Results 11 to 20 of about 4,292 (162)
The development of the human notochord. [PDF]
PLoS ONE, 2018 The notochord is a major regulator of embryonic patterning in vertebrates and abnormal notochordal development is associated with a variety of birth defects in man.
Karel de Bree +2 more
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Conserved enhancers control notochord expression of vertebrate Brachyury [PDF]
Nature Communications, 2023 The cell type-specific expression of key transcription factors is central to development and disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression is ...
Cassie L. Kemmler +19 more
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Tunicates push the limits of animal evo-devo [PDF]
BMC Biology, 2011 The phylum to which humans belong, Chordata, takes its name from one of the major shared derived features of the group, the notochord. All chordates have a notochord, at least during embryogenesis, and there is little doubt about notochord homology at ...
Ferrier David EK
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Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae [PDF]
Bio-Protocol, 2018 Zebrafish have become an increasingly important model organism in the field of wound healing and regenerative medicine, due to their high regenerative capacity coupled with high-resolution imaging in living animals.
Zhiqiang Zeng +8 more
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Reaction wavefront theory of notochord segment patterning [PDF]
Frontiers in Physics, 2022 The vertebrate axis is segmented into repetitive structures, the vertebrae. In fish, these segmented structures are thought to form from the paraxial mesoderm and the adjacent notochord.
Sol M. Fernández Arancibia +5 more
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Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord. [PDF]
PLoS Genetics, 2015 A main challenge of modern biology is to understand how specific constellations of genes are activated to differentiate cells and give rise to distinct tissues. This study focuses on elucidating how gene expression is initiated in the notochord, an axial
Diana S José-Edwards +6 more
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Persistent Notochord in a Fetus with COL2A1 Mutation [PDF]
Case Reports in Obstetrics and Gynecology, 2015 Multiple anomalies including micromelia, poor mineralization of the vertebrae, and a persistent notochord were identified on second trimester ultrasound in a fetus with a COL2A1 mutation.
Elisabeth Codsi +4 more
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Disease Models & Mechanisms, 2021 Notochordal cells play a pivotal role in vertebral column patterning, contributing to the formation of the inner architecture of intervertebral discs (IVDs).
Paco López-Cuevas +4 more
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Animals, 2023 Osteoarthritis is a degenerative articular disease affecting mainly aging animals and people. The extracellular matrix protein Efemp1 was previously shown to have higher turn-over and increased secretion in the blood serum, urine, and subchondral bone of
Ratish Raman +10 more
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Cells, 2023 The dual-specificity tyrosine phosphorylation-regulated kinase (DYRK1) phosphorylates diverse substrates involved in various cellular processes. Here, we found that blocking the kinase activity of DYRK1 inhibited notochord development and lumenogenesis ...
Zhuqing Wang +4 more
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