Results 61 to 70 of about 12,817 (217)
Cells, 2019 Mitophagy is a selective form of autophagy, targeting damaged mitochondria for lysosomal degradation. Although HCV infection has been shown to induce mitophagy, the precise underlying mechanism and the effector protein responsible remain unclear. Herein,
Alagie Jassey +5 more
doaj +1 more source
The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo +4 more
wiley +1 more source
, 2013 A: Experimental setup of transcomplementation experiments: Huh7-Lunet cells bearing either a persistent HCV replicon (I) or constitutively expressing HCV NS3 to NS5A (II) or NS5A (III), respectively, are transfected with luciferase reporter replicons ...
Volker Lohmann (115772) +8 more
core +1 more source
Юг России: экология, развитиеTo research the molecular genetic characteristics of the HCV population circulating among HIV‐infected residents of the Krasnoyarsk Territory, including analysis of resistance‐associated mutations to NS5A inhibitors.
V. E. Ekushov +7 more
doaj +1 more source
GPS2 is required for the association of NS5A with VAP-A and hepatitis C virus replication.
PLoS ONE, 2013 Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a component of the replication complex associated with various cellular proteins. It has been reported that G protein pathway suppressor 2 (GPS2) is a potential NS5A-binding factor, as identified
Guodong Xu, Xiu Xin, Congyi Zheng
doaj +1 more source
Hepatitis C virus genetic diversity by geographic region within genotype 1-6 subtypes among patients treated with glecaprevir and pibrentasvir. [PDF]
PLoS ONE, 2018 Hepatitis C virus (HCV) is genetically diverse and includes 7 genotypes and 67 confirmed subtypes, and the global distribution of each HCV genotype (GT) varies by geographic region. In this report, we utilized a large dataset of NS3/4A and NS5A sequences
Gretja Schnell +11 more
doaj +1 more source
Bemnifosbuvir: An HCV NS5B Inhibitor With Multiple Modes of Action
Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 552-562, August 2026.Bemnifosbuvir (BEM) is a potent, pan‐genotypic inhibitor targeting the hepatitis C virus (HCV) NS5B polymerase. Its antiviral activity was evaluated in an ascending dose phase I clinical trial involving 30 patients treated once a day for 7 days. After treatment initiation, plasma HCV RNA declined in a biphasic manner with a mean reduction of 2.3 log10 ...
Carolin Zitzmann +4 more
wiley +1 more source
Identification of NS5A domain binding with VAPB.
, 2012 (a). Superimposition of 1H-15N NMR HSQC spectra of VAPB(1–125) in the absence of (black) and in the presence of unlabeled long NS5A-D3(300–447) at molar ratios of 1∶1.5 (green) and 1∶2.5 (red) (VAPB/NS5A). (b).
Haina Qin (143174) +2 more
core +1 more source
Hepatology Research, Volume 56, Issue 8, Page 1202-1212, August 2026.ABSTRACT Aim The aim of this all‐case post‐marketing study was to evaluate the real‐world safety and effectiveness in all children and adolescents with chronic hepatitis C with or without compensated cirrhosis treated with glecaprevir/pibrentasvir (G/P) in Japan. Methods This prospective, observational post‐marketing surveillance study was conducted at
Tatsuki Mizuochi +6 more
wiley +1 more source
NS5A dimer interface mutations impaired NS5A and core interaction.
, 2018 (A) Confocal imaging analysis of cells at day 3 post-electroporation of HJ3-5/NS5AYFP RNA with or without indicated individual mutations following core immunostaining (Alexa Fluor 405) and LipidTOX deep red neutral lipid stain.
Alyssa K. Nichols (5545664) +4 more
core +1 more source