Results 51 to 60 of about 12,817 (217)

Phosphorylation of Serine 235 of the Hepatitis C Virus Non-Structural Protein NS5A by Multiple Kinases.

PLoS ONE, 2016
Phosphorylation at serine 235 (S235) of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) plays a critical role in the viral life cycle. For medical and virological interests, we exploited the HEK293T kidney cells to test 3 candidate protein ...
Kuan-Ying Lee, Yi-Hung Chen, Shih-Chin Hsu, Ming-Jiun Yu   +3 more
doaj   +1 more source

Prevalence of Naturally-Occurring NS5A and NS5B Resistance-Associated Substitutions in Iranian Patients With Chronic Hepatitis C Infection

Frontiers in Microbiology, 2021
BackgroundHepatitis C virus (HCV), non-structural 5A (NS5A), and non-structural 5B (NS5B) resistance-associated substitutions (RASs) are the main causes of failure to direct-acting antiviral agents (DAAs).
Pooneh Rahimi, Heidar Sharafi, Golnaz Bahramali, FaridehSadat SajadianFard, Nafiseh Sadat Asadi, Seyed Moayed Alavian, Vahid Iranpur Mobarakeh, Seyedeh Zahra Moravej   +7 more
doaj   +1 more source

Persistent Hepatitis C Viremia Following Sofosbuvir/Velpatasvir During Bendamustine‐Rituximab Therapy for Follicular Lymphoma

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT This is a case of a 67‐year‐old female with follicular lymphoma who developed hepatitis C viremia during chemotherapy and failed treatment with a 12‐week course of sofosbuvir/velpatasvir. This highlights the possibility that chemotherapy may have contributed to failure to achieve sustained virologic response despite otherwise appropriate ...
Chisom J. Orakwue, Rade N. Pejic
wiley   +1 more source

Identification of VAPB domain binding with NS5A.

, 2012
(a). Domain organization of the 447-residue HCV NS5A protein consisting of three domains. (b). Prediction of disorder tendency of the full-length NS5A with IUPred server (http://iupred.enzim.hu/). (c). Far UV CD spectra of NS5A(33–447) (blue); NS5A-D1(33–
Haina Qin (143174), Garvita Gupta (158903), Jianxing Song (143189)   +2 more
core   +1 more source

Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein.

PLoS Pathogens, 2013
The nonstructural protein NS5A has emerged as a new drug target in antiviral therapies for Hepatitis C Virus (HCV) infection. NS5A is critically involved in viral RNA replication that takes place at newly formed membranes within the endoplasmic reticulum
Dorothee A Vogt, Grégory Camus, Eva Herker, Brian R Webster, Chia-Lin Tsou, Warner C Greene, Tien-Sze Benedict Yen, Melanie Ott   +7 more
doaj   +1 more source

The effects of NS5A dimer interface mutations on NS5A and CypA interaction.

, 2018
(A) Interaction between CypA and H77 NS5A or JFH1 NS5A detected by performing a checkmate mammalian two-hybrid assay. Results are from three independent experiments.
Alyssa K. Nichols (5545664), MinKyung Yi (362029), Saravanabalaji Shanmugam (5545667), Dhanaranjani Saravanabalaji (5545670), Christoph Welsch (22852)   +4 more
core   +1 more source

Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation

, 2020
The radical SAM enzyme, viperin, exerts a wide range of antiviral effects through both the synthesis of the antiviral nucleotide 3′-deoxy-3′,4′-didehydro-CTP (ddhCTP) and through its interactions with various cellular and viral proteins.
Soumi Ghosh (773732), E. Neil G. Marsh, E. Neil G. Marsh (8378205), Timothy J. Grunkemeyer, Robert T. Kennedy (368322), Arti B. Dumbrepatil, Arti B. Dumbrepatil (8378199), Kelcie Zegalia (8378202), Ayesha M. Patel, Ayesha M. Patel (8378193), Robert T. Kennedy, Kelcie Zegalia, Timothy J. Grunkemeyer (8378196), Soumi Ghosh   +13 more
core   +1 more source

Enrichment of NS5A in ApoE-positive structures and co-trafficking of ApoE^mT2 with NS5A and E2 independent of HCV assembly.

, 2023
(A) Experimental approach. Fluorescently tagged ApoEmT2, HCV proteins supporting assembly (C to NS2 with eYFP-tagged E2), and a subgenomic replicon (dotted lines indicate 5’ and 3’ NTRs) are shown from top to bottom; the experimental approach is depicted
Karl Rohr (41937), Uta Haselmann (12969434), Janis Meyer (16705902), Vibor Laketa (12969446), Ralf Bartenschlager (32666), Minh-Tu Pham (16705896), Ji-Young Lee (113856), Roman Thielemann (16705899), Charlotta Funaya (84151), Christian Ritter (3447533)   +9 more
core   +1 more source

Phytochemical analysis of Berberis lyceum methanolic extract and its antiviral activity through the restoration of MAPK signaling pathway modulated by HCV NS5A

Asian Pacific Journal of Tropical Biomedicine, 2021
Objective: To evaluate the antiviral activity and phytochemicals of selected plant extracts and their effect on the mitogen-activated protein kinase (MAPK) signaling pathway modulated by hepatitis C virus (HCV) nonstructural protein 5A (NS5A). Methods: A
Koloko Brice Landry, Shafiq Azam, Sidra Rehman, Somayya Tariq, Bushra Iqbal, Mateen Abbas, Dieudonné Massoma Lembè, Bushra Ijaz   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source