Results 231 to 240 of about 107,106 (262)
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Biodiversity and Noncanonical Notch Signaling
2010Early genetics in flies revealed that Notch is a complex pleiotropic locus. We now know that Notch is a receptor that plays prominent roles during development and functions locally in many tissues to instruct cell fate decisions. Drosophila has been an excellent model to identify genetically the elements that contribute to the canonical Notch signaling
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Notch signaling in lymphocyte development
Seminars in Immunology, 2002Cytokine and antigen receptor signals play well-characterized roles in promoting the survival and maturation of T and B lymphocyte progenitors through sequential developmental stages. Emerging studies suggest equally important roles for more ancient signaling pathways that evolved prior to the adaptive immune system in jawed vertebrates. In particular,
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Notch Signaling and Breast Cancer
2012It has been more than two decades since Notch has been identified as an oncogene in mouse mammary tumor virus-infected mice. Since this discovery, activated Notch signaling and up-regulation of tumor-promoting Notch target genes have been observed in human breast cancer.
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Targeting Notch in oncology: the path forward
Nature Reviews Drug Discovery, 2020Samarpan Majumder +2 more
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Therapeutic modulation of Notch signalling — are we there yet?
Nature Reviews Drug Discovery, 2014Emma R Andersson, Urban Lendahl
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Notch signalling: a simple pathway becomes complex
Nature Reviews Molecular Cell Biology, 2006Sarah Bray
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Kick it up a notch: Notch signaling and kidney fibrosis
Kidney International Supplements, 2014Katalin Susztak
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