Results 31 to 40 of about 190,719 (307)

NOTCH Signaling in Osteosarcoma

Current Issues in Molecular Biology, 2023
The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high. Therefore, it is crucial to explore new therapeutic targets and strategies that are more effective.
Zhenhao Zhang, Wei Wu, Zengwu Shao
openaire   +3 more sources

Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration

Scientific Reports, 2022
To control sprouting angiogenesis, endothelial Notch signaling suppresses tip cell formation, migration, and proliferation while promoting barrier formation. Each of these responses may be regulated by distinct Notch-regulated effectors.
Bhairavi Swaminathan, Seock-Won Youn, L. A. Naiche, Jing Du, Stephanie R. Villa, Jordan B. Metz, Huijuan Feng, Chaolin Zhang, Raphael Kopan, Peter A. Sims, Jan K. Kitajewski   +10 more
doaj   +1 more source

The Notch signaling pathway controls CD8+ T cell differentiation independently of the classical effector HES1.

PLoS ONE, 2019
During CD8+ T cell response, Notch signaling controls short-lived-effector-cell (SLEC) generation, but the exact mechanisms by which it does so remains unclear.
Dave Maurice De Sousa, Frédéric Duval, Jean-François Daudelin, Salix Boulet, Nathalie Labrecque   +4 more
doaj   +1 more source

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states [PDF]

, 2014
The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major challenge is to determine how these components control the specificity and directionality of Notch ...
Elowitz, Michael B., Jafar-Nejad, Hamed, LeBon, Lauren, Lee, Tom V., Sprinzak, David   +4 more
core   +1 more source

Significant Roles of Notch O-Glycosylation in Cancer

Molecules, 2022
Notch signaling, which was initially identified in Drosophila wing morphogenesis, plays pivotal roles in cell development and differentiation. Optimal Notch pathway activity is essential for normal development and dysregulation of Notch signaling leads ...
Weiwei Wang, Tetsuya Okajima, Hideyuki Takeuchi   +2 more
doaj   +1 more source

The Role of Notch Signaling in Macrophages during Inflammation and Infection: Implication in Rheumatoid Arthritis?

Cells, 2020
Notch signaling coordinates numerous cellular processes and has been implicated in many pathological conditions, including rheumatoid arthritis (RA).
Esra’a Keewan, Saleh A. Naser
doaj   +1 more source

Genome-wide screen for genes involved in Caenorhabditis elegans developmentally timed sleep [PDF]

, 2017
In Caenorhabditis elegans, Notch signaling regulates developmentally timed sleep during the transition from L4 larval stage to adulthood (L4/A) . To identify core sleep pathways and to find genes acting downstream of Notch signaling, we undertook the ...
Hart, Anne C, Hayden, Dustin J, Huang, Huiyan, Skuja, Lukas L, Zhu, Chen-Tseh   +4 more
core   +3 more sources

Blockage of Notch Signaling Inhibits the Migration and Proliferation of Retinal Pigment Epithelial Cells

The Scientific World Journal, 2013
The Notch signaling is an evolutionarily conserved cell-cell communication pathway that plays critical roles in the proliferation, survival, apoptosis, and fate determination of mammalian cells.
Weiwei Liu, Guorong Jin, Chongde Long, Xin Zhou, Yan Tang, Shan Huang, Xielan Kuang, Lizi Wu, Qingjiong Zhang, Huangxuan Shen   +9 more
doaj   +1 more source

Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. [PDF]

, 2016
BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Chuang, Yung-Jen, Huang, Yi-Ching, Jao, Li-En, Jiang, Jie-Peng, Lai, Zih-Yin, Lin, Min-Hsuan, Liu, Lawrence Yu-Min   +6 more
core   +2 more sources

The histone deacetylase HDAC1 positively regulates Notch signaling during Drosophila wing development

Biology Open, 2018
The Notch signaling pathway is highly conserved across different animal species and plays crucial roles in development and physiology. Regulation of Notch signaling occurs at multiple levels in different tissues and cell types.
Zehua Wang, Jialan Lyu, Fang Wang, Chen Miao, Zi Nan, Jiayu Zhang, Yongmei Xi, Qi Zhou, Xiaohang Yang, Wanzhong Ge   +9 more
doaj   +1 more source