Oligodendrocyte Differentiation [PDF]
Neuron, 1998 In this study, we show that oligodendrocyte differentiation is powerfully inhibited by activation of the Notch pathway. Oligodendrocytes and their precursors in the developing rat optic nerve express Notch1 receptors and, at the same time, retinal ganglion cells express Jagged1, a ligand of the Notch1 receptor, along their axons.
Songli Wang +7 more
semanticscholar +3 more sources
Diversity in Notch ligand-receptor signaling interactions [PDF]
eLife, 2023 Abstract The Notch signaling pathway uses families of ligands and receptors to transmit signals to nearby cells. These components are expressed in diverse combinations in different cell types, interact in a many-to-many fashion, both within the same cell (in cis) and between cells (in trans), and their interactions are modulated by ...
Rachael Kuintzle +2 more
openalex +5 more sources
Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling [PDF]
Journal of Cell Biology, 2015 Notch family members are transmembrane receptors that mediate essential developmental programs. Upon ligand binding, a proteolytic event releases the intracellular domain of Notch, which translocates to the nucleus to regulate gene transcription. In addition, Notch trafficking across the endolysosomal system is critical in its regulation. In this study
Haiying Li +13 more
openalex +8 more sources
Cancer-associated Notch receptor variants lead to O-fucosylation defects that deregulate Notch signaling. [PDF]
J Biol Chem, 2022 NOTCH1 is a transmembrane receptor that initiates a signaling pathway involved in embryonic development of adult tissue homeostasis. The extracellular domain of NOTCH1 is composed largely of epidermal growth factor-like repeats (EGFs), many of which can be O-fucosylated at a specific consensus sequence by protein O-fucosyltransferase 1 (POFUT1).
Pennarubia F +3 more
europepmc +3 more sources
Notch receptor and Notch ligand expression in developing avian cartilage [PDF]
Journal of Anatomy, 2009 AbstractThe development of limb cartilage involves complex signalling pathways allowing the formation of distinct segments of cartilage that are maintained in the fully developed joint. In this study, we investigated the Notch signalling pathway and its role in cartilage development.
Rebecca Williams +4 more
semanticscholar +3 more sources