Results 21 to 30 of about 17,579 (227)

Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation.

PLoS ONE, 2013
Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the
Seung-Ae Yim, Yun-Sook Lim, Jong-Wook Kim, Soon B Hwang   +3 more
doaj   +1 more source

Multiple effects of silymarin on the hepatitis C virus lifecycle [PDF]

, 2010
Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo.
Bourne, Nigel, Brimacombe, Claire L, Cao, Feng, Graf, Tyler N, Grove, Joe, Kane, Olivia J, Lohmann, Volker, Martinez, Laura E, McKeating, Jane A, Nahmias, Yaakov, Negash, Amina, Oberlies, Nicholas H, Owen, David M, Polyak, Stephen J, Pécheur, Eve-Isabelle, Tavis, John E, Wagoner, Jessica   +16 more
core   +1 more source

Mutations in E2-PePHD, NS5A-PKRBD, NS5A-ISDR, and NS5A-V3 of Hepatitis C Virus Genotype 1 and Their Relationships to Pegylated Interferon-Ribavirin Treatment Responses [PDF]

Journal of Virology, 2008
ABSTRACTMutations in several subgenomic regions of hepatitis C virus (HCV) have been implicated in influencing the response to interferon (IFN) therapy. Sequences within HCV NS5A (PKR binding domain [PKRBD], IFN sensitivity-determining region [ISDR], and variable region 3 [V3]) were analyzed for the pretreatment serum samples of 60 HCV genotype 1 ...
P, Muñoz de Rueda, J, Casado, R, Patón, D, Quintero, A, Palacios, A, Gila, R, Quiles, J, León, A, Ruiz-Extremera, J, Salmerón   +9 more
openaire   +2 more sources

Efficient Hepatitis C Virus Genotype 1b Core-NS5A Recombinants Permit Efficacy Testing of Protease and NS5A Inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 2017
ABSTRACT Hepatitis C virus (HCV) strains belong to seven genotypes with numerous subtypes that respond differently to antiviral therapies. Genotype 1, and primarily subtype 1b, is the most prevalent genotype worldwide. The development of recombinant HCV infectious cell culture systems for different variants, permitted by the high
Pham, Long V., Ramirez Almeida, Santseharay, Carlsen, Thomas H R, Li, Yi-Ping, Gottwein, Judith M., Bukh, Jens   +5 more
openaire   +3 more sources

Hepatitis C virus NS5A and core proteins regulate epithelial-mesenchymal transition biomarkers in hepatoma cells

Annals of Hepatology, 2022
Introduction and Objectives: Hepatitis C virus (HCV) NS5A and Core proteins play a key role in carcinogenesis development. Epithelial-mesenchymal transition (EMT) induced by HCV has been related to Snail and TGFβ1 upregulation and E-cadherin ...
TG Heredia-Torres, SA Lozano-Sepúlveda, AR Rincón-Sánchez, AMG Rivas-Estilla   +3 more
doaj   +1 more source

Ferritin heavy chain Is the host factor responsible for HCV-Induced inhibition of apoB-100 production and is required for efficient viral infection [PDF]

, 2012
Hepatic fat export occurs by apolipoprotein B-100-containing lipoprotein production, whereas impaired production leads to liver steatosis. Hepatitis C virus (HCV) infection is associated to dysregulation of apoB-100 secretion and steatosis; however, the ...
AMICONE, Laura, Claudia Montaldo, Cristina Di Giacomo, Giuseppe Ippolito, Laura Santangelo, Leopoldo Paolo Pucillo, MANCONE, Carmine, Tonino Alonzi, TRIPODI, Marco, Viviana Costa   +9 more
core   +3 more sources

Inhibitors of NS5A for Treatment of HCV Infection [PDF]

ACS Medicinal Chemistry Letters, 2013
Inhibitors of NS5A for Treatment of HCV Infection Jean-Francois Brazeau and Gerard Rosse* Structure Guided Chemistry, Dart Neuroscience LLC, 7473 Lusk Boulevard, San Diego, California 92121, United States Adjunct Associate Professor, Department of Pharmacology and Physiology, College of Medicine, Drexel University, New College Building, 245 North 15th ...
Jean-Francois, Brazeau, Gerard, Rosse
openaire   +2 more sources

A new method of producing NS5A antigen of hepatitis C virus

Вопросы вирусологии, 2017
A task of creating a universal platform for engineering affordable recombinant producers of viral proteins conserving immunogenicity has not been solved yet.
T. V. Kuznetsova, M. S. Smirnova, O. A. Leonovich, I. V. Gordeichuk, I. K. Biriukova, M. V. Zylkova, Ya. Ya. Tyn’O, A. V. Belyakova, A. B. Shevelev   +8 more
doaj   +1 more source

A comprehensive functional map of the hepatitis C virus genome provides a resource for probing viral proteins. [PDF]

, 2014
UnlabelledPairing high-throughput sequencing technologies with high-throughput mutagenesis enables genome-wide investigations of pathogenic organisms. Knowledge of the specific functions of protein domains encoded by the genome of the hepatitis C virus ...
Arumugaswami, Vaithilingaraja, Chen, Shu-Hwa, Chen, Zugen, Chu, Virginia, Lin, Chung-Yen, Lo, Hung-Hao, Olson, C Anders, Qi, Hangfei, Remenyi, Roland, Stokelman, Tamar, Su, Sheng-Yao, Sun, Ren, Truong, Shawna, Wu, Nicholas C, Wu, Ting-Ting   +14 more
core   +2 more sources

Charakterisierung des Lipidbindungsverhaltens und der Proteinfaltung von HCV NS5A unter Einfluss des NS5A-Inhibitors Daclatasvir [PDF]

, 2021
Mit 71 Millionen chronisch erkrankten Patienten im Jahr 2015 stellt die chronische Hepatitis C-Virusinfektion eine wichtige Ursache für Zirrhose, Leberdekompensation und Leberkrebs dar. Eine grundlegende Eigenschaft des Hepatitis C-Virus (HCV) ist die Biogenese modifizierter intrazellulärer Membranen.
openaire   +2 more sources