Results 121 to 127 of about 2,154 (127)

1802-P: Nr1d1/Nr1d2 in POMC Neurons Regulates Circadian Eating Behaviors and Energy Expenditure

Diabetes, 2019
Proopiomelanocortin (POMC) neurons in the arcuate nucleus of ventral hypothalamus and the nucleus tractus solitarius are involved in many biological functions. Nuclear receptor Nr1d1 and Nr1d2 are the key component of the molecular circadian clock machinery and are widely expressed in the brain.
WENJUN ZHOU, TINGTING YANG, XIN LI, ZHENG SUN   +3 more
openaire   +1 more source

Abstract 16484: The Transcriptional Repressor NR1D2 is Associated With Congenital Heart Disease and Plays an Evolutionarily Conserved Role in Cardiac Development

Circulation, 2015
Title: The Transcriptional Repressor NR1D2 is Associated with Congenital Heart Disease and Plays an Evolutionarily Conserved Role in Cardiac Development. Introduction: Congenital heart disease (CHD) is a leading cause of morbidity and mortality in young children and the underlying ...
James R Priest, Georg Vogler, Sylvia Nurnberg, Michael Portman, Bruce D Gelb, Euan A Ashley, Rolf Bodmer, Thomas Quertermous   +7 more
openaire   +1 more source

Abstract 1357: Inhibition of breast cancer cell growth by a synthetic ligand targeting the nuclear receptor, REV-ERB (NR1D1 and NR1D2)

Cancer Research, 2011
Abstract Disruption of the circadian rhythm leads to increased risk for development of breast cancer in humans. The molecular mechanism underlying the link between circadian rhythm disruption and the increased risk of breast cancer in humans is not clear.
Yongjun Wang, Theodore Kamenecka, Douglas Kojetin, Thomas P. Burris   +3 more
openaire   +1 more source

Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

Abstract Hormone therapy resistance and the ensuing aggressive progression of tumors present a significant clinical challenge. However, the mechanisms underlying the induction of tumor malignancy by hormone inhibition remain poorly understood.
Xianping Wang, Yifan Guo, Peng Lin, Min Yu, Sha Song, Wenyan Xu, Du Kong, Yin Wang, Yanxiao Zhang, Fei Lu, Qi Xie, Xianjue Ma   +11 more
openaire   +1 more source

Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection

Autophagy, 2021
Chenglong Rao, Jianping Xie, Jingmin Yan   +2 more
exaly  

Novel CLOCK and NR1D2 variants in 64 sighted Japanese individuals with non-24-hour sleep–wake rhythm disorder

Sleep, 2023
Yuichi Inoue, Hiroshi Kadotani, Aritoshi Iida   +2 more
exaly  

Human nuclear hormone receptor activity contributes to malaria parasite liver stage development

Cell Chemical Biology, 2023
exaly