Results 41 to 50 of about 4,292 (162)

Development of the Mouse Notochord [PDF]

, 2009
During development of the vertebrate embryo, a highly conserved tissue called the organizer forms during gastrulation, and is required for establishment of the basic body plan.
Tamplin, Owen James
core   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

A novel zebrafish mutant with wavy-notochord: An effective biological index for monitoring the copper pollution of water from natural resources

, 2010
We identified a novel zebrafish mutant that has wavy-notochord phenotypes, such as severely twisted notochord and posterior malformations, but has normal melanocytes.
Chen, Yau-hung; Lin, Ji-sheng, Ji‐Sheng Lin, Yau‐Hung Chen, Chen, Yau-hung   +3 more
core   +1 more source

Notochord isolation using laser capture microdissection [PDF]

, 2017
Background: Chordoma are malignant tumors of the axial skeleton, which arise from remnants of the notochord. The Notochord (chorda dorsalis) is an essential embryonic structure involved in the development of the nervous system and axial skeleton ...
Yakkioui, Y., Van Overbeeke, J. J., Raven, G., Santegoeds, R. G. C., Jahanshahi, A., Herrler, A., Temel, Y.   +6 more
core   +2 more sources

Foxa1 and Foxa2 are required for formation of the intervertebral discs.

PLoS ONE, 2013
The intervertebral disc (IVD) is composed of 3 main structures, the collagenous annulus fibrosus (AF), which surrounds the gel-like nucleus pulposus (NP), and hyaline cartilage endplates, which are attached to the vertebral bodies.
Jennifer A Maier, YinTing Lo, Brian D Harfe   +2 more
doaj   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Generation of Mouse Notochord Cell Lines for the Study of Notochord Function during Intervertebral Disk Development

Global Spine Journal, 2012
Introduction Degeneration of intervertebral disks (IVDs) is the most common cause of back pain. Herniation of disk material into vertebral column and the reduction of disk thickness are the two prominent clinical features.
T. Y. Au, D. Chan, K. Cheah
doaj   +1 more source

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

Disease Models & Mechanisms, 2012
SUMMARY Back pain related to intervertebral disc degeneration is the most common musculoskeletal problem, with a lifetime prevalence of 82%. The lack of effective treatment for this widespread problem is directly related to our limited understanding of ...
Matthew R. McCann, Owen J. Tamplin, Janet Rossant, Cheryle A. Séguin   +3 more
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source