Results 221 to 230 of about 190,719 (307)

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels

Advanced Science, EarlyView.
CGRP interacts with HMEC‐1 by binding to surface receptors, influencing the downstream FAK/AKT/VEGF signaling pathway, and promoting the secretion of ANGPTL4 from vascular endothelial cells into the bone microenvironment. This, in turn, regulates the differentiation of BMSCs into osteoblasts, thus promoting bone formation. ABSTRACT Bone angiogenesis is
Qiong Lu, Qiyue Zheng, Zhaokai Zhou, Yajun Chen, Yun Chen, Wenjie Chen, Jiaojiao Wang, Ren Guo, Ren Wu, Lina Chen   +9 more
wiley   +1 more source

Chronic stress drives ovarian cancer progression via myeloid-derived suppressor cells infiltration and Notch signaling pathway activation. [PDF]

Front Immunol
Rivera-López YA, Torres-Rosado AP, Casiano-Martínez JA, Meléndez-Rodríguez LL, Imad-Hamad R, Hernández-Carrasquillo SM, Rivera-Pérez LM, Ortiz-León M, Torres-Rodríguez OI, Aquino-Acevedo AN, Castillo-Ocampo Y, Duffey G, Pérez-Morales J, Townsend MK, Peres LC, Rodriguez PC, Tworoger SS, Armaiz-Pena GN.   +17 more
europepmc   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Metformin Administration Protects Against Deltoid Tendon Damage Through Activation of Notch Signaling. [PDF]

Imeta
Liu C, Wang R, Xu Y, Liu Q, Li Y, Liu X, Shu H, Gao K, Zheng X, Dong Y, Wang Y, Guo B, Fu L, Zhang B, Zhao L, Jia Z, Sun X.   +16 more
europepmc   +1 more source

Redox Oligomer Assembling Hierarchical Reinforced Framework Cathodes for Ultra‐Stable High‐Performance Zinc‐Ion Batteries

Advanced Science, EarlyView.
Redox phenoxoline‐benzoquinone oligomer has been designed as reinforced concrete framework like freestanding cathodes for high‐performance ZIBs. An optimal specific capacity of 339.5 mAh g−1 was contributed with exceptional retention of 87.5% after 65 000 cycles at 10 A g−1. Flexible energy storage is also demostrated.
Shuang Liu, Yiliang Lai, Yinghang Gao, Weihua Tang   +3 more
wiley   +1 more source

Synergistic Crosstalk of PACAP and Notch Signaling Pathways in Bone Development. [PDF]

Int J Mol Sci
Szegeczki V, Pálfi A, Fillér C, Hinnah B, Tóth A, Kovács LS, Jüngling A, Zákány R, Reglődi D, Juhász T.   +9 more
europepmc   +1 more source

Ultrasoft Yet Tough Multifunctional Organohydrogels Enabled by Molecular Chain Lubrication Strategy for Self‐Powered Wearable Electronics

Advanced Science, EarlyView.
An ultrasoft yet tough organohydrogel (AQGL) with 5800% stretchability and 14.3 kPa modulus is developed via a novel molecular chain lubrication strategy. It features optical transparency, drying/freezing (−40°C) tolerance, antibacterial activity, conductivity, self‐healing, and adhesiveness.
Si Wang, Lin Hu, Mingbo Pu, Mingfeng Xu, Tao Zhou, Hanbing Rao, Xiong Li, Xiaoliang Ma, Gehong Su, Xiangang Luo   +9 more
wiley   +1 more source

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, EarlyView.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma. [PDF]

Signal Transduct Target Ther
Li C, Wu P, Xie X, Chen X, Chen L, Zhu L, Xuan Z, Liu T, Tan W, Zhang S, Lin D, Wu C.   +11 more
europepmc   +1 more source

Beyond Cartilage‐Inspired Supramolecular Polyurethane for Adaptive Impact‐Resistant Protection with Robustness, Self‐Healing, and Recyclability

Advanced Science, EarlyView.
Cartilage‐inspired supramolecular polyurethane–urea (PU‐BAMB) elastomers are developed by integrating hierarchical hydrogen bonding and π–π stacking interactions within a dynamically reconfigurable network. This synergistic supramolecular architecture overcomes the intrinsic trade‐off between rigidity and recoverability, imparting exceptional toughness,
Rou‐Han Lai, Chia‐An Chiu, Yi‐An Chen, Athis Watwiangkham, Yu‐Hung Cheng, Yan‐Heng Chen, Min‐Han Yu, Lung‐Yi Lu, Chun‐Hsien Chen, Yi‐Ting Chen, Wei‐Hsiang Liao, Shang‐Hsiu Hu, Hsin‐Lung Chen, Siriporn Jungsuttiwong, Ho‐Hsiu Chou   +14 more
wiley   +1 more source