Results 11 to 20 of about 25,630 (256)

Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine releaseResearch in context

EBioMedicine, 2019
Background: Treatment multiple tumors by immune therapy can be achieved by mobilizing both innate and adaptive immunity. The programmed death ligand 1 (PD-L1; or CD274, B7-H1) is a critical “don't find me” signal to the adaptive immune system.
Shu Lian, Ruizhi Xie, Yuying Ye, Xiaodong Xie, Shuhui Li, Yusheng Lu, Bifei Li, Yunlong Cheng, Vladimir L. Katanaev, Lee Jia   +9 more
doaj   +1 more source

NIR-II fluorescence-guided liver cancer surgery by a small molecular HDAC6 targeting probeResearch in context

EBioMedicine, 2023
Summary: Background: Hepatocellular carcinoma (HCC) is the sixth most common malignancy globally and ranks third in terms of both mortality and incidence rates. Surgical resection holds potential as a curative approach for HCC.
Bo Wang, Chu Tang, En Lin, Xiaohua Jia, Ganyuan Xie, Peiping Li, Decheng Li, Qiyue Yang, Xiaoyong Guo, Caiguang Cao, Xiaojing Shi, Baojia Zou, Chaonong Cai, Jie Tian, Zhenhua Hu, Jian Li   +15 more
doaj   +1 more source

Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone

Neural Regeneration Research, 2015
Resistance mechanisms of rho-associated kinase (ROCK) inhibitors are associated with the enhanced expression of cyclooxygenase-2 (COX-2). The therapeutic effects of ROCK on nervous system diseases might be enhanced by COX-2 inhibitors.
Xiao-lin Hou, Yan Chen, Hua Yin, Wei-gang Duan   +3 more
doaj   +1 more source

Femoral nerve regeneration and its accuracy under different injury mechanisms

Neural Regeneration Research, 2015
Surgical accuracy has greatly improved with the advent of microsurgical techniques. However, complete functional recovery after peripheral nerve injury has not been achieved to date.
Aikeremujiang·Muheremu, Qiang Ao, Yu Wang, Peng Cao, Jiang Peng   +4 more
doaj   +1 more source

Bone marrow mesenchymal stem cells transplantation promotes the release of endogenous erythropoietin after ischemic stroke

Neural Regeneration Research, 2015
This study investigated whether bone marrow mesenchymal stem cell (BMSC) transplantation protected ischemic cerebral injury by stimulating endogenous erythropoietin.
Wen Lv, Wen-yu Li, Xiao-yan Xu, Hong Jiang, Oh Yong Bang   +4 more
doaj   +1 more source

Electroacupuncture preconditioning attenuates ischemic brain injury by activation of the adenosine monophosphate-activated protein kinase signaling pathway

Neural Regeneration Research, 2015
Electroacupuncture has therapeutic effects on ischemic brain injury, but its mechanism is still poorly understood. In this study, mice were stimulated by electroacupuncture at the Baihui (GV20) acupoint for 30 minutes at 1 mA and 2/15 Hz for 5 ...
Qiang-qiang Ran, Huai-long Chen, Yan-li Liu, Hai-xia Yu, Fei Shi, Ming-shan Wang   +5 more
doaj   +1 more source

Neuroprotective effect of Shenqi Fuzheng injection pretreatment in aged rats with cerebral ischemia/reperfusion injury

Neural Regeneration Research, 2016
Shenqi Fuzheng injection is extracted from the Chinese herbs Radix Astragali and Radix Codonopsis. The aim of the present study was to investigate the neuroprotective effects of Shenqi Fuzheng injection in cerebral ischemia and reperfusion. Aged rats (20-
Ying-min Cai, Yong Zhang, Peng-bo Zhang, Lu-ming Zhen, Xiao-ju Sun, Zhi-ling Wang, Ren-yan Xu, Rong-liang Xue   +7 more
doaj   +1 more source

Environmental ciprofloxacin triggers pregnancy loss: senescence-driven miscarriage via TRIM21-mediated MFF degradationResearch in context

EBioMedicine
Summary: Background: Antibiotic abuse has become a top public health problem worldwide. Ciprofloxacin (CIP) has the highest detection rate in human but its association with unexplained miscarriage (UM) is completely unknown.
Yi Sun (孙义), Yanbing Lin (林晏冰), Shuaishuai Xing (幸帅帅), Wenxin Huang (黄文欣), Yanxin Wang, Geng Guo, Haijun Yan, Depeng Zhao, Wenli Cheng, Zhengzhong Wu, Chenghui Huang, Zhihong Zhang, Linlin Wu (吴琳琳), Qingzhi Hou (侯青芝), Huidong Zhang (张慧东)   +14 more
doaj   +1 more source

Axon regeneration impediment: the role of paired immunoglobulin-like receptor B

Neural Regeneration Research, 2015
Regenerative capacity is weak after central nervous system injury because of the absence of an enhancing microenvironment and presence of an inhibitory microenvironment for neuronal and axonal repair.
Jing Liu, Yan Wang, Wei Fu
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source