Results 111 to 120 of about 15,799 (221)

形成丙型肝炎病毒负链复制体的相关蛋白的分析

Zhongshan Daxue xuebao. Yixue kexue ban, 2002
【目的】确定丙型肝炎病毒(HCV)非结构蛋白NS5B 以及肝母细胞瘤株HepG2 胞浆提取物中的宿主蛋白与 HCV 负链RNA 3′末端的特异性结合作用。【方法】用蛋白-核酸紫外交联试验分别检测NS5B 以及HepG2 胞浆提取物中的宿 主蛋白与HCV 负链RNA 3′末端的结合作用, 用非同源RNA 和非同源蛋白作为竞争物分析这种结合的特异性。【结果】 NS5B 以及宿主细胞内一约45 ku 的蛋白质(简称P45)均可与HCV 负链RNA 3′末端特异性结合。【结论】NS5B 和P45 是 ...
黄开红, 邓庆丽, 王　巍, 邵　静, 黄志明   +4 more
doaj  

Spread of Hepatitis C Virus among European Injection Drug Users Infected with HIV: A Phylogenetic Analysis [PDF]

, 2017
To describe the spread of hepatitis C virus (HCV) among HCV/human immunodeficiency virus (HIV)-coinfected injection drug users (IDUs), the molecular epidemiology of HCV was studied among 108 IDUs from 7 European countries.
Boufassa, Faroudy, Brettle, Raymond P., Broers, Barbara, Cochrane, Alexandra, Coutinho, Roel A., Hernandez-Aguado, Ildefonso, Lamzira, Saida, McMenamin, Jim, Prins, Maria, Rezza, Giovanni, Robertson, J. Roy, Simmonds, Peter, van Asten, Liselotte, Verhaest, Inge, Zangerle, Robert   +14 more
core  

HCV NS5B polymerase [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Non-structural protein 5B (NS5B) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Clinical and virological properties of hepatitis C virus genotype 4 infection in patients treated with different direct-acting antiviral agents

Infection and Drug Resistance, 2018
Claudia Minosse,1,* Marina Selleri,1,* Emanuela Giombini,1 Barbara Bartolini,1 Maria Rosaria Capobianchi,1 Stefano Cerilli,2 Laura Loiacono,2 Chiara Taibi,2 Gianpiero D’Offizi,2 Fiona McPhee,3 AnnaRosa Garbuglia1 1Department of Pre-clinical ...
Minosse C, Selleri M, Giombini E, Bartolini B, Capobianchi MR, Cerilli S, Loiacono L, Taibi C, D'Offizi G, McPhee F, Garbuglia AR   +10 more
doaj  

HCV NS4B protein; HCV NS5B polymerase [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Novel indole derivatives as hepatitis C virus NS5B polymerase inhibitors: Pharmacophore modeling and 3D QSAR studies

Bangladesh Journal of Pharmacology, 2014
Hepatitis C Virus (HCV) encodes its own RNA dependent RNA polymerase (NS5b) in order to replicate its genome. An efficient pharmacophore was identified, by executing structural analysis of a set of 49 indole-based inhibitors of the HCV NS5B polymerase ...
G. Varun, M. Lokesh, M. Sandeep, Sajad Shahbazi, Deepak Reddy Gade   +4 more
doaj  

Hepatitis C Virus 5'UTR Sequences That Bind eIF3 and Ribosomal 40S Subunits Confer Stimulation of Minus-Strand RNA Synthesis. [PDF]

Int J Mol Sci
Malik AQ, Shalamova L, Khajouei M, Budnik J, Hell AL, Jost E, Gerresheim GK, Rossbach O, Niepmann M.   +8 more
europepmc   +1 more source

Substituted Benzofurans as Inhibitors of HCV NS5B Protein [PDF]

ACS Medicinal Chemistry Letters, 2013
openaire   +2 more sources

A dual role for ER-Golgi cargo receptor LMAN1 in supporting CSFV replication and restraining RLR signaling. [PDF]

J Virol
Han K, Chang Z, Li N, Xiao D, Song M, Wang T, Guo K, Zhang L, Deng W.   +8 more
europepmc   +1 more source