Results 81 to 90 of about 15,799 (221)

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Andrew Tuplin, Bartenschlager, Blight, Blight, Brown, Bukh, Cheng, David J. Evans, Davis, Diviney, Friebe, Friebe, Friebe, Gamarnik, Gesteland, Giegé, Ikeda, Ito, Ito, Jubin, Klinck, Kuiken, Lee, Lindenbach, Liu, Lohmann, Lohmann, Lohmann, Madeleine Struthers, Markham, Matsuda, Matsuda, McMullan, Murayama, Pang, Peter Simmonds, Pietschmann, Romero-López, Romero-López, Schmitt, Simmonds, Song, Tuplin, Tuplin, Tuplin, Wakita, Wang, Wang, Wasley, Wilkinson, Yang, Yi, You, You, Zhao, Zhong, Zuker   +56 more
core   +4 more sources

Cardiotoxicity Assessment of EGFR Tyrosine Kinase Inhibitors Using Human iPS Cell‐Derived Cardiomyocytes and FDA Adverse Events Reporting System

Clinical and Translational Science, Volume 18, Issue 8, August 2025.
ABSTRACT Recent advances in the development of anti‐cancer drugs have contributed to prolonged survival of cancer patients. In contrast, drug‐induced cardiotoxicity, particularly cardiac contractile dysfunction, is of growing concern in cancer treatment.
Shota Yanagida, Hiroyuki Kawagishi, Mitsuo Saito, Hirofumi Hamano, Yoshito Zamami, Yasunari Kanda   +5 more
wiley   +1 more source

Similar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencing.

PLoS ONE, 2014
Background and objectivesHepatitis C virus (HCV) variants that confer resistance to direct-acting-antiviral agents (DAA) have been detected by standard sequencing technology in genotype (G) 1 viruses from DAA-naive patients.
Severine Margeridon-Thermet, Sophie Le Pogam, Lewyn Li, Tommy F Liu, Nancy Shulman, Robert W Shafer, Isabel Najera   +6 more
doaj   +1 more source

Antiviral therapy: Inhibition of Hepatitis C Virus expression by RNA interference directed against the NS5B region of the Viral Genome

Annals of Hepatology, 2007
Background: Hepatitis C virus (HCV) is a major public health problem with 170 million chronically infected people throughout the world. Currently, the only treatment available consists of a combination of pegylated interferon (INF-a) and ribavirin, but ...
Laura Trejo-Ávila;, Regina Elizondo-González;, Karina del C. Trujillo-Murillo;, Pablo Zapata-Benavides;, Cristina Rodríguez-Padilla;, Ana María Rivas-Estilla   +5 more
doaj   +1 more source

Complete genome of a European hepatitis C virus subtype 1g isolate: phylogenetic and genetic analyses [PDF]

, 2008
Background Hepatitis C virus isolates have been classified into six main genotypes and a variable number of subtypes within each genotype, mainly based on phylogenetic analysis.
Bargalló Ana, Martró Elisa, Saludes Verónica, Bracho Maria A, González-Candelas Fernando, Ausina Vicent   +5 more
core   +2 more sources

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, Volume 8, Issue 7, July 2025.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

Annexin, a Protein for All Seasons: From Calcium Dependent Membrane Metabolism to RNA Recognition

BioEssays, Volume 47, Issue 7, July 2025.
Annexins are an important protein family traditionally well known to bind to phospholipids and to interact with various proteins in a calcium dependent way. More recently, it has been established that a feature common to the family is also to bind to RNA having a role in translation. In bies70019 article, Vedeler et al.
Anni Vedeler, Gian Gaetano Tartaglia, Annalisa Pastore   +2 more
wiley   +1 more source

Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study [PDF]

, 2011
Background HIV and HCV infections have become the leading global public-health threats. Even more remarkable, HIV-HCV co-infection is rapidly emerging as a major cause of morbidity and mortality throughout the world, due to the common rapid ...
Qi Liu, Han Zhou, Lin Liu, Xi Chen, Ruixin Zhu, Zhiwei Cao   +5 more
core   +2 more sources

Characterisation of interaction between NS3 and NS5B protein of classical swine fever virus by deletion of terminal sequences of NS5B

Virus Research, 2011
The NS3-NS5B interaction of classical swine fever virus (CSFV) is important for viral replication. For characterisation of the interaction between the NS3 and NS5B, a series of NS5B mutants with deletion of N-, C-terminal amino acids and quadruple alanine substitution mutations were produced. GST pull-down assays and immunoprecipitation analyses showed
Yujing, Wang, Zailing, Zhu, Ping, Wang, Jialin, Yu, Lingzhu, Wan, Jun, Chen, Ming, Xiao   +6 more
openaire   +2 more sources

Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants

Clinical Pharmacology in Drug Development, Volume 14, Issue 6, Page 461-471, June 2025.
Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Janet Hammond   +7 more
wiley   +1 more source