Results 31 to 40 of about 17,579 (227)

Fast Hepatitis C Virus RNA Elimination and NS5A Redistribution by NS5A Inhibitors Studied by a Multiplex Assay Approach [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT While earlier therapeutic strategies for the treatment of hepatitis C virus (HCV) infection relied exclusively on interferon (IFN) and ribavirin (RBV), four direct-acting antiviral agents (DAAs) have now been approved, aiming for an interferon-free strategy with a short treatment duration and fewer side effects.
Dandan, Liu, Juan, Ji, Tanya P, Ndongwe, Eleftherios, Michailidis, Charles M, Rice, Robert, Ralston, Stefan G, Sarafianos   +6 more
openaire   +2 more sources

Retreatment of patients with chronic hepatitis C, subtype 3a, and cirrhosis, who previously failed a regimen containing NS5A inhibitors with sofosbuvir/velpatasvir plus ribavirin for 24 weeks

Journal of Clinical Virology Plus, 2023
Background & Aims The use of direct acting antiviral agents (DAAs) in patients with chronic HCV genotype (GT) 3a infection results in sustained virologic response (SVR) rates of 93–98%, but 5–8% of patients experience virologic failure. Methods.
Sergii V. Fedorchenko, Tatiana Martynovych, Zhanna Klimenko, Iryna Solianyk   +3 more
doaj   +1 more source

Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization. [PDF]

, 2009
Hepatitis C virus (HCV) entry occurs via a pH- and clathrin-dependent endocytic pathway and requires a number of cellular factors, including CD81, the tight-junction proteins claudin 1 (CLDN1) and occludin, and scavenger receptor class B member I (SR-BI).
Balfe, Peter, Grove, Joe, Hu, Ke, McKeating, Jane A, Mee, Christopher J, Schwarz, Anne K   +5 more
core   +2 more sources

HCV NS5A and IRF9 compete for CypA binding [PDF]

Journal of Hepatology, 2013
Cyclophilin A (CypA) is vital for HCV replication. Cyp inhibitors successfully decrease viral loads in HCV-infected patients. However, their mechanisms of action remain unknown. Since interferon (IFN) can also suppress HCV replication, we asked whether a link between CypA and the IFN response exists.We used cellular and recombinant pulldown approaches ...
Michael, Bobardt, Sam, Hopkins, James, Baugh, Udayan, Chatterji, Felicia, Hernandez, John, Hiscott, Ann, Sluder, Kai, Lin, Philippe A, Gallay   +8 more
openaire   +2 more sources

Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A.

PLoS ONE, 2010
BackgroundHepatitis C Virus (HCV) infection is a leading indication for liver transplantation. HCV infection reoccurs almost universally post transplant, decreasing both graft longevity and patient survival.
Fiona Fernandes, Israr-ul H Ansari, Rob Striker   +2 more
doaj   +1 more source

Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.

PLoS Pathogens, 2012
Hepatitis C virus (HCV) is an important cause of chronic liver disease. Several highly diverse HCV genotypes exist with potential key functional differences.
Troels K H Scheel, Jannick Prentoe, Thomas H R Carlsen, Lotte S Mikkelsen, Judith M Gottwein, Jens Bukh   +5 more
doaj   +1 more source

Complete replication of hepatitis C virus in cell culture. [PDF]

, 2005
Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen.
Burton, Dennis R, Evans, Matthew J, Hynes, Richard O, Lindenbach, Brett D, Liu, Christopher C, Maruyama, Toshiaki, McKeating, Jane A, Rice, Charles M, Syder, Andrew J, Tellinghuisen, Timothy L, Wölk, Benno   +10 more
core   +1 more source

NMR and circular dichroism data for domain 2 of the HCV NS5A protein phosphorylated by the Casein Kinase II

Data in Brief, 2018
The Hepatitis C Virus (HCV)11 HCV: Hepatitis C Virus; HSQC: heteronuclear single-quantum coherence; NS5A: nonstructural protein 5A; NS5A-D2: domain 2 of the nonstructural protein 5A; CKII: Casein kinase II, NS5A-D2_CKII: NS5A-D2 phosphorylated by CKII ...
Luiza M. Bessa, Robert Schneider, Xavier Hanoulle   +2 more
doaj   +1 more source

Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy [PDF]

, 2014
Hepatitis C virus (HCV) infection represents an important public health problem worldwide. Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors.
Carpio Pedroza, Juan Carlos, Cruz Rivera, Mayra, Escobar Gutierrez, Alejandro, Fonseca Coronado, Salvador, Martinez Guarneros, Armando, Preciado, María Victoria, Rahal, Paula, Ruiz Tovar, Karina, Valva, Pamela, Vazquez Chacon, Carlos, Yamasaki, Lilian   +10 more
core   +1 more source

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus [PDF]

, 2014
In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been ...
Hague, Charlotte V., Liefhebber, Jolanda M.P., McLauchlan, John, Wakelam, Michael J.O., Zhang, Qifeng   +4 more
core   +1 more source