Results 21 to 30 of about 12,817 (217)
Frontiers in Microbiology, 2021 Although classic swine fever virus (CSFV) infection has been reported to induce autophagy, the specific induced mechanism remains unrevealed. Nonstructural protein 5A (NS5A) of CSFV is a multiphosphorylated protein with multiple functions to regulate ...
Chengcheng Zhang +5 more
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PLoS Pathogens, 2018 The HCV NS5A protein plays multiple roles during viral replication, including viral genome replication and virus particle assembly. The crystal structures of the NS5A N-terminal domain indicated the potential existence of the NS5A dimers formed via at ...
Saravanabalaji Shanmugam +4 more
doaj +1 more source
Prevalence of baseline polymorphisms for potential resistance to NS5A inhibitors in drug-naive individuals infected with hepatitis C genotypes 1–4 [PDF]
, 2014 Background: The non-structural 5A (NS5A) protein of HCV is a multifunctional phosphoprotein involved in regulation of viral replication and virion assembly.
Webster, D.P. +5 more
core +1 more source
, 2021 Mit 71 Millionen chronisch erkrankten Patienten im Jahr 2015 stellt die chronische Hepatitis C-Virusinfektion eine wichtige Ursache für Zirrhose, Leberdekompensation und Leberkrebs dar.
Grimm, Christian
core +1 more source
Investigating Genotype 1a HCV Drug Resistance in NS5A Region via Bayesian Inference
Tsinghua Science and Technology, 2015 Hepatitis C virus (HCV) treatment is on the cutting edge of medicine. Due to the high rate of mutations and low fidelity of HCV replication, resistant strains quickly become dominant in a viral population under the selection pressure of a drug.
Yao Fu, Gang Chen, Lizhi Fu, Jing Zhang
doaj +1 more source
Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase [PDF]
Journal of Virology, 1997 NS5A derived from a hepatitis C virus (HCV) genotype 1b isolate has previously been shown to undergo phosphorylation on serine residues (T. Kaneko, Y. Tanji, S. Satoh, M. Hijikata, S. Asabe, K. Kimura, and K. Shimotohno, Biochem. Biophys. Res. Commun. 205:320-326, 1994).
K E, Reed, J, Xu, C M, Rice
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Virulence, 2020 Classical swine fever virus (CSFV), a positive-sense RNA virus, hijacks cell host proteins for its own replication. Rab18, a small Rab GTPase, regulates intracellular membrane-trafficking events between various compartments in cells and is involved in ...
Liang Zhang +6 more
doaj +1 more source
PLoS ONE, 2013 Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the
Seung-Ae Yim +3 more
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Annals of Hepatology, 2022 Introduction and Objectives: Hepatitis C virus (HCV) NS5A and Core proteins play a key role in carcinogenesis development. Epithelial-mesenchymal transition (EMT) induced by HCV has been related to Snail and TGFβ1 upregulation and E-cadherin ...
TG Heredia-Torres +3 more
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Genotyping atypical porcine pestivirus using NS5a
Infection, Genetics and Evolution, 2021 Atypical porcine pestivirus (APPV) is an emerging virus discovered in 2014 and it can cause congenital tremors in pigs. Molecular epidemiology serves as an essential tool in monitoring and controlling the disease. Virus epidemiology mainly relies on genome sequencing and phylogenetic characterization.
Fangfeng, Yuan, Leyi, Wang
openaire +2 more sources