Results 41 to 50 of about 62,880 (273)

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects

Neural Regeneration Research, 2015
Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. We presumed that amentoflavone exerts a neuroprotective effect in epilepsy models.
Zhen Zhang, Tao Sun, Jian-guo Niu, Zhen-quan He, Yang Liu, Feng Wang   +5 more
doaj   +1 more source

Characteristics, Diagnosis and Prognosis of Acute-on-Chronic Liver Failure in Cirrhosis Associated to Hepatitis B [PDF]

, 2016
The study was supported by National Natural Science Foundation of China (NSFC), grant number: 30770962, 30971333, 81170421, 81470869 and Chinese High Technology “863” programme, grant number: 2006AA02A411 (Hai.Li); The CLIF Consortium Data Management ...
Amoros, A, Arroyo, V, Chen, L-Y, Dusheiko, G, Foster, GR, Gines, P, Hua, J, Jalan, R, Li, H, Li, S-T, Ma, X, Mookerjee, RP, Moreau, R, Pavesi, M, Qiu, D-K, Sheng, L, Xia, Q, Xie, Q, Xue, F, Zeng, B, Zhang, N-N   +20 more
core   +2 more sources

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Comprehensive systematic review and meta-analysis of risk factors for childhood obesity in China and future intervention strategiesResearch in context

The Lancet Regional Health. Western Pacific
Summary: Background: Childhood obesity is a critical public health concern in China. This study identified the key determinants of childhood obesity in China and provided recommendations for future intervention strategies.
Yanfen Jiang, Jiajin Hu, Fengyan Chen, Borui Liu, Mengna Wei, Wenqi Xia, Yinkun Yan, Jinchen Xie, Shufa Du, Xiangyang Tian, Izzuddin M. Aris, Youfa Wang, Jianduan Zhang   +12 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Development of an MRI based artificial intelligence model for the identification of underlying atrial fibrillation after ischemic stroke: a multicenter proof-of-concept analysisResearch in context

EClinicalMedicine
Summary: Background: Atrial fibrillation (AF) represents a major risk factor of ischemic stroke recurrence with serious management implications. However, it often remains undiagnosed due to lack of standard or prolonged cardiac rhythm monitoring. We aim
Zijie Zhang, Yang Ding, Kaibin Lin, Wenli Ban, Luyue Ding, Yudong Sun, Chuanliang Fu, Yihang Ren, Can Han, Xue Zhang, Xiaoer Wei, Shundong Hu, Yuwu Zhao, Li Cao, Jun Wang, Saman Nazarian, Ying Cao, Lan Zheng, Min Zhang, Jianliang Fu, Jingbo Li, Xiang Han, Dahong Qian, Dong Huang   +23 more
doaj   +1 more source

Universal data-based method for reconstructing complex networks with binary-state dynamics [PDF]

, 2016
ACKNOWLEDGMENTS W.-X.W. was supported by NSFC under Grant No. 61573064, No. 61074116, and No. 71631002, as well as the Fundamental Research Funds for the Central Universities, Beijing Nova Programme. Y.-C.L. was supported by ARO under Grant No. W911NF-14-
Grebogi, Celso, Lai, Ying-Cheng, Li, Jingwen, Shen, Zhesi, Wang, Wen-Xu   +4 more
core   +2 more sources

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

Blockade of transient receptor potential cation channel subfamily V member 1 promotes regeneration after sciatic nerve injury

Neural Regeneration Research, 2015
The transient receptor potential cation channel subfamily V member 1 (TRPV1) provides the sensation of pain (nociception). However, it remains unknown whether TRPV1 is activated after peripheral nerve injury, or whether activation of TRPV1 affects neural
Fei Ren, Hong Zhang, Chao Qi, Mei-ling Gao, Hong Wang, Xia-qing Li   +5 more
doaj   +1 more source