Results 81 to 90 of about 57,135 (271)

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder. [PDF]

open access: yesJ Intern Med
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Ledri M, Kokaia M.
europepmc   +2 more sources

Pancreatic cancer cachexia: a review of mechanisms and therapeutics. [PDF]

open access: yes, 2014
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge.
Andrew Eugene Hendifar   +8 more
core   +2 more sources

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska   +4 more
wiley   +1 more source

NPY's mixed messages [PDF]

open access: yesThe Journal of Experimental Medicine, 2005
A stress hormone sends mixed signals to immune cells, according to a study on page 1527. Wheway and colleagues show that neuropeptide Y (NPY) activates antigen-presenting cells (APCs) but shuts off T cells. If correctly sequenced, these activities would both turn on and then limit certain immune responses.NPY is an abundant neuropeptide that is ...
openaire   +1 more source

The Strongly Asynchronous Massive Access Channel

open access: yes, 2018
This paper considers a Strongly Asynchronous and Slotted Massive Access Channel (SAS-MAC) where $K_n:=e^{n\nu}$ different users transmit a randomly selected message among $M_n:=e^{nR}$ ones within a strong asynchronous window of length $A_n:=e^{n\alpha}$
Devroye, Natasha   +2 more
core   +2 more sources

A DNA methylation assay (MPap) using self‐collected tampon versus cytology collection swab for endometrial cancer detection

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the practicability of self‐collected tampons with the MPap assay for endometrial cancer (EC) detection, by comparing with the results of cervical swabs. Methods A total of 85 women at Tri‐Service General Hospital (TSGH) were included to directly compare the performance of physician‐collected swabs and self‐collected ...
Kuo‐Min Su   +5 more
wiley   +1 more source

Neuropeptide Y enhances olfactory mucosa responses to odorant in hungry rats. [PDF]

open access: yesPLoS ONE, 2012
Neuropeptide Y (NPY) plays an important role in regulating appetite and hunger in vertebrates. In the hypothalamus, NPY stimulates food intake under the control of the nutritional status.
Julia Negroni   +6 more
doaj   +1 more source

Galanin receptor 2 modifies neuropeptide Y Y1 receptor internalization and β-Arrestin recruitment [PDF]

open access: yes, 2015
We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers.
Borroto-Escuela, Dasiel   +8 more
core  

The role of traditional medicine practice in primary health care within Aboriginal Australia: a review of the literature [PDF]

open access: yes, 2013
This literature review attempts to identify and examine, both qualitatively and quantitatively, traditional medicine practices within Aboriginal Australia today.AbstractThe practice of traditional Aboriginal medicine within Australia is at risk of being ...
Stefanie J Oliver
core   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

open access: yesPhytotherapy Research, EarlyView.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli   +4 more
wiley   +1 more source

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