Results 41 to 50 of about 2,524,732 (339)
Cis-interactions between Notch and its ligands block ligand-independent Notch activity
eLife, 2014 The Notch pathway is integrated into numerous developmental processes and therefore is fine-tuned on many levels, including receptor production, endocytosis, and degradation. Notch is further characterized by a twofold relationship with its Delta-Serrate
William Hunt Palmer +2 more
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Notch mRNA expression in Drosophila embryos is negatively regulated at the level of mRNA 3' processing. [PDF]
PLoS ONE, 2009 Notch receptor regulates differentiation of almost all tissues and organs during animal development. Many mechanisms function at the protein level to finely regulate Notch activity.
Andrew K Shepherd +2 more
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Notch receptors in GtoPdb v.2021.2
IUPHAR/BPS Guide to Pharmacology CITE, 2021 Aberrant Notch signalling is implicated in a number of human cancers [18, 26, 13, 21], and there is intense pharmaceutical activity being directed towards achieving clinically effective Notch pathway inhibition [7, 16].
Christopher Sobey, Thiruma V. Arumugam
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eLife, 2017 Notch is a critical regulator of T cell differentiation and is activated through proteolytic cleavage in response to ligand engagement. Using murine myelin-reactive CD4 T cells, we demonstrate that proximal T cell signaling modulates Notch activation by ...
Graham J Britton +12 more
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CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells
Frontiers in Immunology, 2020 Notch signaling provides an important cue in the mammalian developmental process. It is a key player in T cell development and function. Notch ligands such as Delta-like ligands (DLL) 1, 3, 4, and JAG1, 2 can impact Notch signaling positively or ...
Ankita Mitra +13 more
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PLoS ONE, 2013 The Notch signaling pathway controls diverse cell-fate specification events throughout development. The versatility of this pathway to influence different aspects of development comes from its multiple levels of regulation.
Nalani Sachan +3 more
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Notch Ligand Binding Assay Using Flow Cytometry
Bio-Protocol, 2017 Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013).
Shweta Varshney, Pamela Stanley
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Estradiol meets Notch signaling in developing neurons
Frontiers in Endocrinology, 2011 The transmembrane receptor Notch, a master developmental regulator, controls gliogenesis, neurogenesis and neurite development in the nervous system.
Maria-Angeles eArevalo +5 more
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The Challenge of Targeting Notch in Hematologic Malignancies
Frontiers in Pediatrics, 2014 Notch signaling can play oncogenic and tumor suppressor roles depending on cell type. Hematologic malignancies encompass a wide range of transformed cells, and consequently the roles of Notch are diverse in these diseases. For example Notch is a potent T
Fiorela N Hernandez Tejada +2 more
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Genes & Development, 1995 We have investigated the functional relationships among three loci that are required for multiple alternative cell fate decisions during adult peripheral neurogenesis in Drosophila: Notch (N), which encodes a transmembrane receptor protein, Suppressor of
A. Bailey, J. Posakony
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