Results 11 to 20 of about 9,676 (179)

Inhibitors of NS5A for Treatment of HCV Infection [PDF]

ACS Medicinal Chemistry Letters, 2013
Inhibitors of NS5A for Treatment of HCV Infection Jean-Francois Brazeau and Gerard Rosse* Structure Guided Chemistry, Dart Neuroscience LLC, 7473 Lusk Boulevard, San Diego, California 92121, United States Adjunct Associate Professor, Department of Pharmacology and Physiology, College of Medicine, Drexel University, New College Building, 245 North 15th ...
Jean-Francois, Brazeau, Gerard, Rosse
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Synergistic Activity of Combined NS5A Inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 2016
ABSTRACT Daclatasvir (DCV) is a first-in-class hepatitis C virus (HCV) nonstructural 5A replication complex inhibitor (NS5A RCI) that is clinically effective in interferon-free combinations with direct-acting antivirals (DAAs) targeting alternate HCV proteins.
Donald R, O'Boyle, Peter T, Nower, Min, Gao, Robert, Fridell, Chunfu, Wang, Piyasena, Hewawasam, Omar, Lopez, Yong, Tu, Nicholas A, Meanwell, Makonen, Belema, Susan B, Roberts, Mark, Cockett, Jin-Hua, Sun   +12 more
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Autophagy Induced by the N-Terminus of the Classic Swine Fever Virus Nonstructural Protein 5A Protein Promotes Viral Replication

Frontiers in Microbiology, 2021
Although classic swine fever virus (CSFV) infection has been reported to induce autophagy, the specific induced mechanism remains unrevealed. Nonstructural protein 5A (NS5A) of CSFV is a multiphosphorylated protein with multiple functions to regulate ...
Chengcheng Zhang, Xiuling Wang, Jiahao Sun, Mengjiao Guo, Xiaorong Zhang, Yantao Wu   +5 more
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Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase [PDF]

Journal of Virology, 1997
NS5A derived from a hepatitis C virus (HCV) genotype 1b isolate has previously been shown to undergo phosphorylation on serine residues (T. Kaneko, Y. Tanji, S. Satoh, M. Hijikata, S. Asabe, K. Kimura, and K. Shimotohno, Biochem. Biophys. Res. Commun. 205:320-326, 1994).
K E, Reed, J, Xu, C M, Rice
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HCV NS5A dimer interface residues regulate HCV replication by controlling its self-interaction, hyperphosphorylation, subcellular localization and interaction with cyclophilin A.

PLoS Pathogens, 2018
The HCV NS5A protein plays multiple roles during viral replication, including viral genome replication and virus particle assembly. The crystal structures of the NS5A N-terminal domain indicated the potential existence of the NS5A dimers formed via at ...
Saravanabalaji Shanmugam, Alyssa K Nichols, Dhanaranjani Saravanabalaji, Christoph Welsch, MinKyung Yi   +4 more
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The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization

Journal of General Virology, 2011
Hepatitis C virus (HCV) non-structural protein 5A (NS5A) is a multi-functional protein that is expressed in basally phosphorylated (p56) and in hyperphosphorylated (p58) forms. NS5A phosphorylation has been implicated in regulating multiple aspects of HCV replication. We recently reported the identification of a class of compounds that potently inhibit
Dike, Qiu, Julie A, Lemm, Donald R, O'Boyle, Jin-Hua, Sun, Peter T, Nower, Van, Nguyen, Lawrence G, Hamann, Lawrence B, Snyder, Daniel H, Deon, Edward, Ruediger, Nicholas A, Meanwell, Makonen, Belema, Min, Gao, Robert A, Fridell   +13 more
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Genotyping atypical porcine pestivirus using NS5a

Infection, Genetics and Evolution, 2021
Atypical porcine pestivirus (APPV) is an emerging virus discovered in 2014 and it can cause congenital tremors in pigs. Molecular epidemiology serves as an essential tool in monitoring and controlling the disease. Virus epidemiology mainly relies on genome sequencing and phylogenetic characterization.
Fangfeng, Yuan, Leyi, Wang
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Mutations in E2-PePHD, NS5A-PKRBD, NS5A-ISDR, and NS5A-V3 of Hepatitis C Virus Genotype 1 and Their Relationships to Pegylated Interferon-Ribavirin Treatment Responses [PDF]

Journal of Virology, 2008
ABSTRACTMutations in several subgenomic regions of hepatitis C virus (HCV) have been implicated in influencing the response to interferon (IFN) therapy. Sequences within HCV NS5A (PKR binding domain [PKRBD], IFN sensitivity-determining region [ISDR], and variable region 3 [V3]) were analyzed for the pretreatment serum samples of 60 HCV genotype 1 ...
P, Muñoz de Rueda, J, Casado, R, Patón, D, Quintero, A, Palacios, A, Gila, R, Quiles, J, León, A, Ruiz-Extremera, J, Salmerón   +9 more
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Investigating Genotype 1a HCV Drug Resistance in NS5A Region via Bayesian Inference

Tsinghua Science and Technology, 2015
Hepatitis C virus (HCV) treatment is on the cutting edge of medicine. Due to the high rate of mutations and low fidelity of HCV replication, resistant strains quickly become dominant in a viral population under the selection pressure of a drug.
Yao Fu, Gang Chen, Lizhi Fu, Jing Zhang
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Direct binding of ledipasvir to HCV NS5A: mechanism of resistance to an HCV antiviral agent.

PLoS ONE, 2015
Ledipasvir, a direct acting antiviral agent (DAA) targeting the Hepatitis C Virus NS5A protein, exhibits picomolar activity in replicon cells. While its mechanism of action is unclear, mutations that confer resistance to ledipasvir in HCV replicon cells ...
Hyock Joo Kwon, Weimei Xing, Katie Chan, Anita Niedziela-Majka, Katherine M Brendza, Thorsten Kirschberg, Darryl Kato, John O Link, Guofeng Cheng, Xiaohong Liu, Roman Sakowicz   +10 more
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