RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis [PDF]
, 2012 Background: Repulsive guidance molecules (RGM) are high-affinity ligands for the Netrin receptor Neogenin, and they are crucial for nervous system development including neural tube closure; neuronal and neural crest cell differentiation and axon guidance.
Coutinho, L. +9 more
core +1 more source
Transcriptome sequencing of Atlantic salmon (Salmo salar L.) notochord prior to development of the vertebrae provides clues to regulation of positional fate, chordoblast lineage and mineralisation [PDF]
, 2014 Background: In teleosts such as Atlantic salmon (Salmo salar L.), segmentation and subsequent mineralisation of the notochord during embryonic stages are essential for normal vertebrae formation.
Shou Wang +15 more
core +1 more source
Notochord development in Atlantic salmon (Salmo salar L.): exploring molecular pathways and putative mechanism of segmentation [PDF]
, 2014 Background: A key feature of the vertebrate body plan is the repeated compartments made up of individual vertebra, blood vessels, peripheral nerves and muscle.
Wang, Shou
core +1 more source
Transient infection of the zebrafish notochord with E. coli induces chronic inflammation
Disease Models & Mechanisms, 2014 Zebrafish embryos and larvae are now well-established models in which to study infectious diseases. Infections with non-pathogenic Gram-negative Escherichia coli induce a strong and reproducible inflammatory response. Here, we study the cellular response
Mai Nguyen-Chi +5 more
doaj +1 more source
BMC Evolutionary Biology, 2011 Background The notochord is a defining feature of the chordate clade, and invertebrate chordates, such as tunicates, are uniquely suited for studies of this structure. Here we used a well-characterized set of 50 notochord genes known to be targets of the
Jiang Di +4 more
doaj +1 more source
Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish
Disease Models & Mechanisms, 2019 The aberrant activation of developmental processes triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from transformed notochord remnants.
Gianluca D'Agati +8 more
doaj +1 more source
Notochord and spinal malformations [PDF]
Acta Orthopaedica Scandinavica, 1986 Fourteen spinal malformations were found in 328 spontaneously aborted human embryos and fetuses. Of these, 13 were investigated histologically and histomorphometrically and compared with 47 age- and stagematched normal specimens to document any possible relationship between spinal and notochordal malformations.
S, Goto, H K, Uhthoff
openaire +2 more sources
Notochord vacuoles absorb compressive bone growth during zebrafish spine formation
eLife, 2020 The vertebral column or spine assembles around the notochord rod which contains a core made of large vacuolated cells. Each vacuolated cell possesses a single fluid-filled vacuole, and loss or fragmentation of these vacuoles in zebrafish leads to spine ...
Jennifer Bagwell +9 more
doaj +1 more source
Quantitative Dissection of the Proximal Ciona brachyury Enhancer
Frontiers in Cell and Developmental Biology, 2022 A major goal in biology is to understand the rules by which cis-regulatory sequences control spatially and temporally precise expression patterns. Here we present a systematic dissection of the proximal enhancer for the notochord-specific transcription ...
Kotaro Shimai, Michael Veeman
doaj +1 more source
Polarity Establishment and Maintenance in Ascidian Notochord
Frontiers in Cell and Developmental Biology, 2020 Cell and tissue polarity due to the extracellular signaling and intracellular gene cascades, in turn, signals the directed cell behaviors and asymmetric tissue architectures that play a crucial role in organogenesis and embryogenesis.
Hongzhe Peng +4 more
doaj +1 more source