Results 21 to 30 of about 69,085 (277)

The combination of mutations in BRAF and NRAS genes within a one tumor in patients with cutaneous melanoma

Бюллетень сибирской медицины, 2019
The paper provides a clinical description and analysis of two melanoma cases with mutations in the BRAF and NRAS gene within one tumor. Until recently, it was believed that mutations in the BRAF and NRAS genes are exclusive and do not occur within the ...
M. B. Aksenenko, A. S. Averchuk, T. G. Ruksha   +2 more
doaj   +1 more source

MicroRNA-708 emerges as a potential candidate to target undruggable NRAS.

PLoS ONE, 2023
RAS, the most frequently mutated oncogene that drives tumorigenesis by promoting cell proliferation, survival, and motility, has been perceived as undruggable for the past three decades.
Jia Meng Pang, Po-Chen Chien, Ming-Chien Kao, Pei-Yun Chiu, Pin-Xu Chen, Yu-Ling Hsu, Chengyang Liu, Xiaowei Liang, Kai-Ti Lin   +8 more
doaj   +1 more source

PIK3CA mutations in advanced cancers: characteristics and outcomes. [PDF]

, 2012
PIK3CA mutations are frequently diagnosed in diverse cancers and may predict response to PI3K/AKT/mTOR inhibitors. It remains unclear whether they are associated with other characteristics.
Falchook, Gerald S, Fu, Siqing, Garrido-Laguna, Ignacio, Hong, David S, Janku, Filip, Kurzrock, Razelle, Lee, Jack J, Luthra, Rajyalakshmi, Moulder, Stacy L, Naing, Aung, Piha-Paul, Sarina A, Stepanek, Vanda M, Tsimberidou, Apostolia M, Wheler, Jennifer J   +13 more
core   +4 more sources

KRAS/NRAS Mutations Associated with Distant Metastasis and BRAF/PIK3CA Mutations Associated with Poor Tumor Differentiation in Colorectal Cancer

International Journal of General Medicine, 2023
Juanzi Zeng,1,2 Wenwei Fan,3 Jiaquan Li,1,2 Guowu Wu,1,2 Heming Wu2 1Department of Medical Oncology, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Center for Precision Medicine, Meizhou People’s ...
Zeng J, Fan W, Li J, Wu G, Wu H
doaj  

Correlation between KRAS, NRAS and BRAF mutations and tumor localizations in patients with primary and metastatic colorectal cancer

Archives of Medical Science, 2021
Introduction Detection of abnormalities in the KRAS, NRAS and BRAF genes is extremely important for proper qualification of colorectal cancer (CRC) patients for therapy with anti-EGFR (epidermal growth factor receptor) monoclonal antibodies.
Aleksandra Bożyk, Paweł Krawczyk, Katarzyna Reszka, Kinga Krukowska, Agnieszka Kolak, Sławomir Mańdziuk, Kamila Wojas-Krawczyk, Rodryg Ramlau, Janusz Milanowski   +8 more
doaj   +1 more source

The frequency of NRAS mutation in stool samples of Iranian colorectal cancers compared to Finnish patients

Journal of Research in Medical Sciences
Background: Stools from colorectal cancer patients are noninvasive samples that could be used to compare the frequency of hotspot mutations between two different ethnic cohorts.
Farideh Saberi, Omar Youssef, Arto Kokkola, Mahsa Khodadoostan, Pauli Puolakkainen, Rasoul Salehi, Sakari Knuutila   +6 more
doaj   +1 more source

The first maps of κd - the dust mass absorption coefficient - in nearby galaxies, with DustPedia [PDF]

, 2019
The dust mass absorption coefficient, κd is the conversion function used to infer physical dust masses from observations of dust emission. However, it is notoriously poorly constrained, and it is highly uncertain how it varies, either between or within ...
Baes, Maarten, Bianchi, S, Casasola, V, Cassarà, LP, Clark, CJR, Davies, JI, De Looze, Ilse, De Vis, P, Dobbels, Wouter, Evans, R, Galametz, M, Galliano, F, Jones, AP, Lianou, S, Madden, SC, Mosenkov, AV, Verstocken, Sam, Viaene, Sébastien, Xilouris, EM, Ysard, N   +19 more
core   +1 more source

miR-145-5p suppresses cell proliferation by targeting IGF1R and NRAS genes in multiple myeloma cells

Türk Biyokimya Dergisi, 2023
Multiple myeloma (MM) is a common hematological cancer. Hence, it is important to conduct further studies investigating the molecular mechanisms in detail that contributes to myeloma genesis.
Kaya Murat, Suer Ilknur, Ozgur Emre, Capik Ozel, Karatas Omer Faruk, Ozturk Sukru, Gezer Ugur, Palanduz Sukru, Cefle Kivanc   +8 more
doaj   +1 more source

Molecular-genetic mechanisms of the signal cascade RAS-RAF-MEK-ERK associated with the development of the tumor process and the purpose of targeted drugs for colorectal cancer

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021
Colorectal cancer occupies one of the leading positions in the world in the structure of cancer incidence. The vital processes of cancer cells largely depend on the production of growth factors and their receptors. One of these is epidermal growth factor
A. N. Toropovsky, O. N. Pavlova, D. A. Viktorov, A. G. Nikitin   +3 more
doaj   +1 more source

Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS [PDF]

Royal Society Open Science, 2018
The expression profile of miRNAs and their function in condyloma acuminatum (CA) remains unknown. In this study, we aimed to detect the effects of miR-143 and miR-145, the most downregulated in CA samples using high-throughput sequencing, on cell ...
Xiaoyan Liu, Yu Zhang, Su Wang, Guoying Liu, Liming Ruan   +4 more
doaj   +1 more source