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Origin of the Chordate Notochord [PDF]
Diversity, 2021 The phylum of Chordata is defined based on the discovery of a coelom-like dorsal notochord in ascidian and amphioxus embryos. Chordata can be classified into three subphylums, Cephalochordata, Urochordata, and Vertebrata, united by the presence of a ...
Zihao Sui, Zhihan Zhao, Bo Dong
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Eph regulates dorsoventral asymmetry of the notochord plate and convergent extension-mediated notochord formation. [PDF]
PLoS ONE, 2010 The notochord is a signaling center required for the patterning of the vertebrate embryonic midline, however, the molecular and cellular mechanisms involved in the formation of this essential embryonic tissue remain unclear.
Izumi Oda-Ishii +2 more
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Diverse logics and grammar encode notochord enhancers
Cell Reports, 2023 Summary: The notochord is a defining feature of all chordates. The transcription factors Zic and ETS regulate enhancer activity within the notochord. We conduct high-throughput screens of genomic elements within developing Ciona embryos to understand how
Benjamin P. Song +6 more
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Spine Patterning Is Guided by Segmentation of the Notochord Sheath
Cell Reports, 2018 Summary: The spine is a segmented axial structure made of alternating vertebral bodies (centra) and intervertebral discs (IVDs) assembled around the notochord.
Kaelyn Sumigray +2 more
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Notochord Cells in Intervertebral Disc Development and Degeneration
Journal of Developmental Biology, 2016 The intervertebral disc is a complex structure responsible for flexibility, multi-axial motion, and load transmission throughout the spine. Importantly, degeneration of the intervertebral disc is thought to be an initiating factor for back pain. Due to a
Cheryle Seguin, Matthew McCann
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Prenatal muscle forces are necessary for vertebral segmentation and disc structure, but not for notochord involution in mice [PDF]
European Cells & Materials, 2021 Embryonic muscle forces are necessary for normal vertebral development and spinal curvature, but their involvement in intervertebral disc (IVD) development remains unclear.
A Levillain +7 more
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Frontiers in Cell and Developmental Biology, 2023 Keratan sulfate (KS) is a glycosaminoglycan that is enriched in vertebrate cornea, cartilage, and brain. During embryonic development, highly sulfated KS (HSKS) is first detected in the developing notochord and then in otic vesicles; therefore, HSKS has ...
Yuuri Yasuoka, Yuuri Yasuoka
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Protocadherin-1 is expressed in the notochord of mouse embryo but is dispensable for its formation
Biochemistry and Biophysics Reports, 2021 Notochord is an embryonic midline structure that serves as mechanical support for axis elongation and the signaling center for the surrounding tissues.
Kanako Fukunaga +4 more
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eLife, 2022 Gene regulatory networks coordinate the formation of organs and structures that compose the evolving body plans of different organisms. We are using a simple chordate model, the Ciona embryo, to investigate the essential gene regulatory network that ...
Yushi Wu +8 more
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Gene expression in notochord and nuclei pulposi: a study of gene families across the chordate phylum
BMC Ecology and Evolution, 2023 The transition from notochord to vertebral column is a crucial milestone in chordate evolution and in prenatal development of all vertebrates.
Rahul Raghavan +14 more
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