Results 11 to 20 of about 15,799 (221)

Proline to Threonine Mutation at Position 162 of NS5B of Classical Swine Fever Virus Vaccine C Strain Promoted Genome Replication and Infectious Virus Production by Facilitating Initiation of RNA Synthesis

Viruses, 2021
The 3′untranslated region (3′UTR) and NS5B of classical swine fever virus (CSFV) play vital roles in viral genome replication. In this study, two chimeric viruses, vC/SM3′UTR and vC/b3′UTR, with 3′UTR substitution of CSFV Shimen strain or bovine viral ...
Huining Pang, Ling Li, Hongru Liu, Zishu Pan   +3 more
doaj   +1 more source

A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A. [PDF]

PLoS ONE, 2011
RNA synthesis by the genotype 1b hepatitis C virus (HCV) polymerase (NS5B) transiently expressed in Human embryonic kidney 293T cells or liver hepatocytes was found to robustly stimulate RIG-I-dependent luciferase production from the interferon β ...
C T Ranjith-Kumar, Yahong Wen, Nielson Baxter, Kanchan Bhardwaj, C Cheng Kao   +4 more
doaj   +1 more source

Akt Phosphorylation of Hepatitis C Virus NS5B Regulates Polymerase Activity and Hepatitis C Virus Infection

Frontiers in Microbiology, 2021
Hepatitis C virus (HCV) is a single-stranded RNA virus of positive polarity [ssRNA(+)] that replicates its genome through the activity of one of its proteins, called NS5B.
Rosario Sabariegos, Rosario Sabariegos, Rosario Sabariegos, Laura Albentosa-González, Blanca Palmero, Pilar Clemente-Casares, Pilar Clemente-Casares, Pilar Clemente-Casares, Eugenio Ramírez, Carlos García-Crespo, Carlos García-Crespo, Isabel Gallego, Isabel Gallego, Ana Isabel de Ávila, Ana Isabel de Ávila, Celia Perales, Celia Perales, Celia Perales, Esteban Domingo, Esteban Domingo, Esteban Domingo, Antonio Mas, Antonio Mas, Antonio Mas   +23 more
doaj   +1 more source

First report on molecular docking analysis and drug resistance substitutions to approved HCV NS5A and NS5B inhibitors amongst Iranian patients

BMC Gastroenterology, 2021
Background NS5A and NS5B proteins of hepatitis C virus (HCV) are the main targets of compounds that directly inhibit HCV infections. However, the emergence of resistance-associated substitutions (RASs) may cause substantial reductions in susceptibility ...
Zahra Hasanshahi, Ava Hashempour, Farzane Ghasabi, Javad Moayedi, Zahra Musavi, Behzad Dehghani, Heidar Sharafi, Hassan Joulaei   +7 more
doaj   +1 more source

Distribution of naturally -occurring NS5B resistance-associated substitutions in Egyptian patients with chronic Hepatitis C.

PLoS ONE, 2021
BackgroundNS5B polymerase inhibitors represent the cornerstone of the present treatment of Hepatitis C virus infection (HCV). Naturally occurring substitution mutations to NS5B inhibitors have been recorded.
Hala Rady Ahmed, Nancy G F M Waly, Rehab Mahmoud Abd El-Baky, Ramadan Yahia, Helal F Hetta, Amr M Elsayed, Reham Ali Ibrahem   +6 more
doaj   +1 more source

Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication [PDF]

, 2012
All positive strand RNA viruses are known to replicate their genomes in close association with intracellular membranes. In case of the hepatitis C virus (HCV), a member of the family Flaviviridae, infected cells contain accumulations of vesicles forming ...
Antony, Claude, Bartenschlager, Ralf, Chiramel, Abhilash, Chlanda, Petr, Habermann, Anja, Haselman, Uta, Hoppe, Simone, Kallis, Stephanie, Krijnse-Locker, Jacomine, Lee, Ji-Young, Merz, Andreas, Romero-Brey, Inés, Santarella-Mellwig, Rachel, Walther, Paul   +13 more
core   +7 more sources

Computational analysis of resistance mutations in the hepatitis C virus

Revista Vínculos, 2018
Hepatitis C virus (HCV) continues to be a public health problem worldwide. The development of drugs that target virus proteins such as NS5B, aims to provide more effective treatment in the future.
Karina Salvatierra, Hector Florez
doaj   +1 more source

Multiple effects of silymarin on the hepatitis C virus lifecycle [PDF]

, 2010
Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo.
Bourne, Nigel, Brimacombe, Claire L, Cao, Feng, Graf, Tyler N, Grove, Joe, Kane, Olivia J, Lohmann, Volker, Martinez, Laura E, McKeating, Jane A, Nahmias, Yaakov, Negash, Amina, Oberlies, Nicholas H, Owen, David M, Polyak, Stephen J, Pécheur, Eve-Isabelle, Tavis, John E, Wagoner, Jessica   +16 more
core   +1 more source

Phylogeography, Risk Factors and Genetic History of Hepatitis C Virus in Gabon, Central Africa [PDF]

, 2012
BACKGROUND: The epidemiological and molecular characteristics of hepatitis C virus (HCV) infection in the general population have been poorly investigated in Africa.
Besson, Guillaume, Caron, Mélanie, Kazanji, Mirdad, Leroy, Eric, Makuwa, Maria, Ndong-Atome, Guy-Roger, Njouom, Richard, Nkoghé, Dieudonné, Pouillot, Régis   +8 more
core   +8 more sources

Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]

, 2012
Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair, Amjesh R, Sugunan V.S.   +2 more
core   +2 more sources