Results 221 to 230 of about 107,106 (262)
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2014
Notch signaling is a master controller of the neural stem cell and neural development maintaining a significant role in the normal brain function. Notch genes are involved in embryogenesis, nervous system, and cardiovascular and endocrine function.
Eleftheria, Polychronidou +4 more
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Notch signaling is a master controller of the neural stem cell and neural development maintaining a significant role in the normal brain function. Notch genes are involved in embryogenesis, nervous system, and cardiovascular and endocrine function.
Eleftheria, Polychronidou +4 more
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Notch signalling in hematopoiesis
Seminars in Cell & Developmental Biology, 2003The Notch pathway is a widely utilized, evolutionarily conserved regulatory system that plays a central role in the fate decisions of multipotent precursor cells. Notch often acts by inhibiting differentiation along a particular pathway while permitting or promoting self-renewal or differentiation along alternative pathways.
K, Ohishi +4 more
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Current Molecular Medicine, 2006
The evolutionarily conserved developmental pathway driven by Notch receptors and ligands has acquired multiple post-natal homeostatic functions in vertebrates. Potential roles in human physiology and pathology are being studied by an increasingly large number of investigators.
Lucio, Miele +2 more
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The evolutionarily conserved developmental pathway driven by Notch receptors and ligands has acquired multiple post-natal homeostatic functions in vertebrates. Potential roles in human physiology and pathology are being studied by an increasingly large number of investigators.
Lucio, Miele +2 more
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Introduction to Notch Signaling
2014Notch signaling is probably the most widely used intercellular communication pathway. The Notch mutant in the fruit fly Drosophila melanogaster was isolated about 100 years ago at the dawn of genetics. Since then, research on Notch and its related genes in flies, worms, mice, and human has led to the establishment of an evolutionarily conserved ...
Shinya, Yamamoto +2 more
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Deciphering Notch signaling notch by notch
Cell Signaling, 2023Lidia Borkiewicz, Adolfo Rivero-Müller
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Notch Signaling in Osteoblasts
Science Signaling, 2008Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation ...
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Notch Signaling and Liver Cancer
2020Interactions between liver cells are closely regulated by Notch signaling. Notch signaling has been reported clinically related to bile duct hypogenesis in Alagille syndrome, which is caused by mutations in the Jagged1 gene. Notch activation and hepatocarcinogenesis are closely associated since cancer signaling is affected by the development of liver ...
Kazunori, Kawaguchi, Shuichi, Kaneko
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2018
Discovered nearly a century ago, today, Notch is known to mediate several biological processes through the canonical pathway that involves ligands, RBPJ, proteases, and coactivators. However, recent studies in vertebrates and invertebrates reveal that Notch can also exert its effect independent of RBPJ, in a noncanonical fashion.
Jyothi Vijayaraghavan +1 more
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Discovered nearly a century ago, today, Notch is known to mediate several biological processes through the canonical pathway that involves ligands, RBPJ, proteases, and coactivators. However, recent studies in vertebrates and invertebrates reveal that Notch can also exert its effect independent of RBPJ, in a noncanonical fashion.
Jyothi Vijayaraghavan +1 more
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Notch Signaling in Solid Tumors
2010In recent years a substantial body of evidence derived from not only preclinical but also clinical studies has accumulated in support of Notch signaling playing important oncogenic roles in several types of cancer. The finding that activating Notch mutations are frequently found in patients suffering from acute lymphoblastic leukemia is one of the best
Ute, Koch, Freddy, Radtke
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Science Signaling, 2010
Low-density lipoprotein receptor–related protein-1 promotes endocytosis that influences non–cell autonomous Notch signaling.
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Low-density lipoprotein receptor–related protein-1 promotes endocytosis that influences non–cell autonomous Notch signaling.
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