Results 21 to 30 of about 9,676 (179)

Rab18 binds to classical swine fever virus NS5A and mediates viral replication and assembly in swine umbilical vein endothelial cells

Virulence, 2020
Classical swine fever virus (CSFV), a positive-sense RNA virus, hijacks cell host proteins for its own replication. Rab18, a small Rab GTPase, regulates intracellular membrane-trafficking events between various compartments in cells and is involved in ...
Liang Zhang, Di Zhao, Mingxing Jin, Mengzhao Song, Shanchuan Liu, Kangkang Guo, Yanming Zhang   +6 more
doaj   +1 more source

Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation.

PLoS ONE, 2013
Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the
Seung-Ae Yim, Yun-Sook Lim, Jong-Wook Kim, Soon B Hwang   +3 more
doaj   +1 more source

Identification of Hepatitis C Virus NS5A Inhibitors [PDF]

Journal of Virology, 2010
ABSTRACT Using a cell-based replicon screen, we identified a class of compounds with a thiazolidinone core structure as inhibitors of hepatitis C virus (HCV) replication. The concentration of one such compound, BMS-824, that resulted in a 50% inhibition of HCV replicon replication was ∼5 nM, with a therapeutic index of >10,000. The
Julie A, Lemm, Donald, O'Boyle, Mengping, Liu, Peter T, Nower, Richard, Colonno, Milind S, Deshpande, Lawrence B, Snyder, Scott W, Martin, Denis R, St Laurent, Michael H, Serrano-Wu, Jeffrey L, Romine, Nicholas A, Meanwell, Min, Gao   +12 more
openaire   +2 more sources

Hepatitis C virus NS5A and core proteins regulate epithelial-mesenchymal transition biomarkers in hepatoma cells

Annals of Hepatology, 2022
Introduction and Objectives: Hepatitis C virus (HCV) NS5A and Core proteins play a key role in carcinogenesis development. Epithelial-mesenchymal transition (EMT) induced by HCV has been related to Snail and TGFβ1 upregulation and E-cadherin ...
TG Heredia-Torres, SA Lozano-Sepúlveda, AR Rincón-Sánchez, AMG Rivas-Estilla   +3 more
doaj   +1 more source

HCV NS5A and IRF9 compete for CypA binding [PDF]

Journal of Hepatology, 2013
Cyclophilin A (CypA) is vital for HCV replication. Cyp inhibitors successfully decrease viral loads in HCV-infected patients. However, their mechanisms of action remain unknown. Since interferon (IFN) can also suppress HCV replication, we asked whether a link between CypA and the IFN response exists.We used cellular and recombinant pulldown approaches ...
Michael, Bobardt, Sam, Hopkins, James, Baugh, Udayan, Chatterji, Felicia, Hernandez, John, Hiscott, Ann, Sluder, Kai, Lin, Philippe A, Gallay   +8 more
openaire   +2 more sources

A new method of producing NS5A antigen of hepatitis C virus

Вопросы вирусологии, 2017
A task of creating a universal platform for engineering affordable recombinant producers of viral proteins conserving immunogenicity has not been solved yet.
T. V. Kuznetsova, M. S. Smirnova, O. A. Leonovich, I. V. Gordeichuk, I. K. Biriukova, M. V. Zylkova, Ya. Ya. Tyn’O, A. V. Belyakova, A. B. Shevelev   +8 more
doaj   +1 more source

Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A.

PLoS ONE, 2010
BackgroundHepatitis C Virus (HCV) infection is a leading indication for liver transplantation. HCV infection reoccurs almost universally post transplant, decreasing both graft longevity and patient survival.
Fiona Fernandes, Israr-ul H Ansari, Rob Striker   +2 more
doaj   +1 more source

Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.

PLoS Pathogens, 2012
Hepatitis C virus (HCV) is an important cause of chronic liver disease. Several highly diverse HCV genotypes exist with potential key functional differences.
Troels K H Scheel, Jannick Prentoe, Thomas H R Carlsen, Lotte S Mikkelsen, Judith M Gottwein, Jens Bukh   +5 more
doaj   +1 more source

Retreatment of patients with chronic hepatitis C, subtype 3a, and cirrhosis, who previously failed a regimen containing NS5A inhibitors with sofosbuvir/velpatasvir plus ribavirin for 24 weeks

Journal of Clinical Virology Plus, 2023
Background & Aims The use of direct acting antiviral agents (DAAs) in patients with chronic HCV genotype (GT) 3a infection results in sustained virologic response (SVR) rates of 93–98%, but 5–8% of patients experience virologic failure. Methods.
Sergii V. Fedorchenko, Tatiana Martynovych, Zhanna Klimenko, Iryna Solianyk   +3 more
doaj   +1 more source

NMR and circular dichroism data for domain 2 of the HCV NS5A protein phosphorylated by the Casein Kinase II

Data in Brief, 2018
The Hepatitis C Virus (HCV)11 HCV: Hepatitis C Virus; HSQC: heteronuclear single-quantum coherence; NS5A: nonstructural protein 5A; NS5A-D2: domain 2 of the nonstructural protein 5A; CKII: Casein kinase II, NS5A-D2_CKII: NS5A-D2 phosphorylated by CKII ...
Luiza M. Bessa, Robert Schneider, Xavier Hanoulle   +2 more
doaj   +1 more source