Results 31 to 40 of about 2,524,732 (339)
Notching tumor: Signaling through Notch receptors improves antitumor T cell immunity [PDF]
OncoImmunology, 2016 Notch signaling is crucial for lymphocyte effector and memory differentiation. While tumor suppress Notch signaling in antitumor lymphocytes, recent studies show that the pharmacological Delta-like ligand-1 multivalent cluster or proteasome inhibitor bortezomib can restore Notch-NF-κB signaling in T cells of tumor-bearing hosts with a potential to ...
Roman, Uzhachenko, Anil, Shanker
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A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells
Frontiers in Immunology, 2018 The Notch receptor is an evolutionarily highly conserved transmembrane protein essential to a wide spectrum of cellular systems, and its deregulation has been linked to a vast number of developmental disorders and malignancies.
Martin Peter Steinbuck, Susan Winandy
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Nuclear receptor regulation gears up another Notch [PDF]
Nuclear Receptor Signaling, 2006 In this perspective we describe examples of crosstalk between nuclear receptors (NRs) and Notch signaling by means of direct functional interactions between components of both pathways. This crosstalk may provide eukaryotic organisms with molecular mechanisms for the coordination of llong-distance endocrine signals with cell-to-cell juxtacrine ...
Belandia, Borja, Parker, Malcolm G.
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The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. [PDF]
PLoS Biology, 2010 Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble ...
Julien Moretti +8 more
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The NOTCH receptor and its ligands
Trends in Cell Biology, 1997 An intricate interplay of signalling pathways dictates the acquisition of specific cell fates during development. The NOTCH receptor is the central element in a cell-interaction mechanism that controls the fate of a very broad spectrum of precursor cells.
R J, Fleming +2 more
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Frontiers in Physiology, 2020 Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides regulating cell-fate decisions at an individual cell level, Notch signaling coordinates the emergent spatiotemporal patterning in a tissue through ligand-receptor ...
Federico Bocci +5 more
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Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells
Cells, 2019 Bone morphogenetic protein (BMP) and Notch signaling are critical for endothelial cell (EC) differentiation in vascular development. Recent studies have shown that excess BMP activity induces Notch signaling in cerebral ECs resulting in arteriovenous ...
Xiuju Wu +8 more
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Therapeutic antibody targeting of individual Notch receptors [PDF]
Nature, 2010 The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to regulate cell fate and growth. Ligand binding triggers a conformational change in the receptor negative regulatory region (NRR) that enables ADAM protease cleavage at a juxtamembrane site that ...
Yan, Wu +23 more
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Competition in notch signaling with cis enriches cell fate decisions.
PLoS ONE, 2014 Notch signaling is involved in cell fate choices during the embryonic development of Metazoa. Commonly, Notch signaling arises from the binding of the Notch receptor to its ligands in adjacent cells driving cell-to-cell communication.
Pau Formosa-Jordan, Marta Ibañes
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Neoplasia, 2014 Elevated Notch ligand and receptor expression has been associated with aggressive forms of prostate cancer, suggesting a role for Notch signaling in regulation of prostate tumor initiation and progression.
Shubing Zhang +4 more
semanticscholar +1 more source