Virtual screening, optimization design, and synthesis analysis of novel benzofuran derivatives as pan-genotypic HCV NS5B polymerase inhibitors using molecular modeling [PDF]
BMC ChemistryHepatitis C virus (HCV) infection is a global health concern, with HCV exhibiting high variability across eight major genotypes and multiple subtypes. A series of benzofuran inhibitors have been proven to exhibit effective antiviral effects on HCV NS5B ...
Di Han +13 more
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Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA – effects on NS5B catalysis and allosteric inhibition [PDF]
Virology Journal, 2017 Background Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV) therapy and clearance for a majority of patients, but are not available or effective for all patients.
Sara M. Ø. Solbak +3 more
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Hepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteins. [PDF]
PLoS Pathogens, 2015 Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood.
Teymur Kazakov +5 more
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In Silico Characterization of Two Human Pegivirus Proteins Highlights Similarities with Hepatitis C Virus and Possible Therapeutic Repurposing [PDF]
VirusesHuman Pegivirus (HPgV) is an understudied flavivirus that is highly prevalent and often persists in the blood and tissues of humans. HPgV-infected brain tissue from individuals with Parkinson’s disease has shown significant transcriptomic and immune ...
Kaleigh M. Copenhaver +3 more
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Structural insights into polymerase-catalyzed FAD capping of hepatitis C virus RNA [PDF]
Nature CommunicationsThe RNA polymerase NS5B of HCV is capable of catalyzing the addition of flavin adenine dinucleotide (FAD) to its RNA as a 5′ cap structure, aiding the virus in evading host immune responses.
De-Ping Wang +6 more
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VAPC, an human endogenous inhibitor for hepatitis C virus (HCV) infection, is intrinsically unstructured but forms a "fuzzy complex" with HCV NS5B. [PDF]
PLoS ONE, 2012 Nearly 200 million people are infected by hepatitis C virus (HCV) worldwide. For replicating the HCV genome, the membrane-associated machinery needs to be formed by both HCV non-structural proteins (including NS5B) and human host factors such as VAPB ...
Shaveta Goyal +6 more
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Hepatitis C virus NS3 helicase contributes to (−) strand RNA synthesis [PDF]
Nature CommunicationsMany positive strand RNA viruses encode helicases, but their distinct functions in viral replication cycles is poorly understood. Here, we identify a mutation in the helicase domain of HCV non-structural protein 3 (NS3h), D1467G, which specifically ...
Philipp Ralfs +9 more
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Computational and Structural Biotechnology Journal, 2021 GS-9669 is a non-nucleos(t)ide inhibitor (NNI) binding to the thumb site II of the Hepatitis C virus (HCV) NS5B polymerase and has advanced into phase II trials.
Di Han +5 more
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Virology Journal, 2022 Background Hepatitis C virus (HCV) infection increased the risk of hepatocellular carcinoma. Identification of host factors required for HCV infection will help to unveil the HCV pathogenesis.
Muhammad Ikram Anwar +8 more
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The cobas® HCV GT is a new tool that accurately identifies Hepatitis C virus genotypes for clinical practice. [PDF]
PLoS ONE, 2017 OBJECTIVE:We aimed to evaluate the correct assignment of HCV genotype/subtypes 1a and 1b by cobas® HCV genotyping (GT) assay (Roche Molecular Diagnostics) compared with nonstructural protein 5B (NS5B) sequencing.
J A Fernández-Caballero +4 more
doaj +1 more source