Results 21 to 30 of about 107,106 (262)

NOTCH Signaling in Osteosarcoma

Current Issues in Molecular Biology, 2023
The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high. Therefore, it is crucial to explore new therapeutic targets and strategies that are more effective.
Zhenhao Zhang, Wei Wu, Zengwu Shao
openaire   +3 more sources

Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration

Scientific Reports, 2022
To control sprouting angiogenesis, endothelial Notch signaling suppresses tip cell formation, migration, and proliferation while promoting barrier formation. Each of these responses may be regulated by distinct Notch-regulated effectors.
Bhairavi Swaminathan, Seock-Won Youn, L. A. Naiche, Jing Du, Stephanie R. Villa, Jordan B. Metz, Huijuan Feng, Chaolin Zhang, Raphael Kopan, Peter A. Sims, Jan K. Kitajewski   +10 more
doaj   +1 more source

The Notch signaling pathway controls CD8+ T cell differentiation independently of the classical effector HES1.

PLoS ONE, 2019
During CD8+ T cell response, Notch signaling controls short-lived-effector-cell (SLEC) generation, but the exact mechanisms by which it does so remains unclear.
Dave Maurice De Sousa, Frédéric Duval, Jean-François Daudelin, Salix Boulet, Nathalie Labrecque   +4 more
doaj   +1 more source

Significant Roles of Notch O-Glycosylation in Cancer

Molecules, 2022
Notch signaling, which was initially identified in Drosophila wing morphogenesis, plays pivotal roles in cell development and differentiation. Optimal Notch pathway activity is essential for normal development and dysregulation of Notch signaling leads ...
Weiwei Wang, Tetsuya Okajima, Hideyuki Takeuchi   +2 more
doaj   +1 more source

The histone deacetylase HDAC1 positively regulates Notch signaling during Drosophila wing development

Biology Open, 2018
The Notch signaling pathway is highly conserved across different animal species and plays crucial roles in development and physiology. Regulation of Notch signaling occurs at multiple levels in different tissues and cell types.
Zehua Wang, Jialan Lyu, Fang Wang, Chen Miao, Zi Nan, Jiayu Zhang, Yongmei Xi, Qi Zhou, Xiaohang Yang, Wanzhong Ge   +9 more
doaj   +1 more source

The Role of Notch Signaling in Macrophages during Inflammation and Infection: Implication in Rheumatoid Arthritis?

Cells, 2020
Notch signaling coordinates numerous cellular processes and has been implicated in many pathological conditions, including rheumatoid arthritis (RA).
Esra’a Keewan, Saleh A. Naser
doaj   +1 more source

Blockage of Notch Signaling Inhibits the Migration and Proliferation of Retinal Pigment Epithelial Cells

The Scientific World Journal, 2013
The Notch signaling is an evolutionarily conserved cell-cell communication pathway that plays critical roles in the proliferation, survival, apoptosis, and fate determination of mammalian cells.
Weiwei Liu, Guorong Jin, Chongde Long, Xin Zhou, Yan Tang, Shan Huang, Xielan Kuang, Lizi Wu, Qingjiong Zhang, Huangxuan Shen   +9 more
doaj   +1 more source

NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies

Frontiers in Immunology, 2018
The NOTCH (1–4) family of receptors are highly conserved and are critical in regulating many developmental processes and in the maintenance of tissue homeostasis.
Michelle A. Kelliher, Justine E. Roderick   +1 more
doaj   +1 more source

The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation

Biomolecules, 2021
Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limited ...
Judith Hounjet, Marc Vooijs
doaj   +1 more source

Notch Ligand Binding Assay Using Flow Cytometry

Bio-Protocol, 2017
Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013).
Shweta Varshney, Pamela Stanley
doaj   +1 more source